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Chang JY, Owman C. Serotonin potentiates noradrenaline-induced vasoconstriction through 5-HT1-type receptors in guinea pig basilar artery. J Cereb Blood Flow Metab. 1989;9(5):713-6doi: 10.1038/jcbfm.1989.100.
Chang, J. Y., & Owman, C. (1989). Serotonin potentiates noradrenaline-induced vasoconstriction through 5-HT1-type receptors in guinea pig basilar artery. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 9(5), 713-6. https://doi.org/10.1038/jcbfm.1989.100
Chang, J Y, and Owman, C. "Serotonin potentiates noradrenaline-induced vasoconstriction through 5-HT1-type receptors in guinea pig basilar artery." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism vol. 9,5 (1989): 713-6. doi: https://doi.org/10.1038/jcbfm.1989.100
Chang JY, Owman C. Serotonin potentiates noradrenaline-induced vasoconstriction through 5-HT1-type receptors in guinea pig basilar artery. J Cereb Blood Flow Metab. 1989 Oct;9(5):713-6. doi: 10.1038/jcbfm.1989.100. PMID: 2777937.
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J Cereb Blood Flow Metab. 1989 Oct;9(5):713-6. doi: 10.1038/jcbfm.1989.100.

Serotonin potentiates noradrenaline-induced vasoconstriction through 5-HT1-type receptors in guinea pig basilar artery.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

J Y Chang, C Owman

Affiliations

  1. Department of Medical Cell Research, University of Lund, Sweden.

PMID: 2777937 DOI: 10.1038/jcbfm.1989.100

Abstract

Based on the previous finding that 5-hydroxytryptamine (5-HT) co-exists with norepinephrine (NE) in cerebrovascular sympathetic nerve fibers and can be released during electrical nerve stimulation, the postjunctional interaction between the two amines was studied in isolated basilar artery of guinea pig. A low concentration of 5-HT, which in itself has little or no constrictive effect, potentiated the weak contraction of NE by almost 300%. The amplification was antagonized by methiothepin, but not by ketanserin, and it could be mimicked by methysergide. The marked potentiation is thus probably associated with the 5-HT1-like receptors, which earlier have been found to mediate the direct vasoconstrictive action of 5-HT in this vessel preparation.

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