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Dermatol Ther (Heidelb). 2017 Dec;7(4):563-570. doi: 10.1007/s13555-017-0206-1. Epub 2017 Oct 19.

Acute Localized Exanthematous Pustulosis (ALEP): Review of Literature with Report of Case Caused by Amoxicillin-Clavulanic Acid.

Dermatology and therapy

Alessia Villani, Antonello Baldo, Gaia De Fata Salvatores, Vincenzo Desiato, Fabio Ayala, Carlo Donadio

Affiliations

  1. Section of Dermatology, Department of Clinical Medicine and Surgery, Dermatology Unit, University of Naples Federico II, Naples, Italy. [email protected].
  2. Section of Dermatology, Department of Clinical Medicine and Surgery, Dermatology Unit, University of Naples Federico II, Naples, Italy.

PMID: 29052100 PMCID: PMC5698205 DOI: 10.1007/s13555-017-0206-1

Abstract

Acute localized exanthematous pustulosis (ALEP) is a localized form of acute generalized exanthematous pustulosis, characterized by acute onset of multiple nonfollicular, pinhead-sized, sterile pustules following drug administration. Antibiotics, especially β-lactams and macrolides, have been implicated in the majority of cases, although eruption after nonsteroidal antiinflammatory drugs and many other medications has also been reported. Skin reaction arises quickly within a few hours, resolving rapidly within a few days without treatment, and it is usually accompanied by fever and neutrophilic leukocytosis. We report herein all cases of ALEP described in literature, adding the case of a 35-year-old woman admitted to our hospital with outbreak of erythematous pustules on her face, neck, and chest after amoxicillin-clavulanic acid treatment.

Keywords: AGEP; ALEP; Amoxicillin–clavulanic acid; Corticosteroids; Exanthematous pustulosis; Hypersensitivity reaction; Sterile pustules

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