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Garrett LR, Chung JG, Byers PE, et al. Dietary effects of pristane on rat lymphoid tissues. Agents Actions. 1989;28(3):272-8doi: 10.1007/BF01967414.
Garrett, L. R., Chung, J. G., Byers, P. E., & Cuchens, M. A. (1989). Dietary effects of pristane on rat lymphoid tissues. Agents and actions, 28(3), 272-8. https://doi.org/10.1007/BF01967414
Garrett, L R, et al. "Dietary effects of pristane on rat lymphoid tissues." Agents and actions vol. 28,3 (1989): 272-8. doi: https://doi.org/10.1007/BF01967414
Garrett LR, Chung JG, Byers PE, Cuchens MA. Dietary effects of pristane on rat lymphoid tissues. Agents Actions. 1989 Nov;28(3):272-8. doi: 10.1007/BF01967414. PMID: 2596378.
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Agents Actions. 1989 Nov;28(3):272-8. doi: 10.1007/BF01967414.

Dietary effects of pristane on rat lymphoid tissues.

Agents and actions

L R Garrett, J G Chung, P E Byers, M A Cuchens

Affiliations

  1. Department of Microbiology, University of Mississippi Medical Center, Jackson 39216-4505.

PMID: 2596378 DOI: 10.1007/BF01967414

Abstract

Studies were conducted to assess the normal tissue-associated levels of pristane (2,6,10,14,-tetramethylpentadecane) in Copenhagen rats during ontogeny and adult life and to address whether or not dietary pristane can be adsorbed from the gut and disseminated throughout the body. During the course of this study the possible effects of dietary pristane on chromatin conformation of lymphoid cells were also examined by flow cytometry. The data indicated that 1) pristane crossed the placenta and accumulated in fetal tissues, 2) neonates were exposed to pristane via the colostrum, 3) there were significant increases in the amount of tissue-associated pristane in young adults and subsequent redistribution of the pristane to the muscle and adipose tissues in older rats and 4) after dietary exposure, significantly elevated levels of pristane were associated with the tissues and concomitant changes in chromatin conformation were observed. Collectively, these results suggest that pristane was adsorbed from dietary sources, disseminated to the tissues and exerted a transient, yet marked effect on chromatin of lymphoid cells in rats.

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