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Lenzen R, Gottesbüren H, Borchard F, et al. Intrahepatische Cholestase und aplastische Anämie nach Prajmalin-Einnahme. [Intrahepatic cholestasis and aplastic anemia following administration of prajmaline]. Klin Wochenschr. 1988;66(6):264-70doi: 10.1007/BF01748169.
Lenzen, R., Gottesbüren, H., Borchard, F., Wienbeck, M., & Strohmeyer, G. (1988). Intrahepatische Cholestase und aplastische Anämie nach Prajmalin-Einnahme. [Intrahepatic cholestasis and aplastic anemia following administration of prajmaline]. Klinische Wochenschrift, 66(6), 264-70. https://doi.org/10.1007/BF01748169
Lenzen, R, et al. "Intrahepatische Cholestase und aplastische Anämie nach Prajmalin-Einnahme." [Intrahepatic cholestasis and aplastic anemia following administration of prajmaline]. Klinische Wochenschrift vol. 66,6 (1988): 264-70. doi: https://doi.org/10.1007/BF01748169
Lenzen R, Gottesbüren H, Borchard F, Wienbeck M, Strohmeyer G. Intrahepatische Cholestase und aplastische Anämie nach Prajmalin-Einnahme. [Intrahepatic cholestasis and aplastic anemia following administration of prajmaline]. Klin Wochenschr. 1988 Mar 15;66(6):264-70. doi: 10.1007/BF01748169. German. PMID: 2452916.
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Klin Wochenschr. 1988 Mar 15;66(6):264-70. doi: 10.1007/BF01748169.

[Intrahepatic cholestasis and aplastic anemia following administration of prajmaline].

Klinische Wochenschrift

[Article in German]
R Lenzen, H Gottesbüren, F Borchard, M Wienbeck, G Strohmeyer

Affiliations

  1. Universität Düsseldorf, Abteilung für Gastroenterologie.

PMID: 2452916 DOI: 10.1007/BF01748169

Abstract

Intrahepatic cholestasis and aplastic anemia after N-propylajmaline. A 43 year old female patient taking oral contraceptives for more than five years received the antiarrhythmic drug N-propylajmaline for treatment of ventricular arrhythmia. After twelve days (total dosage 510 mg N-propyl-ajmaline) acute severe intrahepatic cholestasis and aplastic anemia developed. The erythropoeisis improved after three weeks of treatment with corticosteroids. However, despite treatment with phenobarbital the jaundice receded very slowly. Even after nine years of follow-up cholestatic enzymes are still significantly elevated although serum bilirubin levels are in the normal range. This case report demonstrates that antiarrhythmic drugs may induce nearly irreversible intrahepatic cholestasis and severe hematological disturbances.

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