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Schoone GJ, Everard CO, Korver H, et al. An immunoprotective monoclonal antibody directed against Leptospira interrogans serovar copenhageni. J Gen Microbiol. 1989;135(1):73-8doi: 10.1099/00221287-135-1-73.
Schoone, G. J., Everard, C. O., Korver, H., Carrington, D. G., Inniss, V. A., Baulu, J., & Terpstra, W. J. (1989). An immunoprotective monoclonal antibody directed against Leptospira interrogans serovar copenhageni. Journal of general microbiology, 135(1), 73-8. https://doi.org/10.1099/00221287-135-1-73
Schoone, G J, et al. "An immunoprotective monoclonal antibody directed against Leptospira interrogans serovar copenhageni." Journal of general microbiology vol. 135,1 (1989): 73-8. doi: https://doi.org/10.1099/00221287-135-1-73
Schoone GJ, Everard CO, Korver H, Carrington DG, Inniss VA, Baulu J, Terpstra WJ. An immunoprotective monoclonal antibody directed against Leptospira interrogans serovar copenhageni. J Gen Microbiol. 1989 Jan;135(1):73-8. doi: 10.1099/00221287-135-1-73. PMID: 2778433.
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J Gen Microbiol. 1989 Jan;135(1):73-8. doi: 10.1099/00221287-135-1-73.

An immunoprotective monoclonal antibody directed against Leptospira interrogans serovar copenhageni.

Journal of general microbiology

G J Schoone, C O Everard, H Korver, D G Carrington, V A Inniss, J Baulu, W J Terpstra

Affiliations

  1. N. H. Swellengrebel Laboratory of Tropical Hygiene, Royal Tropical Institute, Amsterdam, The Netherlands.

PMID: 2778433 DOI: 10.1099/00221287-135-1-73

Abstract

A monoclonal antibody (mAb) was prepared by hybridoma technology in BALB/c mice immunized to Leptospira interrogans serovar copenhageni. This mAb agglutinated serovars copenhageni and icterohaemorrhagiae to high titres and protected hamsters, dogs and monkeys against challenge with a virulent strain of serovar copenhageni. The mAb gave protection to hamsters at dilutions up to 1 in 1000; at a 1 in 10 dilution the protective effect lasted for at least two weeks. Biochemical analysis by SDS-PAGE and Western blotting indicated that this mAb reacted with an epitope of a carbohydrate nature.

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