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Aguinaga M, Sharan C, Singh DN, et al. Chromosomal mapping and nucleotide sequence of a human DNA autonomously replicating sequence. Genomics. 1989;5(3):605-11doi: 10.1016/0888-7543(89)90029-3.
Aguinaga, M., Sharan, C., Singh, D. N., Kegler, D., Siddiqui, K. A., & Valenzuela, M. S. (1989). Chromosomal mapping and nucleotide sequence of a human DNA autonomously replicating sequence. Genomics, 5(3), 605-11. https://doi.org/10.1016/0888-7543(89)90029-3
Aguinaga, M, et al. "Chromosomal mapping and nucleotide sequence of a human DNA autonomously replicating sequence." Genomics vol. 5,3 (1989): 605-11. doi: https://doi.org/10.1016/0888-7543(89)90029-3
Aguinaga M, Sharan C, Singh DN, Kegler D, Siddiqui KA, Valenzuela MS. Chromosomal mapping and nucleotide sequence of a human DNA autonomously replicating sequence. Genomics. 1989 Oct;5(3):605-11. doi: 10.1016/0888-7543(89)90029-3. PMID: 2613242.
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Genomics. 1989 Oct;5(3):605-11. doi: 10.1016/0888-7543(89)90029-3.

Chromosomal mapping and nucleotide sequence of a human DNA autonomously replicating sequence.

Genomics

M Aguinaga, C Sharan, D N Singh, D Kegler, K A Siddiqui, M S Valenzuela

Affiliations

  1. Division of Biomedical Sciences, Meharry Medical College, Nashville, Tennessee 37208.

PMID: 2613242 DOI: 10.1016/0888-7543(89)90029-3

Abstract

A 1.1-kb human DNA fragment (ARSH1) capable of functioning as a putative origin of replication in yeast cells has been characterized both by in situ hybridization to human metaphase chromosomes and by DNA sequencing. Our hybridization studies show a preferential localization of ARSH1 in chromosome regions 1p34-36 and 2q34-37. DNA sequence analysis indicates that in addition to the consensus sequence required for ARS function in yeast cells, nuclear matrix-associated DNA motifs are also present in the 1.1-kb fragment. These results suggest that ARSH1 sequences may serve as points of anchorage to the nuclear matrix for chromosomes 1 and 2.

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