Display options
Cite
Shi Y, Liu X, Luo Z, et al. The impact of microbubble-enhanced therapeutic ultrasound combined with prothrombin on microwave ablation in the rabbit liver. Med Ultrason. 2016;18(4):438-445doi: 10.11152/mu-869.
Shi, Y., Liu, X., Luo, Z., Gu, F., He, J., Yan, P., Zhang, J., & Zhou, X. (2016). The impact of microbubble-enhanced therapeutic ultrasound combined with prothrombin on microwave ablation in the rabbit liver. Medical ultrasonography, 18(4), 438-445. https://doi.org/10.11152/mu-869
Shi, Ying, et al. "The impact of microbubble-enhanced therapeutic ultrasound combined with prothrombin on microwave ablation in the rabbit liver." Medical ultrasonography vol. 18,4 (2016): 438-445. doi: https://doi.org/10.11152/mu-869
Shi Y, Liu X, Luo Z, Gu F, He J, Yan P, Zhang J, Zhou X. The impact of microbubble-enhanced therapeutic ultrasound combined with prothrombin on microwave ablation in the rabbit liver. Med Ultrason. 2016 Dec 05;18(4):438-445. doi: 10.11152/mu-869. PMID: 27981275.
Copy Download .nbib Format: NLM
Share it on

Med Ultrason. 2016 Dec 05;18(4):438-445. doi: 10.11152/mu-869.

The impact of microbubble-enhanced therapeutic ultrasound combined with prothrombin on microwave ablation in the rabbit liver.

Medical ultrasonography

Ying Shi, Xinyue Liu, Zhenli Luo, Fen Gu, Jianguo He, Ping Yan, Junwang Zhang, Xiaodong Zhou

Affiliations

  1. Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi'an, Department of Ultrasound, the Second Hospital of Shanxi Medical University, Taiyuan, China.
  2. Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  3. Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  4. Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan, China.
  5. Department of Gastroenterology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
  6. Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi'an, China. [email protected].

PMID: 27981275 DOI: 10.11152/mu-869

Abstract

AIM: This study aimed to investigate the effect of microbubble-enhanced ultrasound (MEUS) combined with prothrombin on regional hepatic circulation and microwave ablation (MWA) in rabbit livers.

MATERIALS AND METHODS: High-pressureamplitude therapeutic ultrasound (TUS) was used to treat 52 surgically exposed livers of healthy New Zealand rabbits: 13 livers were treated with MEUS alone, 13 with MEUS and prothrombin (PMEUS), 13 with ultrasound plus normal saline and 13 with ultrasound plus prothrombin as controls. Contrast-enhanced ultrasound (CEUS) imaging was performed on the exposed livers before and after treatment, and acoustic quantification was done to assess liver perfusion. Then, the liver was divided into two parts, one was used for pathologic examination and the other was ablated with microwave (MWA) and then processedfor pathologic examination.

RESULTS: The CEUS images and Peak value after treatment in the PMEUS group were significantly reduced as compared to the remaining 3 groups (p<0.05). Occasional piecemeal hemorrhage was evidenced in the pathological examination in the MEUS group. Obvious cellular degeneration and necrosis with thrombosis were observed in the PMEUS group. Electron microscopy showed endothelial damage in both the MEUS group and PMEUS group. After MWA, coagulated volumes (V) in the PMEUS group were larger than in the remaining 3 groups (p<0.05). The cell ultrastructure disorder wasmore severe in the PMEUS group than in remaining 3 groups.

CONCLUSION: PMEUS promotes endothelial injury and produces more obvious thrombotic occlusion, improving the therapeutic effect of MWA on the rabbit liver.

Substances

MeSH terms

Publication Types