Circ Res. 1975 May;36(5):599-609. doi: 10.1161/01.res.36.5.599.

Modulation by prostaglandins of adrenergic transmission in the isolated perfused rabbit and rat kidney.

Circulation research

K U Malik, J C McGiff

PMID: 235374 DOI: 10.1161/01.res.36.5.599

Abstract

In the isolated perfused rabbit kidney prostaglandins (PGS) E1 (0.02-0-1 ng/ml), E2 (0.02-0.1 ng/ml), and A2 (1-5 ng/ml) inhibited the vasoconstrictor responses to sympathetic nerve stimulation by 21-44%, 31-39%, and 20-23%, respectively, without alerting those to injected norepinephrine. In contrast, in the rat kidney PGE1 (0.5 ng/ml), PGE2 (0.5 ng/ml), and PGA2 (5 ng/ml) enhanced the vasoconstrictor responses to sympathetic nerve stimulation by 41%, 27%, and 11%, respectively; the equiconstrictor responses to injected norepinephrine remained unaltered. Higher concentrations of these agents produced vasodilation in the rabbit kidney and vasoconstriction in the rat kidney. In both species PGF2alpha produced vasoconstriction and enhanced the response to both adrenergic stumuli. In the rabbit kidney inhibitors of PG synthesis augmented the responses to sympathetic nerve stimulation without altering those to injected norepinephrine, whereas in the rat kidney inhibition of the responses to both adrenergic stimuli occurred. Arachidonic acid inhibited the vasoconstrictor responses to sympathetic nerve stimulation in the rabbit kidney, but in the rat kidney it caused augmentation of these responses. Since these effects of arachidonic acid were reduced by indomethacin, they appear to be mediated through the acid's conversion to PGS. We conclude that PGS of the E series modulate adrenergic transmission in the kidney and that their modulatory actions are species dependent.

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Substances

• Arachidonic Acids
• Neurotransmitter Agents
• Prostaglandins
• Prostaglandins A
• Prostaglandins E
• Meclofenamic Acid
• Norepinephrine
• Indomethacin

MeSH terms

• Animals
• Arachidonic Acids / pharmacology
• Electric Stimulation
• Female
• Indomethacin / pharmacology
• Kidney / drug effects
• Kidney / innervation
• Male
• Meclofenamic Acid / pharmacology
• Neurotransmitter Agents
• Norepinephrine / pharmacology
• Prostaglandins / biosynthesis
• Prostaglandins / pharmacology
• Prostaglandins A / pharmacology
• Prostaglandins E / pharmacology
• Rabbits
• Synaptic Transmission / drug effects
• Vasomotor System / drug effects

Publication Types

• Journal Article
• Research Support, U.S. Gov't, P.H.S.

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