Display options
Cite
Khan S, Trivedi V, Mitchell J, et al. Conversion of sustained release omeprazole loaded buccal films into fast dissolving strips using supercritical carbon dioxide (scCO2) processing, for potential paediatric drug delivery. Eur J Pharm Sci. 2016;93:45-55doi: 10.1016/j.ejps.2016.08.007.
Khan, S., Trivedi, V., Mitchell, J., & Boateng, J. S. (2016). Conversion of sustained release omeprazole loaded buccal films into fast dissolving strips using supercritical carbon dioxide (scCO2) processing, for potential paediatric drug delivery. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 9345-55. https://doi.org/10.1016/j.ejps.2016.08.007
Khan, Sajjad, et al. "Conversion of sustained release omeprazole loaded buccal films into fast dissolving strips using supercritical carbon dioxide (scCO2) processing, for potential paediatric drug delivery." European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences vol. 93 (2016): 45-55. doi: https://doi.org/10.1016/j.ejps.2016.08.007
Khan S, Trivedi V, Mitchell J, Boateng JS. Conversion of sustained release omeprazole loaded buccal films into fast dissolving strips using supercritical carbon dioxide (scCO2) processing, for potential paediatric drug delivery. Eur J Pharm Sci. 2016 Oct 10;93:45-55. doi: 10.1016/j.ejps.2016.08.007. Epub 2016 Aug 04. PMID: 27497613.
Copy Download .nbib Format: NLM
Share it on

Eur J Pharm Sci. 2016 Oct 10;93:45-55. doi: 10.1016/j.ejps.2016.08.007. Epub 2016 Aug 04.

Conversion of sustained release omeprazole loaded buccal films into fast dissolving strips using supercritical carbon dioxide (scCO2) processing, for potential paediatric drug delivery.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Sajjad Khan, Vivek Trivedi, John Mitchell, Joshua S Boateng

Affiliations

  1. Department of Pharmaceutical, Chemical & Environmental Sciences, Faculty of Engineering and Science, University of Greenwich at Medway, Central Avenue, Chatham Maritime, ME4 4TB Kent, UK.
  2. Department of Pharmaceutical, Chemical & Environmental Sciences, Faculty of Engineering and Science, University of Greenwich at Medway, Central Avenue, Chatham Maritime, ME4 4TB Kent, UK. Electronic address: [email protected].
  3. Department of Pharmaceutical, Chemical & Environmental Sciences, Faculty of Engineering and Science, University of Greenwich at Medway, Central Avenue, Chatham Maritime, ME4 4TB Kent, UK. Electronic address: [email protected].

PMID: 27497613 DOI: 10.1016/j.ejps.2016.08.007

Abstract

This study involves the development of thin oral solvent cast films for the potential delivery of the proton pump inhibitor, omeprazole (OME) via the buccal mucosa for paediatric patients. OME containing films were prepared from ethanolic gels (1% w/w) of metolose (MET) with polyethylene glycol (PEG 400) (0.5% w/w) as plasticiser, and L-arginine (l-arg) (0.2% w/w) as a stabilizer and dried in an oven at 40°C. The blank and drug loaded films were divided into two groups, one group was subjected to supercritical carbon dioxide (scCO2) treatment and the other group untreated. The untreated and scCO2 treated films were then characterised using differential scanning calorimetry, thermogravimetric analysis, scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, hydration (swelling), mucoadhesion and in vitro drug dissolution studies. Treatment of the solvent cast films with scCO2 caused significant changes to the functional and physical properties of the MET films. The original drug loaded MET films showed a sustained release of OME (1h), whereas scCO2 treatment of the formulations resulted in fast dissolving films with >90% drug release within 15min.

Copyright © 2016 Elsevier B.V. All rights reserved.

Keywords: Buccal; Ethanol; Fast dissolving film; Gelatine; Hydroxypropylmethylcellulose; L-arginine; Methylcellulose; Metolose; Omeprazole; Paediatric; Polyethylene glycol; Sodium hydroxide; Supercritical carbon dioxide

Substances

MeSH terms

Publication Types