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Walter T, Zhenzhen Wang C, Guillaud O, et al. Management of desmoid tumours: A large national database of familial adenomatous patients shows a link to colectomy modalities and low efficacy of medical treatments. United European Gastroenterol J. 2016;5(5):735-741doi: 10.1177/2050640616678150.
Walter, T., Zhenzhen Wang, C., Guillaud, O., Cotte, E., Pasquer, A., Vinet, O., Poncet, G., Ponchon, T., & Saurin, J. C. (2017). Management of desmoid tumours: A large national database of familial adenomatous patients shows a link to colectomy modalities and low efficacy of medical treatments. United European gastroenterology journal, 5(5), 735-741. https://doi.org/10.1177/2050640616678150
Walter, T, et al. "Management of desmoid tumours: A large national database of familial adenomatous patients shows a link to colectomy modalities and low efficacy of medical treatments." United European gastroenterology journal vol. 5,5 (2017): 735-741. doi: https://doi.org/10.1177/2050640616678150
Walter T, Zhenzhen Wang C, Guillaud O, Cotte E, Pasquer A, Vinet O, Poncet G, Ponchon T, Saurin JC. Management of desmoid tumours: A large national database of familial adenomatous patients shows a link to colectomy modalities and low efficacy of medical treatments. United European Gastroenterol J. 2017 Aug;5(5):735-741. doi: 10.1177/2050640616678150. Epub 2016 Oct 28. PMID: 28815038; PMCID: PMC5548349.
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United European Gastroenterol J. 2017 Aug;5(5):735-741. doi: 10.1177/2050640616678150. Epub 2016 Oct 28.

Management of desmoid tumours: A large national database of familial adenomatous patients shows a link to colectomy modalities and low efficacy of medical treatments.

United European gastroenterology journal

T Walter, C Zhenzhen Wang, O Guillaud, E Cotte, A Pasquer, O Vinet, G Poncet, T Ponchon, J-C Saurin

Affiliations

  1. Gastroenterology Department, Edouard Herriot Hospital, Lyon, France.
  2. Ruijin Hospital, Shanghai Jiaotong University, China.
  3. Surgery Department, Lyon Sud Hospital, Lyon, France.
  4. Surgery Department, Edouard Herriot Hospital, Lyon, France.

PMID: 28815038 PMCID: PMC5548349 DOI: 10.1177/2050640616678150

Abstract

BACKGROUND: Desmoid tumours represent a major complication of familial adenomatous polyposis. Our aims were to study the factors associated with the development of desmoid tumours in familial adenomatous polyposis patients, and to describe presentation and management of desmoid tumours.

METHODS AND PATIENTS: We reviewed all patients with familial adenomatous polyposis followed at our institution between 1965-2013, with either identified adenomatous polyposis coli gene mutation, or a personal and family history suggesting adenomatous polyposis coli-related polyposis. Response to treatment of desmoid tumours was assessed by Response Evaluation Criteria In Solid Tumor (RECIST) criteria.

RESULTS: A total of 180 patients with familial adenomatous polyposis were included with a median follow-up of 19 years since diagnosis. Thirty-one (17%) patients developed 58 desmoid tumours, a median (range) 4.7 (0.8-41.6) years after their diagnosis of familial adenomatous polyposis. The only factor significantly associated with occurrence of desmoid tumours was the type of surgery: 12 (12%) desmoid tumours in 104 patients treated by colectomy, versus 19 (25%) desmoid tumours in 76 patients treated by proctocolectomy,

CONCLUSION: If confirmed, colectomy (versus proctocolectomy) should be performed in adenomatous polyposis coli-related familial adenomatous polyposis patients to avoid desmoid tumours. We show that there is a high prevalence of post-surgical recurrence and the low efficacy of available medical treatments for desmoid tumours.

Keywords: Desmoid tumour; familial adenomatous polyposis; risk factor; surgery; treatment

References

  1. Int J Cancer. 2011 Jul 1;129(1):256-61 - PubMed
  2. Br J Surg. 2006 Apr;93(4):407-17 - PubMed
  3. Endoscopy. 2008 Feb;40(2):120-5 - PubMed
  4. Nat Genet. 2002 Feb;30(2):227-32 - PubMed
  5. Br J Surg. 2008 Sep;95(9):1136-9 - PubMed
  6. Surg Oncol Clin N Am. 1996 Jul;5(3):675-88 - PubMed
  7. Clinics (Sao Paulo). 2011;66(10):1839-42 - PubMed
  8. Cancer. 2001 Sep 1;92(5):1259-64 - PubMed
  9. Cancer. 1987 Dec 15;60(12):2863-8 - PubMed
  10. J Clin Oncol. 1998 Sep;16(9):3021-7 - PubMed
  11. Br J Surg. 1970 Aug;57(8):618-31 - PubMed
  12. Indian J Cancer. 2001 Jun-Dec;38(2-4):133-6 - PubMed
  13. Cancer. 2002 Dec 1;95(11):2373-9 - PubMed
  14. Dis Colon Rectum. 2011 Oct;54(10):1229-34 - PubMed
  15. Clin Sarcoma Res. 2016 Apr 04;6:5 - PubMed
  16. Cancer. 2004 Feb 1;100(3):612-20 - PubMed
  17. Ann Oncol. 2014 Sep;25 Suppl 3:iii102-12 - PubMed
  18. Gut. 2004 Dec;53(12):1832-6 - PubMed
  19. Eur J Cancer. 2009 Jan;45(2):228-47 - PubMed
  20. Gut. 1994 Mar;35(3):377-81 - PubMed
  21. Science. 1991 Aug 9;253(5020):665-9 - PubMed
  22. Curr Probl Surg. 1999 Apr;36(4):217-323 - PubMed
  23. J Clin Oncol. 2006 Mar 1;24(7):1195-203 - PubMed
  24. Int J Radiat Oncol Biol Phys. 1998 Dec 1;42(5):1007-14 - PubMed
  25. Cancer. 1991 Sep 15;68(6):1384-8 - PubMed
  26. Br J Surg. 1998 Jul;85(7):970-3 - PubMed
  27. Cancer. 1994 Aug 15;74(4):1270-4 - PubMed
  28. J Gastrointest Surg. 2010 Dec;14(12):1943-9 - PubMed
  29. Br J Surg. 2003 Jul;90(7):890 - PubMed
  30. Clin Gastroenterol Hepatol. 2008 Feb;6(2):215-9 - PubMed
  31. Acta Chir Scand. 1963 Oct;126:305-14 - PubMed
  32. Expert Opin Investig Drugs. 2004 Nov;13(11):1457-68 - PubMed
  33. Am J Surg. 1986 Feb;151(2):230-7 - PubMed
  34. Br J Surg. 2013 Apr;100(5):694-703 - PubMed
  35. Semin Oncol. 1997 Feb;24(1 Suppl 1):S1-65-S1-70 - PubMed
  36. Dis Colon Rectum. 2004 Mar;47(3):334-8; discussion 339-40 - PubMed

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