Display options
Cite
Cui J, Boehmer J, Blaha C, et al. Muscle sympathetic nerve activity response to heat stress is attenuated in chronic heart failure patients. Am J Physiol Regul Integr Comp Physiol. 2017;312(6):R873-R882doi: 10.1152/ajpregu.00355.2016.
Cui, J., Boehmer, J., Blaha, C., & Sinoway, L. I. (2017). Muscle sympathetic nerve activity response to heat stress is attenuated in chronic heart failure patients. American journal of physiology. Regulatory, integrative and comparative physiology, 312(6), R873-R882. https://doi.org/10.1152/ajpregu.00355.2016
Cui, Jian, et al. "Muscle sympathetic nerve activity response to heat stress is attenuated in chronic heart failure patients." American journal of physiology. Regulatory, integrative and comparative physiology vol. 312,6 (2017): R873-R882. doi: https://doi.org/10.1152/ajpregu.00355.2016
Cui J, Boehmer J, Blaha C, Sinoway LI. Muscle sympathetic nerve activity response to heat stress is attenuated in chronic heart failure patients. Am J Physiol Regul Integr Comp Physiol. 2017 Jun 01;312(6):R873-R882. doi: 10.1152/ajpregu.00355.2016. Epub 2017 Mar 22. PMID: 28330967; PMCID: PMC5495922.
Copy Download .nbib Format: NLM
Share it on

Am J Physiol Regul Integr Comp Physiol. 2017 Jun 01;312(6):R873-R882. doi: 10.1152/ajpregu.00355.2016. Epub 2017 Mar 22.

Muscle sympathetic nerve activity response to heat stress is attenuated in chronic heart failure patients.

American journal of physiology. Regulatory, integrative and comparative physiology

Jian Cui, John Boehmer, Cheryl Blaha, Lawrence I Sinoway

Affiliations

  1. Penn State Heart and Vascular Institute, Penn State Hershey, Milton S. Hershey Medical Center, Hershey, Pennsylvania.
  2. Penn State Heart and Vascular Institute, Penn State Hershey, Milton S. Hershey Medical Center, Hershey, Pennsylvania [email protected].

PMID: 28330967 PMCID: PMC5495922 DOI: 10.1152/ajpregu.00355.2016

Abstract

Heat stress evokes significant increases in muscle sympathetic nerve activity (MSNA) in healthy individuals. The MSNA response to heat stress in chronic heart failure (CHF) is unknown. We hypothesized that the MSNA response to heat stress is attenuated in CHF. Passive whole body heating was applied with water-perfused suits in 13 patients (61 ± 2 yr) with stable class II-III CHF, 12 age-matched (62 ± 2 yr) healthy subjects, and 14 young (24 ± 1 yr) healthy subjects. Mild heating (i.e., increases in skin temperature ΔTsk ~2-4°C, internal temperature ΔTcore <0.3°C) significantly decreased MSNA in CHF patients; however, it did not significantly alter the MSNA in the age-matched and young healthy subjects. Heat stress (i.e., ΔTsk ~4°C and ΔTcore ~0.6°C) raised MSNA in the age-matched (32.9 ± 3.2 to 45.6 ± 4.2 bursts/min;

Copyright © 2017 the American Physiological Society.

Keywords: heart failure; hemodynamics; nervous system; stress; sympathetic

References

  1. Circulation. 1986 May;73(5):913-9 - PubMed
  2. J Appl Physiol. 1970 Apr;28(4):415-20 - PubMed
  3. Circ Heart Fail. 2013 Mar;6(2):271-8 - PubMed
  4. Physiol Rep. 2015 Aug;3(8):null - PubMed
  5. Med Sci Sports Exerc. 2008 Nov;40(11):1932-8 - PubMed
  6. Int J Cardiol. 2009 Jul 10;135(3):302-7 - PubMed
  7. Eur Heart J. 2006 Feb;27(3):338-43 - PubMed
  8. J Physiol. 2006 Oct 15;576(Pt 2):625-34 - PubMed
  9. Hypertension. 2001 Dec 1;38(6):1377-81 - PubMed
  10. Acta Physiol Scand. 2003 Mar;177(3):391-8 - PubMed
  11. Am J Physiol Regul Integr Comp Physiol. 2002 Nov;283(5):R1221-6 - PubMed
  12. Am J Physiol Heart Circ Physiol. 2001 Jun;280(6):H2868-75 - PubMed
  13. Circulation. 1995 May 15;91(10):2582-90 - PubMed
  14. Circulation. 1997 Jan 21;95(2):316-9 - PubMed
  15. J Appl Physiol. 1971 Dec;31(6):864-9 - PubMed
  16. Circulation. 2004 Nov 2;110(18):2786-91 - PubMed
  17. J Appl Physiol. 1975 Jan;38(1):58-63 - PubMed
  18. Circulation. 2001 Oct 30;104(18):2194-9 - PubMed
  19. J Appl Physiol (1985). 1987 Sep;63(3):930-6 - PubMed
  20. Am J Physiol. 1994 Sep;267(3 Pt 2):H994-1001 - PubMed
  21. Am J Physiol Heart Circ Physiol. 2006 Jul;291(1):H482-3 - PubMed
  22. Physiol Rev. 1979 Oct;59(4):919-57 - PubMed
  23. Circulation. 1995 Dec 1;92(11):3206-11 - PubMed
  24. J Physiol. 2006 Jun 1;573(Pt 2):445-51 - PubMed
  25. J Appl Physiol (1985). 2003 Dec;95(6):2598-603 - PubMed
  26. Acta Physiol Scand. 1991 Jun;142(2):201-9 - PubMed
  27. J Physiol. 2015 May 1;593(9):2225-35 - PubMed
  28. Clin Cardiol. 1995 Mar;18(3 Suppl I):I3-8 - PubMed
  29. N Engl J Med. 1996 Jul 11;335(2):84-90 - PubMed
  30. Clin Auton Res. 1993 Jun;3(3):201-5 - PubMed
  31. Am J Cardiol. 1992 Feb 15;69(5):523-31 - PubMed
  32. J Appl Physiol (1985). 1985 Feb;58(2):400-8 - PubMed
  33. Circulation. 1988 Apr;77(4):721-30 - PubMed
  34. Acta Physiol (Oxf). 2007 Aug;190(4):265-75 - PubMed
  35. J Appl Physiol (1985). 2011 Nov;111(5):1329-34 - PubMed
  36. J Appl Physiol (1985). 2010 Dec;109(6):1880-6 - PubMed
  37. Am J Med Sci. 1961 Oct;242:468-74 - PubMed
  38. Am J Prev Med. 1999 May;16(4):269-77 - PubMed
  39. J Physiol. 2001 Mar 15;531(Pt 3):861-9 - PubMed
  40. Circulation. 1999 Jul 20;100(3):280-6 - PubMed
  41. J Am Coll Cardiol. 2002 Mar 6;39(5):754-9 - PubMed
  42. Circulation. 2005 Oct 11;112(15):2286-92 - PubMed
  43. Circulation. 1986 Apr;73(4):615-21 - PubMed
  44. J Am Coll Cardiol. 2002 Mar 6;39(5):760-6 - PubMed
  45. N Engl J Med. 1984 Sep 27;311(13):819-23 - PubMed
  46. Circulation. 1991 Nov;84(5):2034-9 - PubMed
  47. Am J Physiol. 1999 Dec;277(6 Pt 2):H2348-52 - PubMed
  48. Hypertension. 1990 May;15(5):505-7 - PubMed

MeSH terms

Publication Types

Grant support