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Creutzig U, Ritter J, Niederbiermann-Koczy G, et al. Prognostische Bedeutung der Eosinophilie bei Kindern mit akuter myeloischer Leukämie in den Studien AML-BFM-78 und -83. [Prognostic significance of eosinophilia in children with acute myeloid leukemia in the studies AML-BFM-78 and -83]. Klin Padiatr. 1989;201(4):220-6doi: 10.1055/s-2007-1025307.
Creutzig, U., Ritter, J., Niederbiermann-Koczy, G., Harbott, J., & Schellong, G. (1989). Prognostische Bedeutung der Eosinophilie bei Kindern mit akuter myeloischer Leukämie in den Studien AML-BFM-78 und -83. [Prognostic significance of eosinophilia in children with acute myeloid leukemia in the studies AML-BFM-78 and -83]. Klinische Padiatrie, 201(4), 220-6. https://doi.org/10.1055/s-2007-1025307
Creutzig, U, et al. "Prognostische Bedeutung der Eosinophilie bei Kindern mit akuter myeloischer Leukämie in den Studien AML-BFM-78 und -83." [Prognostic significance of eosinophilia in children with acute myeloid leukemia in the studies AML-BFM-78 and -83]. Klinische Padiatrie vol. 201,4 (1989): 220-6. doi: https://doi.org/10.1055/s-2007-1025307
Creutzig U, Ritter J, Niederbiermann-Koczy G, Harbott J, Schellong G. Prognostische Bedeutung der Eosinophilie bei Kindern mit akuter myeloischer Leukämie in den Studien AML-BFM-78 und -83. [Prognostic significance of eosinophilia in children with acute myeloid leukemia in the studies AML-BFM-78 and -83]. Klin Padiatr. 1989 Jul-Aug;201(4):220-6. doi: 10.1055/s-2007-1025307. German. PMID: 2674528.
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Georg Thieme Verlag Stuttgart, New York

Klin Padiatr. 1989 Jul-Aug;201(4):220-6. doi: 10.1055/s-2007-1025307.

[Prognostic significance of eosinophilia in children with acute myeloid leukemia in the studies AML-BFM-78 and -83].

Klinische Padiatrie

[Article in German]
U Creutzig, J Ritter, G Niederbiermann-Koczy, J Harbott, G Schellong

Affiliations

  1. Universitäts-Kinderklinik Münster.

PMID: 2674528 DOI: 10.1055/s-2007-1025307

Abstract

Initial eosinophilia (greater than or equal to 3%) in the bone marrow was found in 73 out of 269 (27%) patients studied in AML studies BFM-78 and -83. It was predominantly seen in children with FAB types M2 (44%) and M4 (41%). Atypical eosinophils were mostly found in FAB type M4 (20/28 = 71%). Cytogenetic studies in eight children with FAB M4 and eosinophilia showed normal karyotypes in four patients, inversion 16 in one and other aberrations in three children. Study AML-BFM-78 did not demonstrate any differences in prognosis between patients with and without eosinophilia (event-free survival = EFS after 5 years 37%, SD 8%, vs. 38%, SD 6%). In study AML-BFM-83, however, a clear increase in EFS was seen in children with eosinophilia (EFS 72%, SD 8%, vs. 43%, SD 5%, p = 0.001). This improvement of prognosis mainly concerns patients with FAB M4 and eosinophilia (EFS 81%, SD 10%, vs. 23%, SD 11%, p = 0.006). None of the 12 children in study AML-BFM-83 with FAB M4 and atypical eosinophils has suffered a relapse, two patients belong to the early death group. Multivariate analysis shows only eosinophilia as a favorable prognostic factor in FAB type M4. According to these results FAB type M 4 with eosinophilia is a favorable prognostic parameter in children treated according to the therapy protocol of study AML-BFM-83.

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