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Haratake J, Horie A, Ishii N, et al. Unusual clear regenerative nodules of the liver with accumulation of orcein and victoria blue-positive granules. Acta Pathol Jpn. 1988;38(1):83-8doi: 10.1111/j.1440-1827.1988.tb01074.x.
Haratake, J., Horie, A., Ishii, N., Matsuo, N., & Lee, S. D. (1988). Unusual clear regenerative nodules of the liver with accumulation of orcein and victoria blue-positive granules. Acta pathologica japonica, 38(1), 83-8. https://doi.org/10.1111/j.1440-1827.1988.tb01074.x
Haratake, J, et al. "Unusual clear regenerative nodules of the liver with accumulation of orcein and victoria blue-positive granules." Acta pathologica japonica vol. 38,1 (1988): 83-8. doi: https://doi.org/10.1111/j.1440-1827.1988.tb01074.x
Haratake J, Horie A, Ishii N, Matsuo N, Lee SD. Unusual clear regenerative nodules of the liver with accumulation of orcein and victoria blue-positive granules. Acta Pathol Jpn. 1988 Jan;38(1):83-8. doi: 10.1111/j.1440-1827.1988.tb01074.x. PMID: 2452555.
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Acta Pathol Jpn. 1988 Jan;38(1):83-8. doi: 10.1111/j.1440-1827.1988.tb01074.x.

Unusual clear regenerative nodules of the liver with accumulation of orcein and victoria blue-positive granules.

Acta pathologica japonica

J Haratake, A Horie, N Ishii, N Matsuo, S D Lee

Affiliations

  1. Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Japan.

PMID: 2452555 DOI: 10.1111/j.1440-1827.1988.tb01074.x

Abstract

An unusual nodular transformation of the liver was found in a 53-year-old man with meningoencephalitis who died of brain stem herniation. Postmortem examination revealed marked neuronal ischemic changes and bronchopneumonia as well as meningoencephalitis. The liver showed no significant lesions macroscopically. Histologically, there were many small nodules, less than 1 mm in diameter and composed of clear hepatocytes, throughout the liver. The liver cells in these nodules showed mild hyperplastic changes. Many fine granules, stained by orcein and Victoria blue, were found exclusively in the hepatocytes of these nodules. We describe the peculiar histopathology of this case with reference to some related lesions.

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