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Murphy CA, Konarska M, McCarty R. Sympathetic-adrenal medullary responses to acute stress in Dahl hypertensive (S/JR) rats. Physiol Behav. 1989;45(1):27-31doi: 10.1016/0031-9384(89)90162-5.
Murphy, C. A., Konarska, M., & McCarty, R. (1989). Sympathetic-adrenal medullary responses to acute stress in Dahl hypertensive (S/JR) rats. Physiology & behavior, 45(1), 27-31. https://doi.org/10.1016/0031-9384(89)90162-5
Murphy, C A, et al. "Sympathetic-adrenal medullary responses to acute stress in Dahl hypertensive (S/JR) rats." Physiology & behavior vol. 45,1 (1989): 27-31. doi: https://doi.org/10.1016/0031-9384(89)90162-5
Murphy CA, Konarska M, McCarty R. Sympathetic-adrenal medullary responses to acute stress in Dahl hypertensive (S/JR) rats. Physiol Behav. 1989 Jan;45(1):27-31. doi: 10.1016/0031-9384(89)90162-5. PMID: 2727139.
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Elsevier Science

Physiol Behav. 1989 Jan;45(1):27-31. doi: 10.1016/0031-9384(89)90162-5.

Sympathetic-adrenal medullary responses to acute stress in Dahl hypertensive (S/JR) rats.

Physiology & behavior

C A Murphy, M Konarska, R McCarty

Affiliations

  1. Department of Psychology, University of Virginia, Charlottesville 22903.

PMID: 2727139 DOI: 10.1016/0031-9384(89)90162-5

Abstract

Sympathetic-adrenal medullary responses to acute footshock stress were assessed in inbred Dahl salt-sensitive (S/JR) and salt-resistant (R/JR) rats by measuring plasma levels of norepinephrine (NE) and epinephrine (EPI). Ten-week-old S/JR and R/JR rats were surgically prepared with indwelling tail artery catheters which permitted direct measurements of mean arterial pressure (MAP, mmHg) and heart rate (HR, beats/min) and remote sampling of blood. Two days after surgery, S/JR and R/JR rats were subjected to an acute stress paradigm. Blood samples were collected before and 3 minutes after transfer of rats to a shock chamber, after 1 minute of intermittent footshock, and again 5 minutes later. S/JR rats had significantly higher resting MAP's compared to R/JR rats. In contrast, baseline heart rates were similar for rats of the two strains. Basal plasma levels of NE and EPI were also similar in S/JR and R/JR rats. Upon transfer from the home cage to a shock chamber, S/JR rats exhibited significant increases in plasma levels of both catecholamines, while R/JR rats maintained circulating levels of NE and EPI that were near baseline values. However, S/JR and R/JR rats had similar increments in plasma NE and EPI following acute footshock stress. Five minutes after footshock, levels of NE and EPI returned toward baseline values for R/JR's, but remained significantly elevated above baseline in hypertensive S/JR rats. These data suggest that S/JR rats are more responsive than R/JR controls to the mild stress of transfer, but exhibit comparable responses to the more intense stress of inescapable footshock.(ABSTRACT TRUNCATED AT 250 WORDS)

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