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Lindemann F, Plange N, Kuerten D, et al. Three-Year Follow-Up of Trabeculectomy with 5-Fluorouracil. Ophthalmic Res. 2017;58(2):74-80doi: 10.1159/000464446.
Lindemann, F., Plange, N., Kuerten, D., Schimitzek, H., & Koutsonas, A. (2017). Three-Year Follow-Up of Trabeculectomy with 5-Fluorouracil. Ophthalmic research, 58(2), 74-80. https://doi.org/10.1159/000464446
Lindemann, Friederike, et al. "Three-Year Follow-Up of Trabeculectomy with 5-Fluorouracil." Ophthalmic research vol. 58,2 (2017): 74-80. doi: https://doi.org/10.1159/000464446
Lindemann F, Plange N, Kuerten D, Schimitzek H, Koutsonas A. Three-Year Follow-Up of Trabeculectomy with 5-Fluorouracil. Ophthalmic Res. 2017;58(2):74-80. doi: 10.1159/000464446. Epub 2017 Apr 28. PMID: 28449000.
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Ophthalmic Res. 2017;58(2):74-80. doi: 10.1159/000464446. Epub 2017 Apr 28.

Three-Year Follow-Up of Trabeculectomy with 5-Fluorouracil.

Ophthalmic research

Friederike Lindemann, Niklas Plange, David Kuerten, Hannah Schimitzek, Antonis Koutsonas

Affiliations

  1. Department of Ophthalmology, RWTH Aachen University, Aachen, Germany.

PMID: 28449000 DOI: 10.1159/000464446

Abstract

PURPOSE: To evaluate the long-term outcome of trabeculectomy with intra- and postoperative 5-fluorouracil (5-FU) application in glaucoma.

METHODS: Eighty-six patients with glaucoma planned for primary trabeculectomy with 5-FU and a minimum follow-up of 3 years were retrospectively analyzed. Success rates, postsurgical 5-FU injections, needling procedures, and complications were analyzed.

RESULTS: Mean intraocular pressure (IOP) decreased from 27.2 ± 6.7 to 13.2 ± 4.2 mm Hg at 1 year and 13.8 ± 3.7 mm Hg at the 3-year follow-up. The complete success rates (no IOP-lowering medication) were 83, 79, 73, and 45% at 1 year for IOP ≤21, ≤18, ≤16, and ≤12 mm Hg, respectively, and 64, 59, 56, and 20% for these criteria at 3 years. The average number of medications decreased from preoperatively 2.9 ± 1.4 to 0.2 ± 0.5 at 1 year and 0.7 ± 1.1 at 3 years. During the first 6 months, subconjunctival 5-FU injections were performed in 49 cases. Eleven patients underwent bleb needling during the first 6 months and 13 patients underwent the procedure between the 6th month and the 3rd year. Malignant glaucoma and bleb-related endophthalmitis occurred in 1 patient each.

CONCLUSIONS: Trabeculectomy with 5-FU is an efficient surgical procedure for glaucoma treatment when combined with intensified postsurgical care.

© 2017 S. Karger AG, Basel.

Keywords: 5-Fluorouracil; Antifibrotics; Long-term results; Trabeculectomy

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