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J Pharm Sci. 2018 Feb;107(2):654-661. doi: 10.1016/j.xphs.2017.09.026. Epub 2017 Oct 05.

Composite Alginate-Hyaluronan Sponges for the Delivery of Tranexamic Acid in Postextractive Alveolar Wounds.

Journal of pharmaceutical sciences

Ovidio Catanzano, Vittoria D'Esposito, Pietro Formisano, Joshua S Boateng, Fabiana Quaglia

Affiliations

  1. Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, Naples 80131, Italy; Department of Pharmaceutical, Chemical and Environmental Sciences, Faculty of Engineering and Science, University of Greenwich, Medway, Central Avenue, Chatham Maritime, Kent ME4 4TB, UK. Electronic address: [email protected].
  2. Department of Translational Medical Sciences, University of Naples Federico II, Via S. Pansini 5, Naples 80131, Italy.
  3. Department of Pharmaceutical, Chemical and Environmental Sciences, Faculty of Engineering and Science, University of Greenwich, Medway, Central Avenue, Chatham Maritime, Kent ME4 4TB, UK.
  4. Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, Naples 80131, Italy.

PMID: 28987501 DOI: 10.1016/j.xphs.2017.09.026

Abstract

The management of wounds in patients on anticoagulant therapy who require oral surgical procedures is problematic and often results in a nonsatisfactory healing process. Here, we report a method to prepare an advanced dressing able to avoid uncontrolled bleeding by occluding the postextractive alveolar wounds, and simultaneously, capable of a fast release of tranexamic acid (TA). Composite alginate/hyaluronan (ALG/HA) sponge dressings loaded with TA were prepared by a straightforward internal gelation method followed by a freeze-drying step. Both blank and drug-loaded sponges were soft, flexible, and elegant in appearance and nonbrittle in nature. Scanning electron microscopy analysis confirmed the porous nature of these dressings. The integration of HA influenced the microstructure, reducing the porosity, modifying the water uptake kinetic, and increasing the resistance to compression. TA release from ALG/HA sponges showed a controlled release up to 3 h, and it was faster in the presence of HA. Finally, an in vitro clotting test performed on human whole blood confirmed that the TA-loaded sponges significantly reduce the blood clotting index by 30% compared with ALG/HA

Copyright © 2018 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Keywords: alginate; biodegradable polymers; controlled delivery; mechanical properties; wound healing

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