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Trejdosiewicz LK, Badr-el-Din S, Smart CJ, et al. Colonic mucosal T lymphocytes in ulcerative colitis: expression of CD7 antigen in relation to MHC class II (HLA-D) antigens. Dig Dis Sci. 1989;34(9):1449-56doi: 10.1007/BF01538084.
Trejdosiewicz, L. K., Badr-el-Din, S., Smart, C. J., Malizia, G., Oakes, D. J., Heatley, R. V., & Losowsky, M. S. (1989). Colonic mucosal T lymphocytes in ulcerative colitis: expression of CD7 antigen in relation to MHC class II (HLA-D) antigens. Digestive diseases and sciences, 34(9), 1449-56. https://doi.org/10.1007/BF01538084
Trejdosiewicz, L K, et al. "Colonic mucosal T lymphocytes in ulcerative colitis: expression of CD7 antigen in relation to MHC class II (HLA-D) antigens." Digestive diseases and sciences vol. 34,9 (1989): 1449-56. doi: https://doi.org/10.1007/BF01538084
Trejdosiewicz LK, Badr-el-Din S, Smart CJ, Malizia G, Oakes DJ, Heatley RV, Losowsky MS. Colonic mucosal T lymphocytes in ulcerative colitis: expression of CD7 antigen in relation to MHC class II (HLA-D) antigens. Dig Dis Sci. 1989 Sep;34(9):1449-56. doi: 10.1007/BF01538084. PMID: 2670488.
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Dig Dis Sci. 1989 Sep;34(9):1449-56. doi: 10.1007/BF01538084.

Colonic mucosal T lymphocytes in ulcerative colitis: expression of CD7 antigen in relation to MHC class II (HLA-D) antigens.

Digestive diseases and sciences

L K Trejdosiewicz, S Badr-el-Din, C J Smart, G Malizia, D J Oakes, R V Heatley, M S Losowsky

Affiliations

  1. Department of Medicine, University of Leeds, St. James' Hospital, U.K.

PMID: 2670488 DOI: 10.1007/BF01538084

Abstract

T-cell subsets and their activation state were examined by double-label immunofluorescence of cryostat tissue sections of the colon from 21 patients with ulcerative colitis (UC) and 30 histologically normal controls. Expression of MHC class I (HLA-A, B, C) and class II (HLA-D) antigens was studied in parallel. In the normal colonic mucosa, the CD4:CD8 ratio in the epithelial compartment approximated 1:1, and in the lamina propria, 2.55:1. Of the CD8+ (cytotoxic/suppressor) subset, approximately half did not express the CD5 "pan-T" marker in either compartment. Virtually no Leu8+ cells were observed, implying that the CD4+ subset consisted of helper, rather than suppressor-inducer cells. Classical markers of T-cell activation (CD25, HLA-D) and proliferation were absent, and strong expression of the CD7 "immunostimulation" marker was approximately equal in both CD4 and CD8 subsets. The epithelium was uniformly negative for class II antigens, but positive for class I. In UC, there were no significant alterations in CD4:CD8 ratios in either compartment, and there were no changes with respect to phenotype of the subsets. In 11 of 19 patients (mainly with total colitis), enterocytes were HLA-D+. In this HLA-D+ group, there was an increase in the percentage of CD4+ cells coexpressing CD7; this difference was significant (P less than 0.02) in the lamina propria. Increased expression of CD7 was also found by the CD6+ T cell subset (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

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References

  1. Ann N Y Acad Sci. 1983 Jun 30;409:498-509 - PubMed
  2. Immunology. 1989 Jan;66(1):90-5 - PubMed
  3. Clin Exp Immunol. 1983 Sep;53(3):614-8 - PubMed
  4. Nature. 1988 Sep 15;335(6187):208-10 - PubMed
  5. Clin Exp Immunol. 1988 Jul;73(1):63-9 - PubMed
  6. Gastroenterology. 1986 Aug;91(2):379-85 - PubMed
  7. Clin Exp Immunol. 1981 Jun;44(3):453-8 - PubMed
  8. J Immunol. 1984 May;132(5):2244-52 - PubMed
  9. J Immunol. 1982 Nov;129(5):1997-2000 - PubMed
  10. Interferon. 1986;7:47-87 - PubMed
  11. Gut. 1986 Feb;27(2):153-7 - PubMed
  12. J Immunol. 1988 Nov 1;141(9):3029-36 - PubMed
  13. J Clin Pathol. 1987 Mar;40(3):312-7 - PubMed
  14. Clin Exp Immunol. 1985 May;60(2):437-46 - PubMed
  15. Scand J Gastroenterol Suppl. 1985;114:17-38 - PubMed
  16. Adv Exp Med Biol. 1987;216A:465-73 - PubMed
  17. J Exp Med. 1987 Nov 1;166(5):1471-83 - PubMed
  18. Gut. 1987 Aug;28(8):1013-21 - PubMed
  19. Immunology. 1986 May;58(1):9-14 - PubMed
  20. Immunol Today. 1986 Jan;7(1):6 - PubMed
  21. Immunology. 1986 May;58(1):1-7 - PubMed
  22. Gut. 1988 Aug;29(8):1070-5 - PubMed
  23. Nature. 1984 Dec 13-19;312(5995):639-41 - PubMed
  24. Clin Exp Immunol. 1984 Apr;56(1):159-66 - PubMed

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