ASAIO Trans. 1989 Jul-Sep;35(3):478-80. doi: 10.1097/00002480-198907000-00099.

Long-term in vivo study of gas diffusion in bilaminar compliance chambers.

ASAIO transactions

N Sakakibara, R R Navarro, M Nasu, L K Fujimoto, R J Kiraly, Y Nosé

PMID: 2512969 DOI: 10.1097/00002480-198907000-00099

Abstract

The problem of gas diffusion from compliance chambers in long-term pulsatile blood pump implantation continues. To evaluate and predict gas diffusion at the intrathoracic tissue interface, eight air-filled static bilaminar compliance chambers were implanted in four calves for a mean duration of 191 days. Mean volume loss was 40.3 +/- 6.2 ml (0.2 ml/day) compared with previous results of 1.2 ml/day for pure Hexsyn diaphragms. The residual gas in the chamber was analyzed as nitrogen = 89.6 +/- 0.6%; oxygen = 1.5 +/- 1.1%; and carbon dioxide = 8.8 +/- 0.6%. The resulting gas composition is assumed equivalent to that of the tissue interface and was used in developing a diffusion model. For a complete left ventricular assist system (LVAS), gas diffusion at the arterial blood and tissue interface was simulated. The predicted time to reach a minimum volume of 90 ml (compliance volume equal to full pump stroke volume) was in excess of 1 year.

Substances

• Membranes, Artificial
• Carbon Dioxide
• Nitrogen
• Oxygen

MeSH terms

• Animals
• Carbon Dioxide / blood
• Cattle
• Diffusion
• Heart, Artificial*
• Heart-Assist Devices*
• Male
• Membranes, Artificial*
• Models, Cardiovascular
• Nitrogen / blood
• Oxygen / blood
• Stroke Volume / physiology

Publication Types

• Journal Article
• Research Support, Non-U.S. Gov't
• Research Support, U.S. Gov't, P.H.S.

Grant support

• 28001/PHS HHS/United States
• 30426/PHS HHS/United States
• 48071/PHS HHS/United States

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