Display options
Cite
Arrowood JA, Mohanty PK, Hodgson JM, et al. Ventricular sensory endings mediate reflex bradycardia during coronary arteriography in humans. Circulation. 1989;80(5):1293-300doi: 10.1161/01.cir.80.5.1293.
Arrowood, J. A., Mohanty, P. K., Hodgson, J. M., Dibner-Dunlap, M. E., & Thames, M. D. (1989). Ventricular sensory endings mediate reflex bradycardia during coronary arteriography in humans. Circulation, 80(5), 1293-300. https://doi.org/10.1161/01.cir.80.5.1293
Arrowood, J A, et al. "Ventricular sensory endings mediate reflex bradycardia during coronary arteriography in humans." Circulation vol. 80,5 (1989): 1293-300. doi: https://doi.org/10.1161/01.cir.80.5.1293
Arrowood JA, Mohanty PK, Hodgson JM, Dibner-Dunlap ME, Thames MD. Ventricular sensory endings mediate reflex bradycardia during coronary arteriography in humans. Circulation. 1989 Nov;80(5):1293-300. doi: 10.1161/01.cir.80.5.1293. PMID: 2805265.
Copy Download .nbib Format: NLM
Share it on
Full text links
Atypon

Circulation. 1989 Nov;80(5):1293-300. doi: 10.1161/01.cir.80.5.1293.

Ventricular sensory endings mediate reflex bradycardia during coronary arteriography in humans.

Circulation

J A Arrowood, P K Mohanty, J M Hodgson, M E Dibner-Dunlap, M D Thames

Affiliations

  1. Department of Internal Medicine (Cardiology), Medical College of Virginia, Richmond 23298.

PMID: 2805265 DOI: 10.1161/01.cir.80.5.1293

Abstract

It has been suggested that the response to the intracoronary injection of radiographic contrast is reflex in origin and results from stimulation of ventricular sensory endings. Cardiac transplantation results in denervation of the ventricles, and thus, may interrupt the afferent limb of this reflex. In contrast, the recipient sinus node and atrial remnant remain innervated, leaving the efferent cardiac limb of this reflex intact. We hypothesized that if contrast-induced reflex bradycardia and hypotension occurred from stimulation of ventricular chemosensitive endings, then this response would be abolished after cardiac transplantation. To test this hypothesis, we determined the changes in recipient (innervated) and donor (denervated) sinus-node rates (SNR) and mean arterial pressure during selective right (RCA) and left coronary artery (LCA) injection during arteriography in cardiac transplant patients and in patients with intact cardiac innervation. An increase in the recipient SNR was observed in cardiac transplant patients during left and right coronary injections (LCA, 6.6 +/- 1.7 beats/min; RCA, 2.4 +/- 1.4 beats/min) compared with a decrease in the control subjects (LCA, -15.3 +/- 2.3 beats/min; RCA, -6.9 +/- 1.9 beats/min; p less than 0.05 vs. control). This occurred despite significant and comparable decreases in mean arterial pressure in cardiac transplant patients (LCA, -12.7 +/- 2.3 mm Hg; RCA, -11.4 +/- 2.2 mm Hg) and control subjects (LCA, -18.7 +/- 1.7 mm Hg; RCA, -10.7 +/- 1.6 mm Hg). The donor SNR slowed for LCA injection (-5.4 +/- 2.1 beats/min, p less than 0.05) and RCA injection (-3.0 +/- 1.7 beats/min), which, for the LCA, was less than the slowing of control subjects (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

Similar articles

Substances

MeSH terms

Publication Types

Grant support

LinkOut - more resources