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Christiansen H, Lampert F. Tumorcytogenetik und Prognose beim Neuroblastom. [Tumor cytogenetics and prognosis in neuroblastoma]. Monatsschr Kinderheilkd. 1989;137(10):666-71
Christiansen, H., & Lampert, F. (1989). Tumorcytogenetik und Prognose beim Neuroblastom. [Tumor cytogenetics and prognosis in neuroblastoma]. Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 137(10), 666-71.
Christiansen, H, and Lampert, F. "Tumorcytogenetik und Prognose beim Neuroblastom." [Tumor cytogenetics and prognosis in neuroblastoma]. Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde vol. 137,10 (1989): 666-71.
Christiansen H, Lampert F. Tumorcytogenetik und Prognose beim Neuroblastom. [Tumor cytogenetics and prognosis in neuroblastoma]. Monatsschr Kinderheilkd. 1989 Oct;137(10):666-71. German. PMID: 2586532.
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Monatsschr Kinderheilkd. 1989 Oct;137(10):666-71.

[Tumor cytogenetics and prognosis in neuroblastoma].

Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde

[Article in German]
H Christiansen, F Lampert

Affiliations

  1. Abteilung Allgemeine Pädiatrie, Justus-Liebig-Universität Giessen.

PMID: 2586532

Abstract

In 40 children with neuroblastoma of different clinical stages the tumorkaryotype was determined at onset (n = 30) or at relapse (n = 10) of disease after short-term culture of tumor tissues or bone marrow aspirates. None of the 10 stage I, II, and IVs tumors revealed a chromosome 1p aberration, in contrast to stage III and IV tumors where this abnormality was encountered in 25 (=83%) of 30 patients. Amplification of the proto-oncogene N-myc in the tumor-DNA could not be detected in stage I, II and IVs, was however present in 53% of stage III and IV tumors. Cytogenetic phenomena of gene amplification such as Double minutes (DMs) and Homogeneously Staining Regions (HSRs) correlated with N-myc amplification. About 50% of stage III and IV tumors had chromosome numbers in the neardiploid range whereas prognostically favourable tumors were characterized by hyperploid chromosomal numbers mainly in the triploid range. Life-table analysis according to Kaplan-Meier showed a probability of surviving in about 80% of patients with a normal morphology of chromosome 1 in their tumor cells, compared to about 60% in the absence of N-myc oncogene amplification and of about 50%, if aneuploidy is detected. Thus, we think, the presence or absence of chromosome 1p aberration in the tumorkaryotype is the most sensitive discriminator for outcome in children with neuroblastoma.

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