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Jung IY, Kim JJ, Lee SJ, et al. Antibiotic-Related Adverse Drug Reactions at a Tertiary Care Hospital in South Korea. Biomed Res Int. 2017;2017:4304973doi: 10.1155/2017/4304973.
Jung, I. Y., Kim, J. J., Lee, S. J., Kim, J., Seong, H., Jeong, W., Choi, H., Jeong, S. J., Ku, N. S., Han, S. H., Choi, J. Y., Song, Y. G., Park, J. W., & Kim, J. M. (2017). Antibiotic-Related Adverse Drug Reactions at a Tertiary Care Hospital in South Korea. BioMed research international, 20174304973. https://doi.org/10.1155/2017/4304973
Jung, In Young, et al. "Antibiotic-Related Adverse Drug Reactions at a Tertiary Care Hospital in South Korea." BioMed research international vol. 2017 (2017): 4304973. doi: https://doi.org/10.1155/2017/4304973
Jung IY, Kim JJ, Lee SJ, Kim J, Seong H, Jeong W, Choi H, Jeong SJ, Ku NS, Han SH, Choi JY, Song YG, Park JW, Kim JM. Antibiotic-Related Adverse Drug Reactions at a Tertiary Care Hospital in South Korea. Biomed Res Int. 2017;2017:4304973. doi: 10.1155/2017/4304973. Epub 2017 Dec 31. PMID: 29457026; PMCID: PMC5804292.
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Biomed Res Int. 2017;2017:4304973. doi: 10.1155/2017/4304973. Epub 2017 Dec 31.

Antibiotic-Related Adverse Drug Reactions at a Tertiary Care Hospital in South Korea.

BioMed research international

In Young Jung, Jung Ju Kim, Se Ju Lee, Jinnam Kim, Hye Seong, Wooyong Jeong, Heun Choi, Su Jin Jeong, Nam Su Ku, Sang Hoon Han, Jun Yong Choi, Young Goo Song, Jung Won Park, June Myung Kim

Affiliations

  1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
  2. AIDS Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
  3. Institute of Allergy, Yonsei University College of Medicine, Seoul, Republic of Korea.

PMID: 29457026 PMCID: PMC5804292 DOI: 10.1155/2017/4304973

Abstract

BACKGROUND: Adverse drug reactions (ADRs) are any unwanted/uncomfortable effects from medication resulting in physical, mental, and functional injuries. Antibiotics account for up to 40.9% of ADRs and are associated with several serious outcomes. However, few reports on ADRs have evaluated only antimicrobial agents. In this study, we investigated antibiotic-related ADRs at a tertiary care hospital in South Korea.

METHODS: This is a retrospective cohort study that evaluated ADRs to antibiotics that were reported at a 2400-bed tertiary care hospital in 2015. ADRs reported by physicians, pharmacists, and nurses were reviewed. Clinical information reported ADRs, type of antibiotic, causality assessment, and complications were evaluated.

RESULTS: 1,277 (62.8%) patients were considered antibiotic-related ADRs based on the World Health Organization-Uppsala Monitoring Center criteria (certain, 2.2%; probable, 35.7%; and possible, 62.1%). Totally, 44 (3.4%) patients experienced serious ADRs. Penicillin and quinolones were the most common drugs reported to induce ADRs (both 16.0%), followed by third-generation cephalosporins (14.9%). The most frequently experienced side effects were skin manifestations (45.1%) followed by gastrointestinal disorders (32.6%).

CONCLUSION: Penicillin and quinolones are the most common causative antibiotics for ADRs and skin manifestations were the most frequently experienced symptom.

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