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Molecules. 2017 Jan 27;22(2). doi: 10.3390/molecules22020206.

Hyperuricaemia, Xanthine Oxidoreductase and Ribosome-Inactivating Proteins from Plants: The Contributions of Fiorenzo Stirpe to Frontline Research.

Molecules (Basel, Switzerland)

Andrea Bolognesi, Massimo Bortolotti, Maria Giulia Battelli, Letizia Polito

Affiliations

  1. Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy. [email protected].
  2. Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy. [email protected].
  3. Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy. [email protected].
  4. Department of Experimental, Diagnostic and Specialty Medicine-DIMES, Alma Mater Studiorum, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy. [email protected].

PMID: 28134797 PMCID: PMC6155646 DOI: 10.3390/molecules22020206

Abstract

The enzymes called ribosome-inactivating proteins (RIPs) that are able to depurinate  nucleic acids and arrest vital cellular functions, including protein synthesis, are still a frontline  research field, mostly because of their promising medical applications. The contributions of Stirpe  to the development of these studies has been one of the most relevant. After a short biographical  introduction, an overview is offered of the main results obtained by his investigations during last  55 years on his main research lines: hyperuricaemia, xanthine oxidoreductase and RIPs.

Keywords: gout;   xanthine oxidoreductase;  hyperuricaemia;  immunotoxins;  ribosome‐inactivating proteins;  ricin;  toxic lectins

References

  1. J Biol Chem. 1969 Jul 25;244(14):3855-63 - PubMed
  2. Bone Marrow Transplant. 1991;7 Suppl 2:30 - PubMed
  3. Eur J Biochem. 1988 Oct 1;176(3):581-8 - PubMed
  4. Virchows Arch B Cell Pathol Incl Mol Pathol. 1987;53(5):259-71 - PubMed
  5. Cancer Immunol Immunother. 1988;26(3):231-6 - PubMed
  6. Biochim Biophys Acta. 1969 Sep 30;191(1):164-6 - PubMed
  7. Clin Chim Acta. 1999 Mar;281(1-2):147-58 - PubMed
  8. Hepatology. 1994 Oct;20(4 Pt 1):940-7 - PubMed
  9. J Biol Regul Homeost Agents. 1995 Apr-Jun;9(2):55-62 - PubMed
  10. J Biol Regul Homeost Agents. 2005 Jul-Dec;19(3-4):145-52 - PubMed
  11. Biochem J. 1981 May 1;195(2):399-405 - PubMed
  12. Biochem J. 1997 Jun 15;324 ( Pt 3):963-70 - PubMed
  13. Virchows Arch B Cell Pathol Incl Mol Pathol. 1979 May 4;30(1):15-24 - PubMed
  14. Arch Biochem Biophys. 1973 Apr;155(2):278-89 - PubMed
  15. Biochem J. 1972 Feb;126(3):747-9 - PubMed
  16. Biochem J. 1983 Dec 1;215(3):433-9 - PubMed
  17. Biochem J. 1973 Nov;136(3):813-5 - PubMed
  18. Planta. 1999 Mar;208(1):125-31 - PubMed
  19. FEBS Lett. 1977 Dec 20;85(1):65-7 - PubMed
  20. J Biol Chem. 1980 Jul 25;255(14):6947-53 - PubMed
  21. J Natl Cancer Inst. 1985 Jul;75(1):151-9 - PubMed
  22. Br J Cancer. 1997;75(6):822-8 - PubMed
  23. Toxicon. 2007 Jul;50(1):94-105 - PubMed
  24. Arch Virol. 1982;71(4):323-32 - PubMed
  25. Cancer Immunol Immunother. 1996 Jul;42(6):319-28 - PubMed
  26. Clin Exp Immunol. 2004 Feb;135(2):259-66 - PubMed
  27. Haematologica. 1999 Nov;84(11):988-95 - PubMed
  28. Immunol Rev. 1982;62:185-216 - PubMed
  29. Eur J Biochem. 1981 Jun 1;116(3):447-54 - PubMed
  30. Biochim Biophys Acta. 1993 Oct 19;1216(1):31-42 - PubMed
  31. Br J Haematol. 2000 Aug;110(2):351-61 - PubMed
  32. Toxicon. 2005 Nov;46(6):658-63 - PubMed
  33. Biochem J. 1976 Apr 15;156(1):1-6 - PubMed
  34. Eur J Haematol Suppl. 1989;51:176-81 - PubMed
  35. Cell Mol Life Sci. 2006 Aug;63(16):1850-66 - PubMed
  36. Rheumatology (Oxford). 2013 Mar;52(3):421-6 - PubMed
  37. Neurotoxicology. 2007 May;28(3):637-44 - PubMed
  38. FEBS Lett. 1996 Nov 4;396(2-3):132-4 - PubMed
  39. J Immunol. 1988 Nov 15;141(10):3662-70 - PubMed
  40. Adv Chronic Kidney Dis. 2012 Nov;19(6):392-7 - PubMed
  41. J Biol Regul Homeost Agents. 2005 Jul-Dec;19(3-4):120-9 - PubMed
  42. Br J Cancer. 1988 Nov;58(5):558-61 - PubMed
  43. Br J Cancer. 1992 Sep;66(3):427-32 - PubMed
  44. J Exp Med. 1987 Jul 1;166(1):43-62 - PubMed
  45. Bone Marrow Transplant. 1990 Jul;6(1):31-6 - PubMed
  46. Br J Haematol. 1992 Jun;81(2):203-11 - PubMed
  47. Br J Cancer. 1989 Sep;60(3):315-9 - PubMed
  48. Cancer Immunol Immunother. 1993 May;36(5):346-50 - PubMed
  49. Neuropathol Appl Neurobiol. 1987 Jan-Feb;13(1):39-53 - PubMed
  50. Biochem J. 1978 Nov 15;176(2):371-9 - PubMed
  51. Br J Haematol. 1996 Mar;92(4):872-9 - PubMed
  52. Biochem J. 1979 Aug 15;182(2):633-5 - PubMed
  53. J Biol Chem. 2002 Apr 19;277(16):13709-16 - PubMed
  54. Br J Cancer. 1995 May;71(5):986-94 - PubMed
  55. Xenobiotica. 1990 Dec;20(12):1331-41 - PubMed
  56. Lancet. 1992 May 16;339(8803):1195-6 - PubMed
  57. Nature. 1970 Jul 18;227(5255):292-3 - PubMed
  58. Biochem J. 1973 Feb;131(2):191-8 - PubMed
  59. Brain Res. 1988 Jan 12;438(1-2):145-54 - PubMed
  60. Biochem J. 1980 Jan 1;185(1):203-10 - PubMed
  61. Nature. 1994 Dec 15;372(6507):624 - PubMed
  62. Biochem J. 1967 Feb;102(2):520-4 - PubMed
  63. Int J Cancer. 1996 Feb 8;65(4):485-90 - PubMed
  64. Cancer Immunol Immunother. 1995 Feb;40(2):109-14 - PubMed
  65. Planta. 1997 Dec;203(4):422-9 - PubMed
  66. Biochim Biophys Acta. 2006 May;1760(5):783-92 - PubMed
  67. Transplantation. 1992 Aug;54(2):351-6 - PubMed
  68. Biochem J. 1980 Sep 15;190(3):843-5 - PubMed
  69. J Biol Chem. 1987 Jun 15;262(17):8128-30 - PubMed
  70. Biochem J. 1982 Dec 1;207(3):505-9 - PubMed
  71. Eur J Biochem. 1995 Mar 15;228(3):935-40 - PubMed
  72. J Biol Chem. 1985 Nov 25;260(27):14589-95 - PubMed
  73. Am J Gastroenterol. 2002 Aug;97(8):2079-85 - PubMed
  74. J Immunol. 2001 Oct 15;167(8):4222-9 - PubMed
  75. Virchows Arch. 1996 Feb;427(5):529-35 - PubMed
  76. Bull NYU Hosp Jt Dis. 2008;66(3):231-9 - PubMed
  77. Br J Cancer. 1993 Jun;67(6):1248-53 - PubMed
  78. Bone Marrow Transplant. 1994 Apr;13(4):465-71 - PubMed
  79. Biochem J. 1986 Dec 15;240(3):659-65 - PubMed
  80. Biochem J. 1965 Feb;94:309-13 - PubMed
  81. Am J Gastroenterol. 2001 Apr;96(4):1194-9 - PubMed
  82. Int J Cancer. 1996 Nov 4;68(3):349-55 - PubMed
  83. Eur J Neurosci. 1993 Oct 1;5(10):1292-301 - PubMed
  84. Clin Exp Immunol. 1992 Sep;89(3):341-6 - PubMed
  85. Brain Res. 1990 Dec 24;537(1-2):279-86 - PubMed
  86. J Natl Cancer Inst. 1978 Sep;61(3):657-76 - PubMed
  87. Biochem J. 1972 Feb;126(3):739-45 - PubMed
  88. Scand J Immunol. 1989 Sep;30(3):369-72 - PubMed
  89. Biochim Biophys Acta. 1990 Nov 30;1087(3):293-302 - PubMed
  90. Biochem J. 1982 Apr 1;203(1):55-9 - PubMed
  91. Biochem J. 1982 Jan 15;202(1):279-80 - PubMed
  92. Biochim Biophys Acta. 1970 Jul 15;212(1):195-7 - PubMed
  93. Lancet. 1970 Dec 19;2(7686):1310-1 - PubMed
  94. J Drug Target. 1998;5(3):181-91 - PubMed
  95. Biochem J. 1996 Oct 15;319 ( Pt 2):507-13 - PubMed
  96. Eur J Haematol. 1989 Mar;42(3):238-45 - PubMed
  97. Molecules. 2016 Nov 26;21(12): - PubMed
  98. Biochem J. 1983 Dec 15;216(3):617-25 - PubMed
  99. Biochim Biophys Acta. 1993 Dec 21;1154(3-4):237-82 - PubMed
  100. Leukemia. 2004 Jul;18(7):1215-22 - PubMed
  101. FEBS Lett. 1972 Feb 15;20(3):327-329 - PubMed
  102. Curr Eye Res. 2002 Jan;24(1):58-65 - PubMed
  103. Biochem J. 1978 Aug 15;174(2):491-6 - PubMed
  104. Biochemistry. 1973 Jul 31;12(16):3121-6 - PubMed
  105. Brain Res. 1995 Aug 21;689(2):163-71 - PubMed
  106. Biochim Biophys Acta. 1979 May 24;562(3):495-503 - PubMed
  107. Transplant Proc. 2001 Feb-Mar;33(1-2):285-7 - PubMed
  108. J Drug Target. 2000;8(5):281-8 - PubMed
  109. Eur J Biochem. 1973 May;35(1):179-85 - PubMed
  110. Clin Exp Immunol. 1988 Jul;73(1):128-33 - PubMed
  111. Biochim Biophys Acta. 1989 Dec 8;993(2-3):287-92 - PubMed
  112. Biochim Biophys Acta. 1993 Oct 19;1216(1):43-9 - PubMed
  113. FEBS Lett. 1977 Apr 15;76(2):173-6 - PubMed
  114. Blood. 2003 Jan 1;101(1):202-9 - PubMed
  115. Eur J Haematol Suppl. 1989;51:173-5 - PubMed
  116. Virchows Arch B Cell Pathol. 1976 Feb 11;20(1):15-28 - PubMed
  117. Cancer Res. 1990 Jul 15;50(14):4291-4 - PubMed
  118. Biochem J. 1980 Feb 15;186(2):439-41 - PubMed
  119. Biochem J. 1968 Jun;108(2):349-51 - PubMed
  120. Experientia. 1979 Aug 15;35(8):1086-7 - PubMed
  121. FEBS Lett. 1997 May 26;408(3):355-9 - PubMed
  122. Int J Cancer. 1991 Apr 1;47(6):909-15 - PubMed
  123. Blood. 1995 Apr 15;85(8):2139-46 - PubMed
  124. Br J Haematol. 1998 Apr;101(1):179-88 - PubMed
  125. Int J Pept Protein Res. 1988 Mar;31(3):265-8 - PubMed
  126. APMIS. 1990 Jul;98(7):585-93 - PubMed
  127. Cancer Immunol Immunother. 1992;35(6):421-5 - PubMed
  128. FEBS Lett. 1968 Dec;2(2):83-84 - PubMed
  129. Molecules. 2016 Nov 18;21(11): - PubMed
  130. Br J Haematol. 1994 Jan;86(1):97-105 - PubMed
  131. FEBS Lett. 1983 Jun 27;157(1):150-4 - PubMed
  132. J Hematother. 1995 Oct;4(5):429-32 - PubMed
  133. Mol Microbiol. 1998 Jul;29(2):661-2 - PubMed
  134. Neurochem Res. 1979 Apr;4(2):259-68 - PubMed
  135. Biochem J. 1989 Feb 1;257(3):801-7 - PubMed
  136. Br J Haematol. 1995 Jul;90(3):572-7 - PubMed
  137. Transplantation. 1989 Jul;48(1):119-22 - PubMed
  138. Biochem J. 1973 Nov;136(3):677-83 - PubMed

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