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Fosså SD, Kullmann G, Lien HH, et al. Chemotherapy of advanced seminoma: clinical significance of radiological findings before and after treatment. Br J Urol. 1989;64(5):530-4doi: 10.1111/j.1464-410x.1989.tb05293.x.
Fosså, S. D., Kullmann, G., Lien, H. H., Stenwig, A. E., & Ous, S. (1989). Chemotherapy of advanced seminoma: clinical significance of radiological findings before and after treatment. British journal of urology, 64(5), 530-4. https://doi.org/10.1111/j.1464-410x.1989.tb05293.x
Fosså, S D, et al. "Chemotherapy of advanced seminoma: clinical significance of radiological findings before and after treatment." British journal of urology vol. 64,5 (1989): 530-4. doi: https://doi.org/10.1111/j.1464-410x.1989.tb05293.x
Fosså SD, Kullmann G, Lien HH, Stenwig AE, Ous S. Chemotherapy of advanced seminoma: clinical significance of radiological findings before and after treatment. Br J Urol. 1989 Nov;64(5):530-4. doi: 10.1111/j.1464-410x.1989.tb05293.x. PMID: 2611626.
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Br J Urol. 1989 Nov;64(5):530-4. doi: 10.1111/j.1464-410x.1989.tb05293.x.

Chemotherapy of advanced seminoma: clinical significance of radiological findings before and after treatment.

British journal of urology

S D Fosså, G Kullmann, H H Lien, A E Stenwig, S Ous

Affiliations

  1. Department of Medical Oncology, Norwegian Radium Hospital, Oslo, Norway.

PMID: 2611626 DOI: 10.1111/j.1464-410x.1989.tb05293.x

Abstract

The predictive significance of the mass detected following chemotherapy was assessed in 46 patients with advanced seminoma. Patients with residual viable seminoma in the post-chemotherapy operation specimen or who developed recurrent disease were regarded as chemotherapy failures. This group included 1 of 20 patients in whom the retroperitoneal masses were less than or equal to 10 cm2 3 to 4 weeks after chemotherapy and 4 of 15 patients whose residual masses were greater than 10 cm2. Four of 11 patients with mediastinal tumours achieved a complete remission (mediastinal masses less than or equal to 1 cm2). However, 2 of these 4 patients relapsed, as did 2 of the 4 who achieved a partial remission. In no case was the original size of the tumour significantly related to treatment failure. Three patients had residual lung masses; 1 of these contained histological evidence of viable tumour. In one-third of the irradiated relapse-free patients, slightly enlarged masses were visible on follow-up computed tomography scans taken several years after treatment, even in patients without tumour activity. There is a 25% risk of relapse in patients with advanced seminoma who have retroperitoneal masses greater than 10 cm2 following cisplatin-based chemotherapy. They should be followed up regularly for many years.

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