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Duong N, Lee A, Lewis J. Case of acute mixed liver injury due to hypothyroidism. BMJ Case Rep. 2018;2018doi: 10.1136/bcr-2017-222373.
Duong, N., Lee, A., & Lewis, J. (2018). Case of acute mixed liver injury due to hypothyroidism. BMJ case reports, 2018. https://doi.org/10.1136/bcr-2017-222373
Duong, Nikki, et al. "Case of acute mixed liver injury due to hypothyroidism." BMJ case reports vol. 2018 (2018). doi: https://doi.org/10.1136/bcr-2017-222373
Duong N, Lee A, Lewis J. Case of acute mixed liver injury due to hypothyroidism. BMJ Case Rep. 2018 Jan 23;2018. doi: 10.1136/bcr-2017-222373. PMID: 29367365; PMCID: PMC5786968.
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BMJ Case Rep. 2018 Jan 23;2018. doi: 10.1136/bcr-2017-222373.

Case of acute mixed liver injury due to hypothyroidism.

BMJ case reports

Nikki Duong, Alice Lee, James Lewis

Affiliations

  1. Department of Internal Medicine, MedStar Georgetown University Hospital, Washington, DC, USA.

PMID: 29367365 PMCID: PMC5786968 DOI: 10.1136/bcr-2017-222373

Abstract

The effects of hypothyroidism on the liver are not well understood. A 77-year-old woman with Hashimoto's thyroiditis had stopped taking levothyroxine on her own for 6 months. Her thyroid stimulating hormone (TSH) level was consistent with severe hypothyroidism. She resumed thyroid replacement therapy. The following month, her liver function tests were significantly elevated. Seven weeks after resumption of therapy, her TSH and liver tests had returned to normal. We attribute the mixed hepatocellular injury to hypothyroidism that resolved on correction of the hypothyroid state. This case reminds us that thyroid disease should be considered when evaluating acute liver injury.

© BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Keywords: general practice / family medicine; hepatitis other

Conflict of interest statement

Competing interests: None declared.

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