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Gildersleeve DL, Pearson TA, Baghdiantz A, et al. Effect of ACTH, alpha-MSH, and beta-Lipotropin on calcium and phosphorus metabolism in the rabbit. Endocrinology. 1975;97(6):1593-6doi: 10.1210/endo-97-6-1593.
Gildersleeve, D. L., Pearson, T. A., Baghdiantz, A., & Foster, G. V. (1975). Effect of ACTH, alpha-MSH, and beta-Lipotropin on calcium and phosphorus metabolism in the rabbit. Endocrinology, 97(6), 1593-6. https://doi.org/10.1210/endo-97-6-1593
Gildersleeve, D L, et al. "Effect of ACTH, alpha-MSH, and beta-Lipotropin on calcium and phosphorus metabolism in the rabbit." Endocrinology vol. 97,6 (1975): 1593-6. doi: https://doi.org/10.1210/endo-97-6-1593
Gildersleeve DL, Pearson TA, Baghdiantz A, Foster GV. Effect of ACTH, alpha-MSH, and beta-Lipotropin on calcium and phosphorus metabolism in the rabbit. Endocrinology. 1975 Dec;97(6):1593-6. doi: 10.1210/endo-97-6-1593. PMID: 173530.
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Endocrinology. 1975 Dec;97(6):1593-6. doi: 10.1210/endo-97-6-1593.

Effect of ACTH, alpha-MSH, and beta-Lipotropin on calcium and phosphorus metabolism in the rabbit.

Endocrinology

D L Gildersleeve, T A Pearson, A Baghdiantz, G V Foster

PMID: 173530 DOI: 10.1210/endo-97-6-1593

Abstract

Studies were undertaken to investigate the effects of synthetic 1-24 adrenocorticotropin (ACTH), bovine alpha melanocyte-stimulating hormone (alpha-MSH), and ovine beta lipotropin (beta-LPH) on plasma calcium and phosphate in rabbits. Equimolar concentrations of these hormones were infused intravenously in intact and thyroidectomized animals. In addition, ACTH was similarly administered to adrenalectomized rabbits. ACTH, alpha-MSH, and beta-LPH all lowered plasma calcium and raised plasma phosphate. These changes were not prevented by prior thyroidectomy. ACTH was equally effective in inducing hypocalcemia and hyperphosphatemia in the absence of the adrenal glands, while adrenalectomy alone raised plasma calcium. From these findings we have concluded that 1) ACTH, alpha-MSH, and betaLPH affect phosphate as well as calcium metabolism; 2) these hormones do not act by releasing calcitonin; and 3) ACTH exerts its hypocalcemic-hyperphosphatemic effect, at least in part, independently of its trophic action on the adrenal glands.

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