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Young ML, Tan RC, Ramza BM, et al. Effects of hypoxia on atrioventricular node of adult and neonatal rabbit hearts. Am J Physiol. 1989;256(5):H1337-43doi: 10.1152/ajpheart.1989.256.5.H1337.
Young, M. L., Tan, R. C., Ramza, B. M., & Joyner, R. W. (1989). Effects of hypoxia on atrioventricular node of adult and neonatal rabbit hearts. The American journal of physiology, 256(5), H1337-43. https://doi.org/10.1152/ajpheart.1989.256.5.H1337
Young, M L, et al. "Effects of hypoxia on atrioventricular node of adult and neonatal rabbit hearts." The American journal of physiology vol. 256,5 (1989): H1337-43. doi: https://doi.org/10.1152/ajpheart.1989.256.5.H1337
Young ML, Tan RC, Ramza BM, Joyner RW. Effects of hypoxia on atrioventricular node of adult and neonatal rabbit hearts. Am J Physiol. 1989 May;256(5):H1337-43. doi: 10.1152/ajpheart.1989.256.5.H1337. PMID: 2719132.
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Am J Physiol. 1989 May;256(5):H1337-43. doi: 10.1152/ajpheart.1989.256.5.H1337.

Effects of hypoxia on atrioventricular node of adult and neonatal rabbit hearts.

The American journal of physiology

M L Young, R C Tan, B M Ramza, R W Joyner

Affiliations

  1. Department of Pediatrics, University of Iowa Hospital and Clinics, Iowa City.

PMID: 2719132 DOI: 10.1152/ajpheart.1989.256.5.H1337

Abstract

We used an isolated perfused heart model to assess the effects of graded hypoxia (95, 45, 20, 10, or 0% O2, exposure for 5 min) on the adult and neonatal (0-3 days) rabbit atrioventricular (AV) node. The AV nodal function was assessed by measuring the A-H interval at a constant atrial pacing cycle length, the longest pacing cycle length resulting in Wenckebach periodicity [Wenckebach cycle length (WCL)] and the AV nodal effective refractory period (AVNERP). The A-H intervals remained stable in neonatal hearts until O2 saturation was decreased to 10%. On the other hand, the A-H intervals began to increase in adult rabbit hearts at 20% O2. In 95% O2, the AV nodal WCL was longer in adult hearts than in the neonatal hearts (165 +/- 8 ms vs. 142 +/- 7 ms). The effect of hypoxia on the AV nodal WCL was significantly greater in adult hearts than in neonatal hearts when the O2 saturation was decreased to 20% (a 54% increase in adults vs. a 14% increase in neonates, P = 0.02). The difference was greater at lower levels of O2. In 95% O2 at comparable basis driving cycle length (240 ms), the A-H intervals were equal in neonatal and adult hearts (43 +/- 3 vs. 43 +/- 7 ms), but the AVNERP of the neonates was significantly longer than that of the adults (133 +/- 21 vs. 97 +/- 19 ms, P = 0.007).(ABSTRACT TRUNCATED AT 250 WORDS)

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