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Finger LR, Kagan J, Christopher G, et al. Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. Proc Natl Acad Sci U S A. 1989;86(13):5039-43doi: 10.1073/pnas.86.13.5039.
Finger, L. R., Kagan, J., Christopher, G., Kurtzberg, J., Hershfield, M. S., Nowell, P. C., & Croce, C. M. (1989). Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. Proceedings of the National Academy of Sciences of the United States of America, 86(13), 5039-43. https://doi.org/10.1073/pnas.86.13.5039
Finger, L R, et al. "Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma." Proceedings of the National Academy of Sciences of the United States of America vol. 86,13 (1989): 5039-43. doi: https://doi.org/10.1073/pnas.86.13.5039
Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC, Croce CM. Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. Proc Natl Acad Sci U S A. 1989 Jul;86(13):5039-43. doi: 10.1073/pnas.86.13.5039. PMID: 2740341; PMCID: PMC297552.
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Proc Natl Acad Sci U S A. 1989 Jul;86(13):5039-43. doi: 10.1073/pnas.86.13.5039.

Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma.

Proceedings of the National Academy of Sciences of the United States of America

L R Finger, J Kagan, G Christopher, J Kurtzberg, M S Hershfield, P C Nowell, C M Croce

Affiliations

  1. Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140.

PMID: 2740341 PMCID: PMC297552 DOI: 10.1073/pnas.86.13.5039
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Abstract

We analyzed a t(1;14)(p32;q11) chromosomal translocation in a human lymphohemopoietic stem cell line derived from a patient with acute T-lymphoblastic leukemia. The chromosomal joining on the 1p+ chromosome occurred at the T-cell receptor delta diversity (D delta 2) segment, and the reciprocal chromosomal joining on the 14q- chromosome occurred at the T-cell delta diversity segment D delta 1. The involvement of delta diversity segments at the translocation junctions suggests that the translocation occurred during an attempt at D delta 1-D delta 2 joining in a stem cell. The segment of chromosome 1 at band p32, adjacent to the chromosomal breakpoint, encodes a transcriptional unit designated TCL5 (T-cell leukemia/lymphoma 5). The differential expression of the TCL5 RNA transcripts in this lymphohemopoietic stem cell line relative to several other T- and B-cell lines suggests that TCL5 gene expression is an integral event in the pathogenesis of the T-cell leukemia. Rearrangement of the TCL5 locus in a human melanoma cell line carrying a del(1p32) further implies that the TCL5 gene may play a role in malignant transformation.

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