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Favaloro EJ, Bradstock KF, Grimsley A, et al. Further studies on the heterogeneity of antigens recognised by CD-1 monoclonal antibodies: distribution of epitopes and analysis of serological binding patterns. Immunol Cell Biol. 1987;65:517-27doi: 10.1038/icb.1987.62.
Favaloro, E. J., Bradstock, K. F., Grimsley, A., Henniker, A., & Kamath, S. (1987). Further studies on the heterogeneity of antigens recognised by CD-1 monoclonal antibodies: distribution of epitopes and analysis of serological binding patterns. Immunology and cell biology, 65517-27. https://doi.org/10.1038/icb.1987.62
Favaloro, E J, et al. "Further studies on the heterogeneity of antigens recognised by CD-1 monoclonal antibodies: distribution of epitopes and analysis of serological binding patterns." Immunology and cell biology vol. 65 (1987): 517-27. doi: https://doi.org/10.1038/icb.1987.62
Favaloro EJ, Bradstock KF, Grimsley A, Henniker A, Kamath S. Further studies on the heterogeneity of antigens recognised by CD-1 monoclonal antibodies: distribution of epitopes and analysis of serological binding patterns. Immunol Cell Biol. 1987 Dec;65:517-27. doi: 10.1038/icb.1987.62. PMID: 2452133.
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Immunol Cell Biol. 1987 Dec;65:517-27. doi: 10.1038/icb.1987.62.

Further studies on the heterogeneity of antigens recognised by CD-1 monoclonal antibodies: distribution of epitopes and analysis of serological binding patterns.

Immunology and cell biology

E J Favaloro, K F Bradstock, A Grimsley, A Henniker, S Kamath

Affiliations

  1. Dept of Hematology, Westmead Hospital, Australia

PMID: 2452133 DOI: 10.1038/icb.1987.62

Abstract

The binding patterns of 28 monoclonal antibodies (MAB) recognizing antigens belonging to Cluster of Differentiation One (CD-1) were analyzed in order to investigate heterogeneity within this cluster. Competitive binding assays using radiolabelled MAB provided detailed information on CD-1 antigenic heterogeneity, and demonstrated that at lease six epitopic regions are recognised as CD-1 MAB. Further studies, based on single cell suspension immunofluorescence assays (using thymocytes and subclones on the cell line Molt-4), suggested that the majority of MAB studied could be serologically separated into three groups. In view of the most recent information that CD-1 MAB recognize at least three different early T-cell differentiation molecules, our results indicate that there are three or more distinct epitopes on the 'gp49'(HTA-1/CD-1a) molecule, two on the 'gp45'(HTA-3/CD-1b) molecule and one on 'gp43'(HTA-2/CD-1c).

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