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Ackerman CM, Chang CJ. Copper signaling in the brain and beyond. J Biol Chem. 2017;293(13):4628-4635doi: 10.1074/jbc.R117.000176.
Ackerman, C. M., & Chang, C. J. (2018). Copper signaling in the brain and beyond. The Journal of biological chemistry, 293(13), 4628-4635. https://doi.org/10.1074/jbc.R117.000176
Ackerman, Cheri M, and Chang, Christopher J. "Copper signaling in the brain and beyond." The Journal of biological chemistry vol. 293,13 (2018): 4628-4635. doi: https://doi.org/10.1074/jbc.R117.000176
Ackerman CM, Chang CJ. Copper signaling in the brain and beyond. J Biol Chem. 2018 Mar 30;293(13):4628-4635. doi: 10.1074/jbc.R117.000176. Epub 2017 Oct 30. PMID: 29084848; PMCID: PMC5880129.
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J Biol Chem. 2018 Mar 30;293(13):4628-4635. doi: 10.1074/jbc.R117.000176. Epub 2017 Oct 30.

Copper signaling in the brain and beyond.

The Journal of biological chemistry

Cheri M Ackerman, Christopher J Chang

Affiliations

  1. Departments of Chemistry, Berkeley, California 94720-1460.
  2. Departments of Chemistry, Berkeley, California 94720-1460; Molecular and Cell Biology, Berkeley, California 94720-1460; Howard Hughes Medical Institute, University of California Berkeley, Berkeley, California 94720-1460; Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720. Electronic address: [email protected].

PMID: 29084848 PMCID: PMC5880129 DOI: 10.1074/jbc.R117.000176

Abstract

Transition metals have been recognized and studied primarily in the context of their essential roles as structural and metabolic cofactors for biomolecules that compose living systems. More recently, an emerging paradigm of transition-metal signaling, where dynamic changes in transitional metal pools can modulate protein function, cell fate, and organism health and disease, has broadened our view of the potential contributions of these essential nutrients in biology. Using copper as a canonical example of transition-metal signaling, we highlight key experiments where direct measurement and/or visualization of dynamic copper pools, in combination with biochemical, physiological, and behavioral studies, have deciphered sources, targets, and physiological effects of copper signals.

Keywords: cancer biology; copper signaling; copper transport; immunology; lipolysis; metal homeostasis; neurobiology

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