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Hubel KA, Renquist KS, Varley G. Noradrenergic influence on epithelial responses of rabbit ileum to secretagogues. Am J Physiol. 1989;256(5):G919-24doi: 10.1152/ajpgi.1989.256.5.G919.
Hubel, K. A., Renquist, K. S., & Varley, G. (1989). Noradrenergic influence on epithelial responses of rabbit ileum to secretagogues. The American journal of physiology, 256(5), G919-24. https://doi.org/10.1152/ajpgi.1989.256.5.G919
Hubel, K A, et al. "Noradrenergic influence on epithelial responses of rabbit ileum to secretagogues." The American journal of physiology vol. 256,5 (1989): G919-24. doi: https://doi.org/10.1152/ajpgi.1989.256.5.G919
Hubel KA, Renquist KS, Varley G. Noradrenergic influence on epithelial responses of rabbit ileum to secretagogues. Am J Physiol. 1989 May;256(5):G919-24. doi: 10.1152/ajpgi.1989.256.5.G919. PMID: 2719113.
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Am J Physiol. 1989 May;256(5):G919-24. doi: 10.1152/ajpgi.1989.256.5.G919.

Noradrenergic influence on epithelial responses of rabbit ileum to secretagogues.

The American journal of physiology

K A Hubel, K S Renquist, G Varley

Affiliations

  1. Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242.

PMID: 2719113 DOI: 10.1152/ajpgi.1989.256.5.G919

Abstract

Norepinephrine is one of three neurotransmitters that may act directly on enterocytes to enhance absorption; its interaction with secretagogues is of physiological importance. We have studied the influence of norepinephrine on the short-circuit current (Isc) responses to acetylcholine (ACh; 10 microM), vasoactive intestinal polypeptide (VIP; 100 pM-10 nM), peptide histidine isoleucine (PHI; 100 pM-10 nM), histamine (0.1 mM), and to electrical field stimulation (EFS) of rabbit ileum mounted in flux chambers. Tetrodotoxin reduced the response to norepinephrine (10 microM) by 40% and to histamine by 32% but did not affect responses to VIP or PHI. Norepinephrine decreased the ACh response (EC50, 70 nM) and reduced the responses to PHI (less than or equal to 87%), to EFS (less than or equal to 75%), and to histamine (less than or equal to 42%). Norepinephrine decreased the response to VIP (500 pM) but not to higher or lower VIP concentrations. It enhanced the response to VIP (10 nM) and to theophylline (5 mM). We conclude that 1) norepinephrine increases absorption by acting on nerves and enterocytes; 2) the failure of norepinephrine to reduce the Isc response to VIP when the VIP-induced increment in Isc is comparable to that caused by EFS is evidence that VIP does not mediate the EFS response; 3) PHI might mediate the EFS response; and 4) VIP, PHI, and histamine affect enterocytes directly; histamine also affects intrinsic nerves.

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