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Elsevier Science

Gastroenterology. 1989 Oct;97(4):1019-21. doi: 10.1016/0016-5085(89)91512-6.

Membranous obstruction of the inferior vena cava associated with a myeloproliferative disorder: a clue to membrane formation?.

Gastroenterology

F Sevenet, H Deramond, A Hadengue, N Casadevall, J Delamarre, J P Capron

Affiliations

  1. Services d'Hépato-gastroentérologie et de Radiologie A, CHU Nord, Amiens, France.

PMID: 2777025 DOI: 10.1016/0016-5085(89)91512-6

Abstract

Although membranous obstruction of the inferior vena cava is frequently assumed to be a congenital defect, it has recently been hypothesized that it could be acquired and secondary to thrombosis at the ostium of hepatic veins. We report the case of a membranous obstruction of the inferior vena cava responsible for isolated hepatomegaly in a young Frenchman. No known cause of thrombosis was found but spontaneous formation of erythroid colonies occurred on bone marrow cultures. This indicated the existence of a latent myeloproliferative disorder, a frequent cause of hepatic vein thrombosis. We suggest that this association of a membranous obstruction of the inferior vena cava with a known, albeit often overlooked, cause of hepatic vein thrombosis provides strong support to the thrombosis theory of membrane formation.

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