Display options
Cite
Yeh BK, Gosselin AJ, Swaye PS, et al. Sodium nitroprusside as a coronary vasodilator in man. I. Effect of intracoronary sodium nitroprusside on coronary arteries, angina pectoris, and coronary blood flow. Am Heart J. 1977;93(5):610-6doi: 10.1016/s0002-8703(77)80012-4.
Yeh, B. K., Gosselin, A. J., Swaye, P. S., Larsen, P. B., Gentsch, T. O., Traad, E. A., & Faraldo, A. R. (1977). Sodium nitroprusside as a coronary vasodilator in man. I. Effect of intracoronary sodium nitroprusside on coronary arteries, angina pectoris, and coronary blood flow. American heart journal, 93(5), 610-6. https://doi.org/10.1016/s0002-8703(77)80012-4
Yeh, B K, et al. "Sodium nitroprusside as a coronary vasodilator in man. I. Effect of intracoronary sodium nitroprusside on coronary arteries, angina pectoris, and coronary blood flow." American heart journal vol. 93,5 (1977): 610-6. doi: https://doi.org/10.1016/s0002-8703(77)80012-4
Yeh BK, Gosselin AJ, Swaye PS, Larsen PB, Gentsch TO, Traad EA, Faraldo AR. Sodium nitroprusside as a coronary vasodilator in man. I. Effect of intracoronary sodium nitroprusside on coronary arteries, angina pectoris, and coronary blood flow. Am Heart J. 1977 May;93(5):610-6. doi: 10.1016/s0002-8703(77)80012-4. PMID: 300557.
Copy Download .nbib Format: NLM
Share it on
Full text links
Elsevier Science

Am Heart J. 1977 May;93(5):610-6. doi: 10.1016/s0002-8703(77)80012-4.

Sodium nitroprusside as a coronary vasodilator in man. I. Effect of intracoronary sodium nitroprusside on coronary arteries, angina pectoris, and coronary blood flow.

American heart journal

B K Yeh, A J Gosselin, P S Swaye, P B Larsen, T O Gentsch, E A Traad, A R Faraldo

PMID: 300557 DOI: 10.1016/s0002-8703(77)80012-4

Abstract

The effect of the intra-arterial injection of 5 to 10 microng of sodium nitroprusside on the caliber of normal and diseased coronary arteries was evaluated in 21 patients during diagnostic cardiac catheterization. In addition, the effect of intra-graft injection of 5 microng of the same agent on the blood flow in aorta-right coronary artery saphenous vein bypass grafts was also evaluated intra-operatively in two patients. The compound induced an increase in the caliber of both normal and stenosed coronary arteries as well as an increase of flow in the grafts. Consistent with measurements of coronary flow response to sodium nitroprusside, angina pectoris which developed in four patients during cardiac catheterization was immediately relieved and the ischemic ST-segment depression significantly reversed after injection of 5 to 10 microng of the drug into the left main coronary artery. Within the dose range used, the drug caused no significant effect on systemic blood pressure or apparently deleterious electrophysiologic changes. No side effects were observed. We conclude that the primary direct action of sodium nitroprusside in the human coronary artery is vasodilatory.

Similar articles

Substances

MeSH terms

Publication Types

LinkOut - more resources