Display options
Share it on

Nature. 2017 Nov 02;551(7678):92-94. doi: 10.1038/nature24284. Epub 2017 Oct 23.

Association analysis identifies 65 new breast cancer risk loci.

Nature

Kyriaki Michailidou, Sara Lindström, Joe Dennis, Jonathan Beesley, Shirley Hui, Siddhartha Kar, Audrey Lemaçon, Penny Soucy, Dylan Glubb, Asha Rostamianfar, Manjeet K Bolla, Qin Wang, Jonathan Tyrer, Ed Dicks, Andrew Lee, Zhaoming Wang, Jamie Allen, Renske Keeman, Ursula Eilber, Juliet D French, Xiao Qing Chen, Laura Fachal, Karen McCue, Amy E McCart Reed, Maya Ghoussaini, Jason S Carroll, Xia Jiang, Hilary Finucane, Marcia Adams, Muriel A Adank, Habibul Ahsan, Kristiina Aittomäki, Hoda Anton-Culver, Natalia N Antonenkova, Volker Arndt, Kristan J Aronson, Banu Arun, Paul L Auer, François Bacot, Myrto Barrdahl, Caroline Baynes, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Leslie Bernstein, Carl Blomqvist, Natalia V Bogdanova, Stig E Bojesen, Bernardo Bonanni, Anne-Lise Børresen-Dale, Judith S Brand, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Louise Brinton, Per Broberg, Ian W Brock, Annegien Broeks, Angela Brooks-Wilson, Sara Y Brucker, Thomas Brüning, Barbara Burwinkel, Katja Butterbach, Qiuyin Cai, Hui Cai, Trinidad Caldés, Federico Canzian, Angel Carracedo, Brian D Carter, Jose E Castelao, Tsun L Chan, Ting-Yuan David Cheng, Kee Seng Chia, Ji-Yeob Choi, Hans Christiansen, Christine L Clarke, Margriet Collée, Don M Conroy, Emilie Cordina-Duverger, Sten Cornelissen, David G Cox, Angela Cox, Simon S Cross, Julie M Cunningham, Kamila Czene, Mary B Daly, Peter Devilee, Kimberly F Doheny, Thilo Dörk, Isabel Dos-Santos-Silva, Martine Dumont, Lorraine Durcan, Miriam Dwek, Diana M Eccles, Arif B Ekici, A Heather Eliassen, Carolina Ellberg, Mingajeva Elvira, Christoph Engel, Mikael Eriksson, Peter A Fasching, Jonine Figueroa, Dieter Flesch-Janys, Olivia Fletcher, Henrik Flyger, Lin Fritschi, Valerie Gaborieau, Marike Gabrielson, Manuela Gago-Dominguez, Yu-Tang Gao, Susan M Gapstur, José A García-Sáenz, Mia M Gaudet, Vassilios Georgoulias, Graham G Giles, Gord Glendon, Mark S Goldberg, David E Goldgar, Anna González-Neira, Grethe I Grenaker Alnæs, Mervi Grip, Jacek Gronwald, Anne Grundy, Pascal Guénel, Lothar Haeberle, Eric Hahnen, Christopher A Haiman, Niclas Håkansson, Ute Hamann, Nathalie Hamel, Susan Hankinson, Patricia Harrington, Steven N Hart, Jaana M Hartikainen, Mikael Hartman, Alexander Hein, Jane Heyworth, Belynda Hicks, Peter Hillemanns, Dona N Ho, Antoinette Hollestelle, Maartje J Hooning, Robert N Hoover, John L Hopper, Ming-Feng Hou, Chia-Ni Hsiung, Guanmengqian Huang, Keith Humphreys, Junko Ishiguro, Hidemi Ito, Motoki Iwasaki, Hiroji Iwata, Anna Jakubowska, Wolfgang Janni, Esther M John, Nichola Johnson, Kristine Jones, Michael Jones, Arja Jukkola-Vuorinen, Rudolf Kaaks, Maria Kabisch, Katarzyna Kaczmarek, Daehee Kang, Yoshio Kasuga, Michael J Kerin, Sofia Khan, Elza Khusnutdinova, Johanna I Kiiski, Sung-Won Kim, Julia A Knight, Veli-Matti Kosma, Vessela N Kristensen, Ute Krüger, Ava Kwong, Diether Lambrechts, Loic Le Marchand, Eunjung Lee, Min Hyuk Lee, Jong Won Lee, Chuen Neng Lee, Flavio Lejbkowicz, Jingmei Li, Jenna Lilyquist, Annika Lindblom, Jolanta Lissowska, Wing-Yee Lo, Sibylle Loibl, Jirong Long, Artitaya Lophatananon, Jan Lubinski, Craig Luccarini, Michael P Lux, Edmond S K Ma, Robert J MacInnis, Tom Maishman, Enes Makalic, Kathleen E Malone, Ivana Maleva Kostovska, Arto Mannermaa, Siranoush Manoukian, JoAnn E Manson, Sara Margolin, Shivaani Mariapun, Maria Elena Martinez, Keitaro Matsuo, Dimitrios Mavroudis, James McKay, Catriona McLean, Hanne Meijers-Heijboer, Alfons Meindl, Primitiva Menéndez, Usha Menon, Jeffery Meyer, Hui Miao, Nicola Miller, Nur Aishah Mohd Taib, Kenneth Muir, Anna Marie Mulligan, Claire Mulot, Susan L Neuhausen, Heli Nevanlinna, Patrick Neven, Sune F Nielsen, Dong-Young Noh, Børge G Nordestgaard, Aaron Norman, Olufunmilayo I Olopade, Janet E Olson, Håkan Olsson, Curtis Olswold, Nick Orr, V Shane Pankratz, Sue K Park, Tjoung-Won Park-Simon, Rachel Lloyd, Jose I A Perez, Paolo Peterlongo, Julian Peto, Kelly-Anne Phillips, Mila Pinchev, Dijana Plaseska-Karanfilska, Ross Prentice, Nadege Presneau, Darya Prokofyeva, Elizabeth Pugh, Katri Pylkäs, Brigitte Rack, Paolo Radice, Nazneen Rahman, Gadi Rennert, Hedy S Rennert, Valerie Rhenius, Atocha Romero, Jane Romm, Kathryn J Ruddy, Thomas Rüdiger, Anja Rudolph, Matthias Ruebner, Emiel J T Rutgers, Emmanouil Saloustros, Dale P Sandler, Suleeporn Sangrajrang, Elinor J Sawyer, Daniel F Schmidt, Rita K Schmutzler, Andreas Schneeweiss, Minouk J Schoemaker, Fredrick Schumacher, Peter Schürmann, Rodney J Scott, Christopher Scott, Sheila Seal, Caroline Seynaeve, Mitul Shah, Priyanka Sharma, Chen-Yang Shen, Grace Sheng, Mark E Sherman, Martha J Shrubsole, Xiao-Ou Shu, Ann Smeets, Christof Sohn, Melissa C Southey, John J Spinelli, Christa Stegmaier, Sarah Stewart-Brown, Jennifer Stone, Daniel O Stram, Harald Surowy, Anthony Swerdlow, Rulla Tamimi, Jack A Taylor, Maria Tengström, Soo H Teo, Mary Beth Terry, Daniel C Tessier, Somchai Thanasitthichai, Kathrin Thöne, Rob A E M Tollenaar, Ian Tomlinson, Ling Tong, Diana Torres, Thérèse Truong, Chiu-Chen Tseng, Shoichiro Tsugane, Hans-Ulrich Ulmer, Giske Ursin, Michael Untch, Celine Vachon, Christi J van Asperen, David Van Den Berg, Ans M W van den Ouweland, Lizet van der Kolk, Rob B van der Luijt, Daniel Vincent, Jason Vollenweider, Quinten Waisfisz, Shan Wang-Gohrke, Clarice R Weinberg, Camilla Wendt, Alice S Whittemore, Hans Wildiers, Walter Willett, Robert Winqvist, Alicja Wolk, Anna H Wu, Lucy Xia, Taiki Yamaji, Xiaohong R Yang, Cheng Har Yip, Keun-Young Yoo, Jyh-Cherng Yu, Wei Zheng, Ying Zheng, Bin Zhu, Argyrios Ziogas, Elad Ziv, Sunil R Lakhani, Antonis C Antoniou, Arnaud Droit, Irene L Andrulis, Christopher I Amos, Fergus J Couch, Paul D P Pharoah, Jenny Chang-Claude, Per Hall, David J Hunter, Roger L Milne, Montserrat García-Closas, Marjanka K Schmidt, Stephen J Chanock, Alison M Dunning, Stacey L Edwards, Gary D Bader, Georgia Chenevix-Trench, Jacques Simard, Peter Kraft, Douglas F Easton

Affiliations

  1. Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  2. Department of Electron Microscopy/Molecular Pathology, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
  3. Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington, USA.
  4. Program in Genetic Epidemiology and Statistical Genetics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
  5. Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
  6. The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
  7. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
  8. Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Quebec, Canada.
  9. Department of Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
  10. Cancer Genomics Research Laboratory (CGR), Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
  11. Division of Molecular Pathology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
  12. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  13. UQ Centre for Clinical Research, The University of Queensland, Brisbane, Australia.
  14. Cancer Research UK Cambridge Research Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.
  15. Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
  16. Center for Inherited Disease Research (CIDR), Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  17. Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands.
  18. Center for Cancer Epidemiology and Prevention, The University of Chicago, Chicago, Illinois, USA.
  19. Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
  20. Department of Epidemiology, University of California Irvine, Irvine, California, USA.
  21. N. N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus.
  22. Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  23. Department of Public Health Sciences, and Cancer Research Institute, Queen's University, Kingston, Ontario, Canada.
  24. Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
  25. Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  26. Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.
  27. McGill University and Génome Québec Innovation Centre, Montréal, Quebec, Canada.
  28. Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
  29. Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain.
  30. Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain.
  31. Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia.
  32. Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA.
  33. Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
  34. Department of Radiation Oncology, Hannover Medical School, Hannover, Germany.
  35. Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
  36. Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
  37. Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
  38. Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  39. Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy.
  40. Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway.
  41. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  42. Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.
  43. University of Tübingen, Tübingen, Germany.
  44. German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  45. International Agency for Research on Cancer, Lyon, France.
  46. Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
  47. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
  48. Department of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden.
  49. Sheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
  50. Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada.
  51. Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.
  52. Department of Gynecology and Obstetrics, University of Tübingen, Tübingen, Germany.
  53. Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum, Germany.
  54. Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.
  55. Molecular Epidemiology Group, C080, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  56. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
  57. Medical Oncology Department, Hospital Clínico San Carlos, IdISSC (Centro Investigacion Biomedica en Red), CIBERONC (Instituto de Investigación Sanitaria San Carlos), Madrid, Spain.
  58. Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  59. Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Santiago De Compostela, Spain.
  60. Centro de Investigación en Red de Enfermedades Raras (CIBERER) y Centro Nacional de Genotipado (CEGEN-PRB2), Universidad de Santiago de Compostela, Santiago De Compostela, Spain.
  61. Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.
  62. Oncology and Genetics Unit, Instituto de Investigacion Biomedica (IBI) Orense-Pontevedra-Vigo, Xerencia de Xestion Integrada de Vigo-SERGAS, Vigo, Spain.
  63. Hong Kong Hereditary Breast Cancer Family Registry, Happy Valley, Hong Kong.
  64. Department of Pathology, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong.
  65. Division of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
  66. Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
  67. Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea.
  68. Cancer Research Institute, Seoul National University, Seoul, South Korea.
  69. Westmead Institute for Medical Research, University of Sydney, Sydney, Australia.
  70. Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.
  71. Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France.
  72. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
  73. INSERM U1052, Cancer Research Center of Lyon, Lyon, France.
  74. Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK.
  75. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
  76. Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
  77. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
  78. Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
  79. Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
  80. Southampton Clinical Trials Unit, Faculty of Medicine, University of Southampton, Southampton, UK.
  81. Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK.
  82. Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, London, UK.
  83. Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
  84. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  85. Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
  86. Oncology and Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden.
  87. Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russia.
  88. Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
  89. LIFE-Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
  90. David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, California, USA.
  91. Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh Medical School, Edinburgh, UK.
  92. Institute for Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  93. Department of Cancer Epidemiology, Clinical Cancer Registry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  94. Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  95. Department of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
  96. School of Public Health, Curtin University, Perth, Australia.
  97. Moores Cancer Center, University of California San Diego, La Jolla, California, USA.
  98. Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China.
  99. Department of Medical Oncology, University Hospital of Heraklion, Heraklion, Greece.
  100. Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
  101. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
  102. Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.
  103. Department of Medicine, McGill University, Montréal, Quebec, Canada.
  104. Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montréal, Quebec, Canada.
  105. Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA.
  106. Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland.
  107. Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
  108. Centre de Recherche du Centre Hospitalier de Université de Montréal (CHUM), Université de Montréal, Montréal, Quebec, Canada.
  109. Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany.
  110. Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.
  111. Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
  112. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
  113. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
  114. Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  115. Department of Biostatistics & Epidemiology, University of Massachusetts, Amherst, Amherst, Massachusetts, USA.
  116. Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
  117. Translational Cancer Research Area, University of Eastern Finland, Kuopio, Finland.
  118. Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland.
  119. Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland.
  120. Department of Surgery, National University Health System, Singapore, Singapore.
  121. School of Population Health, University of Western Australia, Perth, Australia.
  122. Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
  123. Division of Breast Surgery, Department of Surgery, Kaohsiung Medical University, Kaohsiung, Taiwan.
  124. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
  125. Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.
  126. Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  127. Division of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
  128. Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan.
  129. Department of Gynecology and Obstetrics, University Hospital Ulm, Ulm, Germany.
  130. Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California, USA.
  131. Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California, USA.
  132. Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California, USA.
  133. Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
  134. Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland.
  135. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea.
  136. Department of Surgery, Nagano Matsushiro General Hospital, Nagano, Japan.
  137. School of Medicine, National University of Ireland, Galway, Ireland.
  138. Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
  139. Department of Surgery, Daerim Saint Mary's Hospital, Seoul, South Korea.
  140. Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.
  141. Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
  142. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
  143. Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway.
  144. Department of Surgery, The University of Hong Kong, Pok Fu Lam, Hong Kong.
  145. Department of Surgery, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong.
  146. Vesalius Research Center, VIB, Leuven, Belgium.
  147. Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium.
  148. University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
  149. Department of Surgery, Soonchunhyang University College of Medicine and Soonchunhyang University Hospital, Seoul, South Korea.
  150. Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, South Korea.
  151. Department of Cardiac, Thoracic and Vascular Surgery, National University Health System, Singapore, Singapore.
  152. Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel.
  153. Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
  154. Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Warsaw, Poland.
  155. German Breast Group GmbH, Neu Isenburg, Germany.
  156. Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK.
  157. Institute of Population Health, University of Manchester, Manchester, UK.
  158. Division of Public Health Sciences, Epidemiology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  159. Research Centre for Genetic Engineering and Biotechnology "Georgi D. Efremov", Macedonian Academy of Sciences and Arts, Skopje, Republic of Macedonia.
  160. Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy.
  161. Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  162. Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
  163. Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia.
  164. Department of Family Medicine and Public Health, University of California San Diego, La Jolla, California, USA.
  165. Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.
  166. Anatomical Pathology, The Alfred Hospital, Melbourne, Australia.
  167. Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany.
  168. Servicio de Anatomía Patológica, Hospital Monte Naranco, Oviedo, Spain.
  169. Gynaecological Cancer Research Centre, Department of Women's Cancer, Institute for Women's Health, University College London, London, UK.
  170. Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia.
  171. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
  172. Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada.
  173. Université Paris Sorbonne Cité, INSERM UMR-S1147, Paris, France.
  174. Leuven Multidisciplinary Breast Center, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
  175. Department of Surgery, Seoul National University College of Medicine, Seoul, South Korea.
  176. Center for Clinical Cancer Genetics and Global Health, The University of Chicago, Chicago, Illinois, USA.
  177. University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque, New Mexico, USA.
  178. The Curtin UWA Centre for Genetic Origins of Health and Disease, Curtin University and University of Western Australia, Perth, Australia.
  179. Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain.
  180. IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy.
  181. Peter MacCallum Cancer Center, Melbourne, Australia.
  182. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Australia.
  183. Department of Medicine, St Vincent's Hospital, The University of Melbourne, Fitzroy, Australia.
  184. Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland.
  185. Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre Oulu, Oulu, Finland.
  186. Department of Gynecology and Obstetrics, Ludwig-Maximilians University of Munich, Munich, Germany.
  187. Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy.
  188. Section of Cancer Genetics, The Institute of Cancer Research, London, UK.
  189. Medical Oncology Department, Hospital Universitario Puerta de Hierro, Madrid, Spain.
  190. Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA.
  191. Institute of Pathology, Staedtisches Klinikum Karlsruhe, Karlsruhe, Germany.
  192. Department of Surgery, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
  193. Hereditary Cancer Clinic, University Hospital of Heraklion, Heraklion, Greece.
  194. Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, USA.
  195. National Cancer Institute, Bangkok, Thailand.
  196. Research Oncology, Guy's Hospital, King's College London, London, UK.
  197. National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany.
  198. Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA.
  199. Division of Molecular Medicine, Pathology North, John Hunter Hospital, Newcastle, Australia.
  200. Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Callaghan, Australia.
  201. Department of Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.
  202. School of Public Health, China Medical University, Taichung, Taiwan.
  203. Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
  204. Division of Cancer Prevention, National Cancer Institute, Rockville, Maryland, USA.
  205. Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Australia.
  206. Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada.
  207. School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.
  208. Saarland Cancer Registry, Saarbrücken, Germany.
  209. Department of Obstetrics and Gynaecology, University of Melbourne and the Royal Women's Hospital, Melbourne, Australia.
  210. Division of Breast Cancer Research, The Institute of Cancer Research, London, UK.
  211. Epigenetic and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, USA.
  212. Cancer Center, Kuopio University Hospital, Kuopio, Finland.
  213. Institute of Clinical Medicine, Oncology, University of Eastern Finland, Kuopio, Finland.
  214. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
  215. National Cancer Institute, Ministry of Public Health, Nonthaburi, Thailand.
  216. Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
  217. Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
  218. Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota, Colombia.
  219. Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
  220. Frauenklinik der Stadtklinik Baden-Baden, Baden-Baden, Germany.
  221. Cancer Registry of Norway, Oslo, Norway.
  222. Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
  223. Department of Gynecology and Obstetrics, Helios Clinics Berlin-Buch, Berlin, Germany.
  224. Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.
  225. Family Cancer Clinic, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
  226. Division of Biomedical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.
  227. Department of Gynaecology and Obstetrics, University of Ulm, Ulm, Germany.
  228. Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina, USA.
  229. Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA.
  230. Subang Jaya Medical Centre, Subang Jaya, Selangor, Malaysia.
  231. Seoul National University College of Medicine, Seoul, South Korea.
  232. Armed Forces Capital Hospital, Seongnam, South Korea.
  233. Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
  234. Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
  235. Department of Medicine, Institute for Human Genetics, UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, USA.
  236. Pathology Queensland, The Royal Brisbane and Women's Hospital, Brisbane 4029, Australia.
  237. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
  238. Center for Genomic Medicine, Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.
  239. University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  240. Department of Oncology, Södersjukhuset, Stockholm, Sweden.
  241. Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

PMID: 29059683 PMCID: PMC5798588 DOI: 10.1038/nature24284

Abstract

Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. Here we report the results of a genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry. We identified 65 new loci that are associated with overall breast cancer risk at P < 5 × 10

References

  1. Cell Commun Signal. 2013 Dec 20;11:97 - PubMed
  2. Bioinformatics. 2012 May 15;28(10):1359-67 - PubMed
  3. Nat Genet. 2014 Aug;46(8):886-90 - PubMed
  4. Cell. 2013 Nov 7;155(4):934-47 - PubMed
  5. Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50 - PubMed
  6. Nature. 2015 Feb 19;518(7539):317-30 - PubMed
  7. Nat Genet. 2009 Jun;41(6):724-8 - PubMed
  8. Nucleic Acids Res. 2009 Jan;37(Database issue):D674-9 - PubMed
  9. PLoS Comput Biol. 2016 Aug 18;12 (8):e1004751 - PubMed
  10. PLoS Biol. 2011 Apr;9(4):e1001046 - PubMed
  11. Cell. 2014 Dec 18;159(7):1665-80 - PubMed
  12. Genomics. 2011 Jul;98(1):1-8 - PubMed
  13. J Comput Biol. 2004;11(2-3):377-94 - PubMed
  14. Hum Mutat. 2013 Jan;34(1):57-65 - PubMed
  15. Nucleic Acids Res. 2009 Jul;37(Web Server issue):W340-4 - PubMed
  16. Nat Rev Genet. 2010 Dec;11(12):843-54 - PubMed
  17. PLoS Genet. 2011 Jun;7(6):e1002101 - PubMed
  18. Nature. 2012 Nov 1;491(7422):56-65 - PubMed
  19. Nat Commun. 2015 Jan 19;6:5890 - PubMed
  20. BMC Bioinformatics. 2011 Aug 04;12:323 - PubMed
  21. PLoS One. 2010 Nov 15;5(11):e13984 - PubMed
  22. Genome Biol. 2005;6(1):R2 - PubMed
  23. Genome Res. 2003 Nov;13(11):2498-504 - PubMed
  24. Nat Commun. 2014 Sep 23;4:4999 - PubMed
  25. Genome Res. 2009 Sep;19(9):1553-61 - PubMed
  26. Cell. 2013 Jan 31;152(3):633-41 - PubMed
  27. Nat Methods. 2014 Apr;11(4):361-2 - PubMed
  28. Nucleic Acids Res. 2014 Jan;42(Database issue):D1001-6 - PubMed
  29. Am J Hum Genet. 2007 Dec;81(6):1278-83 - PubMed
  30. Genome Res. 2014 Jan;24(1):1-13 - PubMed
  31. Genet Epidemiol. 2010 Jul;34(5):463-8 - PubMed
  32. Nat Genet. 2000 Sep;26(1):122-7 - PubMed
  33. Bioinformatics. 2011 Jan 1;27(1):95-102 - PubMed
  34. Nat Genet. 2012 Jul 22;44(8):955-9 - PubMed
  35. Bioinformation. 2013 Apr 30;9(8):394-400 - PubMed
  36. Cell. 2015 Oct 8;163(2):506-19 - PubMed
  37. PLoS One. 2012;7(10):e46688 - PubMed
  38. Genome Biol. 2010 Jan 12;11(1):R3 - PubMed
  39. Bioinformatics. 2010 Sep 1;26(17):2190-1 - PubMed
  40. Nat Genet. 2006 Feb;38(2):209-13 - PubMed
  41. Genome Res. 2012 Sep;22(9):1760-74 - PubMed
  42. Nucleic Acids Res. 2011 Sep 1;39(17):e118 - PubMed
  43. Nat Methods. 2010 Apr;7(4):248-9 - PubMed
  44. PLoS Genet. 2012;8(2):e1002532 - PubMed
  45. Cancer Res. 2004 Sep 1;64(17):6075-81 - PubMed
  46. Genome Biol. 2011;12(4):R41 - PubMed
  47. Bioinformatics. 2010 Mar 15;26(6):841-2 - PubMed
  48. BMC Bioinformatics. 2010 Mar 16;11:134 - PubMed
  49. Nat Rev Cancer. 2010 Feb;10(2):116-29 - PubMed
  50. Nat Genet. 2015 Nov;47(11):1228-35 - PubMed
  51. Nature. 2014 Mar 27;507(7493):455-461 - PubMed
  52. Nucleic Acids Res. 2005 Jan 1;33(Database issue):D428-32 - PubMed
  53. Genet Epidemiol. 2010 Dec;34(8):816-34 - PubMed
  54. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D493-6 - PubMed
  55. Nucleic Acids Res. 2009 May;37(9):e67 - PubMed
  56. Proc Natl Acad Sci U S A. 2014 May 27;111(21):E2191-9 - PubMed
  57. Nature. 2012 Apr 18;486(7403):346-52 - PubMed
  58. Tumour Biol. 2014 Aug;35(8):7699-705 - PubMed
  59. Nature. 2012 Oct 4;490(7418):61-70 - PubMed
  60. Nat Genet. 2014 Mar;46(3):310-5 - PubMed
  61. Nat Protoc. 2009;4(7):1073-81 - PubMed
  62. Nat Commun. 2016 May 10;7:11479 - PubMed
  63. Nat Genet. 2012 Dec;44(12 ):1294-301 - PubMed
  64. PLoS Genet. 2014 Apr 17;10(4):e1004234 - PubMed
  65. Nature. 2016 May 02;534(7605):47-54 - PubMed
  66. Nat Genet. 2013 Apr;45(4):353-61, 361e1-2 - PubMed
  67. Genome Res. 2003 Sep;13(9):2129-41 - PubMed
  68. Nat Genet. 2015 Apr;47(4):373-80 - PubMed
  69. Nat Genet. 2000 May;25(1):25-9 - PubMed
  70. Cell. 2009 Feb 6;136(3):535-50 - PubMed
  71. Cancer Epidemiol Biomarkers Prev. 2017 Jan;26(1):126-135 - PubMed
  72. Bioinformatics. 2012 May 15;28(10):1353-8 - PubMed
  73. PLoS Genet. 2009 Jun;5(6):e1000529 - PubMed
  74. Cancer Biol Ther. 2004 Jan;3(1):36-41 - PubMed
  75. J Natl Cancer Inst. 2013 Apr 17;105(8):573-9 - PubMed

Substances

MeSH terms

Publication Types

Grant support