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Pasquini R, Monarca S, Scassellati Sforzolini G, et al. Urinary excretion of mutagens, thioethers and D-glucaric acid in workers exposed to bitumen fumes. Int Arch Occup Environ Health. 1989;61(5):335-40doi: 10.1007/BF00409389.
Pasquini, R., Monarca, S., Scassellati Sforzolini, G., Savino, A., Bauleo, F. A., & Angeli, G. (1989). Urinary excretion of mutagens, thioethers and D-glucaric acid in workers exposed to bitumen fumes. International archives of occupational and environmental health, 61(5), 335-40. https://doi.org/10.1007/BF00409389
Pasquini, R, et al. "Urinary excretion of mutagens, thioethers and D-glucaric acid in workers exposed to bitumen fumes." International archives of occupational and environmental health vol. 61,5 (1989): 335-40. doi: https://doi.org/10.1007/BF00409389
Pasquini R, Monarca S, Scassellati Sforzolini G, Savino A, Bauleo FA, Angeli G. Urinary excretion of mutagens, thioethers and D-glucaric acid in workers exposed to bitumen fumes. Int Arch Occup Environ Health. 1989;61(5):335-40. doi: 10.1007/BF00409389. PMID: 2707871.
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Int Arch Occup Environ Health. 1989;61(5):335-40. doi: 10.1007/BF00409389.

Urinary excretion of mutagens, thioethers and D-glucaric acid in workers exposed to bitumen fumes.

International archives of occupational and environmental health

R Pasquini, S Monarca, G Scassellati Sforzolini, A Savino, F A Bauleo, G Angeli

Affiliations

  1. Department of Hygiene, University of Perugia, Italy.

PMID: 2707871 DOI: 10.1007/BF00409389

Abstract

The authors carried out biological monitoring of the mutagenic/carcinogenic hazards associated with exposure to bitumen fumes during paving operations, analysing some biological parameters in the urine of a group of exposed workers. The urine samples were studied for mutagenicity by the Ames test and for thioethers concentration. D-Glucaric acid urine excretion was also determined to investigate the enzymatic induction potential of bitumens. Even though, in a previous environmental monitoring phase, a low content of mutagenic/carcinogenic compounds was found in bitumen and air samples, urinary mutagenicity data of exposed workers were statistically higher than those of a group of unexposed subjects. The urinary mutagenicity increased further if exposure to bitumens was associated with cigarette smoking. Thioethers were higher only in subjects exposed simultaneously to bitumens and cigarettes. D-Glucaric acid excretion did not increase significantly. The authors think that this type of coupled environmental and biological monitoring is a valid tool for a better evaluation of the mutagenic/carcinogenic exposure to bitumens or similar complex mixtures.

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References

  1. Rev Epidemiol Sante Publique. 1985;33(4-5):255-61 - PubMed
  2. Lancet. 1979 Jun 9;1(8128):1250-1 - PubMed
  3. Int Arch Occup Environ Health. 1977 Apr 15;39(1):45-51 - PubMed
  4. Mutat Res. 1981 Jun;85(3):97-108 - PubMed
  5. Int Arch Occup Environ Health. 1982;50(4):387-95 - PubMed
  6. Drug Metab Rev. 1979;9(2):221-36 - PubMed
  7. Br J Ind Med. 1981 May;38(2):187-90 - PubMed
  8. Br J Ind Med. 1985 Jul;42(7):481-7 - PubMed
  9. Int Arch Occup Environ Health. 1982;50(4):359-69 - PubMed
  10. Mutat Res. 1980 Sep;79(1):45-52 - PubMed
  11. IARC Monogr Eval Carcinog Risk Chem Hum. 1985 Sep;37:1-268 - PubMed
  12. Teratog Carcinog Mutagen. 1982;2(2):137-50 - PubMed
  13. Mutat Res. 1983 Mar;108(1-3):67-79 - PubMed
  14. Mutat Res. 1975 Dec;31(6):347-64 - PubMed
  15. Arch Environ Health. 1981 Nov-Dec;36(6):289-97 - PubMed
  16. Eur J Clin Pharmacol. 1975 Jun 13;8(5):327-36 - PubMed
  17. Lancet. 1971 Mar 20;1(7699):572-5 - PubMed
  18. Int Arch Occup Environ Health. 1987;59(4):393-402 - PubMed
  19. Clin Chem. 1981 Mar;27(3):422-6 - PubMed
  20. Clin Chim Acta. 1983 Mar 14;128(2-3):337-47 - PubMed
  21. Clin Chim Acta. 1983 Mar 14;128(2-3):349-58 - PubMed
  22. Int Arch Occup Environ Health. 1984;54(4):345-54 - PubMed
  23. Int Arch Occup Environ Health. 1983;52(1):11-6 - PubMed
  24. Carcinogenesis. 1982;3(9):1077-9 - PubMed
  25. Scand J Work Environ Health. 1980 Sep;6(3):216-20 - PubMed
  26. Mutat Res. 1985 Mar;155(3):143-55 - PubMed
  27. Carcinogenesis. 1987 Mar;8(3):363-7 - PubMed
  28. Int Arch Occup Environ Health. 1979 Jun 15;43(3):159-66 - PubMed
  29. Int Arch Occup Environ Health. 1977;38(3):209-20 - PubMed
  30. Br J Ind Med. 1981 Feb;38(1):98-100 - PubMed
  31. Mutat Res. 1985 Dec;158(3):149-57 - PubMed
  32. Am J Epidemiol. 1986 Dec;124(6):884-93 - PubMed
  33. Proc Natl Acad Sci U S A. 1977 Aug;74(8):3555-9 - PubMed
  34. Public Health. 1986 Nov;100(6):392-8 - PubMed
  35. Clin Chem. 1982 Jan;28(1):248-50 - PubMed
  36. Br J Ind Med. 1982 Nov;39(4):401-3 - PubMed
  37. Br J Ind Med. 1985 Oct;42(10):691-9 - PubMed
  38. Mutat Res. 1983 May;113(3-4):173-215 - PubMed
  39. J Toxicol Environ Health. 1981 Jul-Aug;8(1-2):95-103 - PubMed
  40. Int Arch Occup Environ Health. 1985;56(4):275-84 - PubMed
  41. Mutat Res. 1984 Jun;136(3):201-7 - PubMed
  42. Ann Occup Hyg. 1981;24(1):77-92 - PubMed
  43. Mutat Res. 1985 Aug-Sep;157(2-3):227-33 - PubMed
  44. Int Arch Occup Environ Health. 1982 Feb;49(3-4):223-39 - PubMed
  45. J Appl Toxicol. 1984 Aug;4(4):163-9 - PubMed
  46. Br J Ind Med. 1978 Aug;35(3):232-4 - PubMed
  47. Biochem Pharmacol. 1973 Mar 15;22(6):743-7 - PubMed
  48. Br J Ind Med. 1986 Jan;43(1):68-9 - PubMed
  49. Int Arch Occup Environ Health. 1980;46(2):99-109 - PubMed

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