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Wiley Free PMC Article

Br J Clin Pharmacol. 1989 Aug;28(2):202-4. doi: 10.1111/j.1365-2125.1989.tb05418.x.

Pharmacokinetics of intravenous buprenorphine in children.

British journal of clinical pharmacology

K T Olkkola, E L Maunuksela, R Korpela

Affiliations

  1. Department of Clinical Pharmacology, University of Helsinki, Finland.

PMID: 2775626 PMCID: PMC1379907 DOI: 10.1111/j.1365-2125.1989.tb05418.x
Free PMC Article

Abstract

Buprenorphine (3 micrograms kg-1) was given intravenously as premedication to small children (age 4-7 years) undergoing minor surgery. Because of the rapid decline of the plasma buprenorphine concentrations, the terminal elimination half-life could not be estimated reliably. Given this constraint, values of clearance appeared to be higher than those in adults but values of Vss were similar.

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