Display options
Cite
Aksnes G, Ellingsen O, Rutlen DL, et al. Myocardial K+ repletion and rise in contractility after brief ischemic periods in the pig. J Mol Cell Cardiol. 1989;21(7):681-90doi: 10.1016/0022-2828(89)90609-3.
Aksnes, G., Ellingsen, O., Rutlen, D. L., & Ilebekk, A. (1989). Myocardial K+ repletion and rise in contractility after brief ischemic periods in the pig. Journal of molecular and cellular cardiology, 21(7), 681-90. https://doi.org/10.1016/0022-2828(89)90609-3
Aksnes, G, et al. "Myocardial K+ repletion and rise in contractility after brief ischemic periods in the pig." Journal of molecular and cellular cardiology vol. 21,7 (1989): 681-90. doi: https://doi.org/10.1016/0022-2828(89)90609-3
Aksnes G, Ellingsen O, Rutlen DL, Ilebekk A. Myocardial K+ repletion and rise in contractility after brief ischemic periods in the pig. J Mol Cell Cardiol. 1989 Jul;21(7):681-90. doi: 10.1016/0022-2828(89)90609-3. PMID: 2795661.
Copy Download .nbib Format: NLM
Share it on
Full text links
Elsevier Science

J Mol Cell Cardiol. 1989 Jul;21(7):681-90. doi: 10.1016/0022-2828(89)90609-3.

Myocardial K+ repletion and rise in contractility after brief ischemic periods in the pig.

Journal of molecular and cellular cardiology

G Aksnes, O Ellingsen, D L Rutlen, A Ilebekk

Affiliations

  1. University of Oslo, Institute for Experimental Medical Research, Ullevål Hospital, Norway.

PMID: 2795661 DOI: 10.1016/0022-2828(89)90609-3

Abstract

Potassium loss from the myocardium during brief ischemic periods is well documented, but whether intrinsic myocardial mechanisms restore this loss during reperfusion is unclear. To address this question, we established a shunt from the coronary sinus to the right atrium in seven open-chest pigs. Shunt flow and arterial and coronary sinus potassium concentrations were measured continuously in order to determine myocardial potassium balance. Thirty, 60 and 120 s occlusions of the mid-LAD coronary artery were repeated four times each at 10 min intervals with reproducible metabolic and hemodynamic responses. A myocardial K+ reuptake amounting to 51 to 77% of K+ release during ischemia occurred between 20 and 140 s of reperfusion. The maximal rate of K+ reuptake was 1.4 (0.7 to 3.6), (median and 95% confidence interval), 4.3 (2.5 to 9.6) and 7.3 (4.9 to 13.4) mumol/100 g min after occlusion periods of 30, 60 and 120 s, respectively. Concomitant with the K+ reuptake a progressive rise in LV dP/dt occurred. Adrenoceptor stimulation could not explain these findings since catecholamine release declined during occlusion and reperfusion. We suggest that increased intracellular Na+ concentration in early reperfusion stimulates the Na,K-pump and favours Ca++ entry through Na+/Ca++ exchange, thereby mediating K+ reuptake and the rise in contractility.

Substances

MeSH terms

Publication Types

Grant support

LinkOut - more resources