Display options
Cite
Fong CT, Dracopoli NC, White PS, et al. Loss of heterozygosity for the short arm of chromosome 1 in human neuroblastomas: correlation with N-myc amplification. Proc Natl Acad Sci U S A. 1989;86(10):3753-7doi: 10.1073/pnas.86.10.3753.
Fong, C. T., Dracopoli, N. C., White, P. S., Merrill, P. T., Griffith, R. C., Housman, D. E., & Brodeur, G. M. (1989). Loss of heterozygosity for the short arm of chromosome 1 in human neuroblastomas: correlation with N-myc amplification. Proceedings of the National Academy of Sciences of the United States of America, 86(10), 3753-7. https://doi.org/10.1073/pnas.86.10.3753
Fong, C T, et al. "Loss of heterozygosity for the short arm of chromosome 1 in human neuroblastomas: correlation with N-myc amplification." Proceedings of the National Academy of Sciences of the United States of America vol. 86,10 (1989): 3753-7. doi: https://doi.org/10.1073/pnas.86.10.3753
Fong CT, Dracopoli NC, White PS, Merrill PT, Griffith RC, Housman DE, Brodeur GM. Loss of heterozygosity for the short arm of chromosome 1 in human neuroblastomas: correlation with N-myc amplification. Proc Natl Acad Sci U S A. 1989 May;86(10):3753-7. doi: 10.1073/pnas.86.10.3753. PMID: 2566996; PMCID: PMC287218.
Copy Download .nbib Format: NLM
Share it on
Full text links
HighWire Free PMC Article

Proc Natl Acad Sci U S A. 1989 May;86(10):3753-7. doi: 10.1073/pnas.86.10.3753.

Loss of heterozygosity for the short arm of chromosome 1 in human neuroblastomas: correlation with N-myc amplification.

Proceedings of the National Academy of Sciences of the United States of America

C T Fong, N C Dracopoli, P S White, P T Merrill, R C Griffith, D E Housman, G M Brodeur

Affiliations

  1. Department of Pediatrics, Washington University School of Medicine, Saint Louis, MO 63110.

PMID: 2566996 PMCID: PMC287218 DOI: 10.1073/pnas.86.10.3753
Free PMC Article

Abstract

Partial monosomy of the short arm of chromosome 1 is the most consistent cytogenetic abnormality found in human neuroblastomas, but its overall frequency and significance are unclear. Using a panel of chromosome-1-specific DNA probes that identify restriction fragment length polymorphisms, we demonstrate that 13 of 47 human neuroblastomas (28%) have somatic loss of heterozygosity (LOH) at one or more loci on the distal short arm of chromosome 1. the chromosomal region that shows LOH most consistently is between 1p36.1 and 1p36.3; loss of a gene or genes in this region may be critical for the development or progression of neuroblastomas. The region of LOH in human neuroblastoma may resemble that described for pheochromocytoma, medullary thyroid carcinoma, and melanoma, which are also tumors of neural-crest origin. Although LOH for distal chromosome 1p can occur in early stages of neuroblastoma, the loss usually occurs in tumors of advanced clinical stages. LOH for the short arm of chromosome 1 correlates significantly with N-myc amplification, suggesting that these two genetic events are related. Indeed, these two lesions appear to characterize a genetically distinct subset of particularly aggressive neuroblastomas.

Cited by

References

  1. Nature. 1987 Dec 10-16;330(6148):578-81 - PubMed
  2. Prog Hematol. 1986;14:229-56 - PubMed
  3. Nature. 1988 Jan 21;331(6153):273-7 - PubMed
  4. Proc Natl Acad Sci U S A. 1987 Dec;84(24):9059-63 - PubMed
  5. Nature. 1986 Aug 14-20;322(6080):644-7 - PubMed
  6. Nature. 1986 Oct 16-22;323(6089):643-6 - PubMed
  7. Nucleic Acids Res. 1986 Nov 25;14(22):9223 - PubMed
  8. Nucleic Acids Res. 1986 Dec 9;14(23):9543 - PubMed
  9. Science. 1987 Mar 13;235(4794):1394-9 - PubMed
  10. Science. 1987 Mar 27;235(4796):1616-22 - PubMed
  11. Proc Natl Acad Sci U S A. 1987 Apr;84(8):2372-6 - PubMed
  12. Science. 1987 Apr 17;236(4799):317-9 - PubMed
  13. Nature. 1987 Jun 25-Jul 1;327(6124):721-4 - PubMed
  14. Proc Natl Acad Sci U S A. 1987 Aug;84(15):5419-23 - PubMed
  15. Science. 1987 Jun 26;236(4809):1657-61 - PubMed
  16. Cancer Res. 1987 Aug 15;47(16):4248-53 - PubMed
  17. Nature. 1987 Aug 6-12;328(6130):524-6 - PubMed
  18. Nature. 1987 Aug 13-19;328(6131):616-9 - PubMed
  19. Hum Genet. 1987 Oct;77(2):175-81 - PubMed
  20. Proc Natl Acad Sci U S A. 1984 Jul;81(13):4213-6 - PubMed
  21. Proc Natl Acad Sci U S A. 1984 Aug;81(16):5026-30 - PubMed
  22. Cancer Res. 1984 Nov;44(11):5444-9 - PubMed
  23. Nature. 1985 Jul 25-31;316(6026):330-4 - PubMed
  24. Proc Natl Acad Sci U S A. 1985 Sep;82(18):6216-20 - PubMed
  25. N Engl J Med. 1985 Oct 31;313(18):1111-6 - PubMed
  26. N Engl J Med. 1987 Oct 29;317(18):1109-13 - PubMed
  27. Nature. 1987 Oct 1-7;329(6138):451-4 - PubMed
  28. Nature. 1987 Oct 15-21;329(6140):642-5 - PubMed
  29. Nature. 1987 Oct 15-21;329(6140):645-7 - PubMed
  30. Science. 1987 Oct 9;238(4824):185-8 - PubMed
  31. Science. 1987 Oct 9;238(4824):193-7 - PubMed
  32. Cell. 1987 Oct 23;51(2):319-37 - PubMed
  33. Proc Natl Acad Sci U S A. 1987 Dec;84(24):9275-9 - PubMed
  34. Proc Natl Acad Sci U S A. 1988 Mar;85(5):1571-5 - PubMed
  35. Nature. 1988 Mar 3;332(6159):85-7 - PubMed
  36. Br J Cancer. 1988 Jan;57(1):121-6 - PubMed
  37. Mol Cell Biol. 1988 May;8(5):2082-8 - PubMed
  38. Prog Clin Biol Res. 1988;271:3-15 - PubMed
  39. Am J Hum Genet. 1988 Oct;43(4):462-70 - PubMed
  40. J Clin Oncol. 1988 Dec;6(12):1874-81 - PubMed
  41. Science. 1988 Dec 16;242(4885):1563-6 - PubMed
  42. Genomics. 1988 Aug;3(2):124-8 - PubMed
  43. Cancer Res. 1981 Nov;41(11 Pt 1):4678-86 - PubMed
  44. Cancer Genet Cytogenet. 1982 Oct;7(2):137-52 - PubMed
  45. J Biol Chem. 1983 Jul 10;258(13):8389-94 - PubMed
  46. Anal Biochem. 1983 Jul 1;132(1):6-13 - PubMed
  47. Nature. 1983 Oct 27-Nov 2;305(5937):779-84 - PubMed
  48. Nature. 1984 May 10-16;309(5964):170-2 - PubMed
  49. Nature. 1984 May 10-16;309(5964):172-4 - PubMed
  50. Science. 1984 Jun 8;224(4653):1121-4 - PubMed
  51. Gene. 1984 May;28(2):263-70 - PubMed
  52. Nature. 1985 Nov 7-13;318(6041):69-73 - PubMed
  53. Cytogenet Cell Genet. 1985;40(1-4):360-489 - PubMed
  54. Nature. 1985 Nov 28-Dec 4;318(6044):377-80 - PubMed
  55. Adv Pediatr. 1987;34:1-44 - PubMed

Substances

MeSH terms

Publication Types

Grant support

LinkOut - more resources