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Mathog RH, Capps MJ. Ototoxic interactions of ethacrynic acid and streptomycin. Ann Otol Rhinol Laryngol. 1977;86(2):158-63doi: 10.1177/000348947708600204.
Mathog, R. H., & Capps, M. J. (1977). Ototoxic interactions of ethacrynic acid and streptomycin. The Annals of otology, rhinology, and laryngology, 86(2), 158-63. https://doi.org/10.1177/000348947708600204
Mathog, R H, and Capps, M J. "Ototoxic interactions of ethacrynic acid and streptomycin." The Annals of otology, rhinology, and laryngology vol. 86,2 (1977): 158-63. doi: https://doi.org/10.1177/000348947708600204
Mathog RH, Capps MJ. Ototoxic interactions of ethacrynic acid and streptomycin. Ann Otol Rhinol Laryngol. 1977 Mar-Apr;86(2):158-63. doi: 10.1177/000348947708600204. PMID: 300585.
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Ann Otol Rhinol Laryngol. 1977 Mar-Apr;86(2):158-63. doi: 10.1177/000348947708600204.

Ototoxic interactions of ethacrynic acid and streptomycin.

The Annals of otology, rhinology, and laryngology

R H Mathog, M J Capps

PMID: 300585 DOI: 10.1177/000348947708600204

Abstract

Various aminoglycoside antibiotics and potent diuretics are known to depress cochlear and vestibular function. Several clinical and research studies suggest that the drugs administered together produce enhanced ototoxicity. The present series of experiments determines the depressive effects of ethacrynic acid and streptomycin, alone or in combination, upon the vestibular system of the cat. The changes in function, when quantified, indicate an addition, rather than a potentiation of toxicity, and suggest different sites of action.

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