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Coronel R, Fiolet JW, Wilms-Schopman JG, et al. Distribution of extracellular potassium and electrophysiologic changes during two-stage coronary ligation in the isolated, perfused canine heart. Circulation. 1989;80(1):165-77doi: 10.1161/01.cir.80.1.165.
Coronel, R., Fiolet, J. W., Wilms-Schopman, J. G., Opthof, T., Schaapherder, A. F., & Janse, M. J. (1989). Distribution of extracellular potassium and electrophysiologic changes during two-stage coronary ligation in the isolated, perfused canine heart. Circulation, 80(1), 165-77. https://doi.org/10.1161/01.cir.80.1.165
Coronel, R, et al. "Distribution of extracellular potassium and electrophysiologic changes during two-stage coronary ligation in the isolated, perfused canine heart." Circulation vol. 80,1 (1989): 165-77. doi: https://doi.org/10.1161/01.cir.80.1.165
Coronel R, Fiolet JW, Wilms-Schopman JG, Opthof T, Schaapherder AF, Janse MJ. Distribution of extracellular potassium and electrophysiologic changes during two-stage coronary ligation in the isolated, perfused canine heart. Circulation. 1989 Jul;80(1):165-77. doi: 10.1161/01.cir.80.1.165. PMID: 2736748.
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Circulation. 1989 Jul;80(1):165-77. doi: 10.1161/01.cir.80.1.165.

Distribution of extracellular potassium and electrophysiologic changes during two-stage coronary ligation in the isolated, perfused canine heart.

Circulation

R Coronel, J W Fiolet, J G Wilms-Schopman, T Opthof, A F Schaapherder, M J Janse

Affiliations

  1. Department of Clinical and Experimental Cardiology, Academic Medical Centre, Amsterdam, The Netherlands.

PMID: 2736748 DOI: 10.1161/01.cir.80.1.165

Abstract

We studied the relation between [K+]o and the electrophysiologic changes during a "Harris two-stage ligation," which is an occlusion of a coronary artery, preceded by a 30-minute period of 50% reduction of flow through the artery. This two-stage ligation has been reported to be antiarrhythmic. Local direct current electrograms and [K+]o signals from up to 48 intramural sites were simultaneously recorded in isolated, perfused dog hearts. A second period of one-stage ligation was compared with a consecutive two-stage ligation because reproducibility in [K+]o and electrophysiologic changes are established only after the first period of ischemia. In control experiments, no difference was found between the second and third period of one-stage ligation in the electrophysiologic changes and in increases in [K+]o. After complete occlusion during two-stage ligation, activation block in the ischemic tissue occurred about 6 minutes earlier than during one-stage ligation, but the average potassium concentration at which block occurred was identical. This [K+]o during total ischemia was achieved earlier during two-stage ligation than during one-stage ligation. No indication was found for a large decrease of intracellular potassium content during the period of low flow perfusion. Early activation block may explain the previously reported reduced incidence of ventricular fibrillation during two-stage ligation.

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