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Bersten A, Sibbald WJ. Circulatory disturbances in multiple systems organ failure. Crit Care Clin. 1989;5(2):233-54
Bersten, A., & Sibbald, W. J. (1989). Circulatory disturbances in multiple systems organ failure. Critical care clinics, 5(2), 233-54.
Bersten, A, and Sibbald, W J. "Circulatory disturbances in multiple systems organ failure." Critical care clinics vol. 5,2 (1989): 233-54.
Bersten A, Sibbald WJ. Circulatory disturbances in multiple systems organ failure. Crit Care Clin. 1989 Apr;5(2):233-54. PMID: 2650816.
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Crit Care Clin. 1989 Apr;5(2):233-54.

Circulatory disturbances in multiple systems organ failure.

Critical care clinics

A Bersten, W J Sibbald

Affiliations

  1. Richard Ivey Critical Care Trauma Centre, Victoria Hospital, London, Canada.

PMID: 2650816

Abstract

Circulatory disturbances in MSOF disturb normal metabolic autoregulation, the ability to continuously couple tissue oxygen delivery with oxygen need. These may occur at three levels of the circulation: the heart; the regional circulations; and the microcirculation. This article will summarize evidence demonstrating that MSOF is associated with reduced tissue oxygen delivery by virtue of changes in all three circulatory components governing the inadequacy of metabolic autoregulation in sepsis.

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