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Parker RC, Mardon G, Lebo RV, et al. Isolation of duplicated human c-src genes located on chromosomes 1 and 20. Mol Cell Biol. 1985;5(4):831-8doi: 10.1128/mcb.5.4.831-838.1985.
Parker, R. C., Mardon, G., Lebo, R. V., Varmus, H. E., & Bishop, J. M. (1985). Isolation of duplicated human c-src genes located on chromosomes 1 and 20. Molecular and cellular biology, 5(4), 831-8. https://doi.org/10.1128/mcb.5.4.831-838.1985
Parker, R C, et al. "Isolation of duplicated human c-src genes located on chromosomes 1 and 20." Molecular and cellular biology vol. 5,4 (1985): 831-8. doi: https://doi.org/10.1128/mcb.5.4.831-838.1985
Parker RC, Mardon G, Lebo RV, Varmus HE, Bishop JM. Isolation of duplicated human c-src genes located on chromosomes 1 and 20. Mol Cell Biol. 1985 Apr;5(4):831-8. doi: 10.1128/mcb.5.4.831-838.1985. PMID: 2581127; PMCID: PMC366788.
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Atypon Free PMC Article

Mol Cell Biol. 1985 Apr;5(4):831-8. doi: 10.1128/mcb.5.4.831-838.1985.

Isolation of duplicated human c-src genes located on chromosomes 1 and 20.

Molecular and cellular biology

R C Parker, G Mardon, R V Lebo, H E Varmus, J M Bishop

PMID: 2581127 PMCID: PMC366788 DOI: 10.1128/mcb.5.4.831-838.1985
Free PMC Article

Abstract

The oncogene (v-src) of Rous sarcoma virus apparently arose by transduction of the chicken gene known as c-src(chicken). We isolated DNA fragments representative of two src-related loci from recombinant DNA bacteriophage libraries of the human genome. One of these loci, c-src1(human), appeared to direct the synthesis of a 5-kilobase polyadenylated RNA that presumably encodes pp60c-src(human). Probes specific for the other locus, c-src2(human), did not hybridize to polyadenylated RNA prepared from a variety of human cell lines. Partial nucleotide sequence determinations of the loci demonstrated that c-src1(human) is highly related to chicken c-src and that c-src2(human) is slightly more divergent. The sequences imply that the final two coding exons of each human locus are identical in length to those of chicken c-src and that the location of an amber stop codon is unchanged in all three loci. c-src1(human) has been mapped to chromosome 20, and the second locus is located on chromosome 1. We conclude that c-src1(human) is the analog of c-src(chicken) and that the duplicated locus, c-src2(human), may also be expressed.

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