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Lee MG, Hanchard B, Williams NP. Drug-induced acute liver disease. Postgrad Med J. 1989;65(764):367-70doi: 10.1136/pgmj.65.764.367.
Lee, M. G., Hanchard, B., & Williams, N. P. (1989). Drug-induced acute liver disease. Postgraduate medical journal, 65(764), 367-70. https://doi.org/10.1136/pgmj.65.764.367
Lee, M G, et al. "Drug-induced acute liver disease." Postgraduate medical journal vol. 65,764 (1989): 367-70. doi: https://doi.org/10.1136/pgmj.65.764.367
Lee MG, Hanchard B, Williams NP. Drug-induced acute liver disease. Postgrad Med J. 1989 Jun;65(764):367-70. doi: 10.1136/pgmj.65.764.367. PMID: 2608576; PMCID: PMC2429339.
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Postgrad Med J. 1989 Jun;65(764):367-70. doi: 10.1136/pgmj.65.764.367.

Drug-induced acute liver disease.

Postgraduate medical journal

M G Lee, B Hanchard, N P Williams

Affiliations

  1. Department of Medicine, University Hospital, University of the West Indies, Kingston, Jamaica.

PMID: 2608576 PMCID: PMC2429339 DOI: 10.1136/pgmj.65.764.367
Free PMC Article

Abstract

Fifty-three patients with drug-induced acute liver disease are reported. There were 35 females and 18 males with a mean age of 41 years. All but one patient had jaundice or hyperbilirubinaemia and 51 had abnormal liver enzymes. Histologically 38 patients (72%) had cholestatic injury while 15 had cytotoxic parenchymal damage. Methyldopa, chlorpropamide, chlorpromazine, halothane and the contraceptive pill accounted for 60% of cases. Fifty-one patients recovered after drug withdrawal while 2 died of hepatic failure. Drug-induced liver injury must be considered in patients presenting with evidence of hepatic disease as the majority will recover on withdrawal.

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