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Radiol Case Rep. 2016 Jan 05;2(1):5-9. doi: 10.2484/rcr.v1i2.24. eCollection 2007.

Granulocyte-Stimulating Factor-Induced Bone Marrow Reconversion Simulating Neuroblastoma Metastases on MRI: Case Report and Literature Review.

Radiology case reports

Jason C Naples, Mihra S Taljanovic, Michael L Graham, Tim B Hunter

PMID: 27303451 PMCID: PMC4891622 DOI: 10.2484/rcr.v1i2.24


Granulocyte colony-stimulating factor (GCSF), often used as an adjunct to chemotherapy, can pose a dilemma in differentiating the associated bone marrow changes from metastatic disease on magnetic resonance imaging. The phenomenon has been previously reported in children undergoing treatment for primary musculoskeletal malignancies [1, 2]. We present a case of GCSF-induced marrow reconversion simulating neuroblastoma metastases on MR imaging. An interesting observation in our case was intense abnormal signal in a pattern of metaphyseal bands, which, to our knowledge, was not previously reported in the English literature to be associated with GCSF-induced marrow reconversion.


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