Display options
Cite
Szechtman H, Ahmari SE, Beninger RJ, et al. Obsessive-compulsive disorder: Insights from animal models. Neurosci Biobehav Rev. 2016;76:254-279doi: 10.1016/j.neubiorev.2016.04.019.
Szechtman, H., Ahmari, S. E., Beninger, R. J., Eilam, D., Harvey, B. H., Edemann-Callesen, H., & Winter, C. (2017). Obsessive-compulsive disorder: Insights from animal models. Neuroscience and biobehavioral reviews, 76254-279. https://doi.org/10.1016/j.neubiorev.2016.04.019
Szechtman, Henry, et al. "Obsessive-compulsive disorder: Insights from animal models." Neuroscience and biobehavioral reviews vol. 76 (2017): 254-279. doi: https://doi.org/10.1016/j.neubiorev.2016.04.019
Szechtman H, Ahmari SE, Beninger RJ, Eilam D, Harvey BH, Edemann-Callesen H, Winter C. Obsessive-compulsive disorder: Insights from animal models. Neurosci Biobehav Rev. 2017 May;76:254-279. doi: 10.1016/j.neubiorev.2016.04.019. Epub 2016 May 07. PMID: 27168347; PMCID: PMC5833926.
Copy Download .nbib Format: NLM
Share it on

Neurosci Biobehav Rev. 2017 May;76:254-279. doi: 10.1016/j.neubiorev.2016.04.019. Epub 2016 May 07.

Obsessive-compulsive disorder: Insights from animal models.

Neuroscience and biobehavioral reviews

Henry Szechtman, Susanne E Ahmari, Richard J Beninger, David Eilam, Brian H Harvey, Henriette Edemann-Callesen, Christine Winter

Affiliations

  1. Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada. Electronic address: [email protected].
  2. Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: [email protected].
  3. Departments of Psychology and Psychiatry, Queen's University, Kingston, ON, Canada. Electronic address: [email protected].
  4. Department of Zoology, Tel-Aviv University, Ramat-Aviv 69978, Israel. Electronic address: [email protected].
  5. MRC Unit on Anxiety and Stress Disorders, Center of Excellence for Pharmaceutical Sciences, School of Pharmacy, North-West University, Potchefstroom, South Africa. Electronic address: [email protected].
  6. Bereich Experimentelle Psychiatrie, Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany. Electronic address: [email protected].
  7. Bereich Experimentelle Psychiatrie, Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany. Electronic address: [email protected].

PMID: 27168347 PMCID: PMC5833926 DOI: 10.1016/j.neubiorev.2016.04.019

Abstract

Research with animal models of obsessive-compulsive disorder (OCD) shows the following: (1) Optogenetic studies in mice provide evidence for a plausible cause-effect relation between increased activity in cortico-basal ganglia-thalamo-cortical (CBGTC) circuits and OCD by demonstrating the induction of compulsive behavior with the experimental manipulation of the CBGTC circuit. (2) Parallel use of several animal models is a fruitful paradigm to examine the mechanisms of treatment effects of deep brain stimulation in distinct OCD endophenotypes. (3) Features of spontaneous behavior in deer mice constitute a rich platform to investigate the neurobiology of OCD, social ramifications of a compulsive phenotype, and test novel drugs. (4) Studies in animal models for psychiatric disorders comorbid with OCD suggest comorbidity may involve shared neural circuits controlling expression of compulsive behavior. (5) Analysis of compulsive behavior into its constitutive components provides evidence from an animal model for a motivational perspective on OCD. (6) Methods of behavioral analysis in an animal model translate to dissection of compulsive rituals in OCD patients, leading to diagnostic tests.

Copyright © 2016 Elsevier Ltd. All rights reserved.

Keywords: Animal model; Basal ganglia; Deer mouse; Endophenotypes; Nucleus accumbens core; Obsessive-compulsive disorder; Orbitofrontal cortex; Quinpirole; Security motivation system; Striatum

References

  1. Int J Soc Psychiatry. 1988 Summer;34(2):118-22 - PubMed
  2. Psychiatr Clin North Am. 2006 Jun;29(2):371-90 - PubMed
  3. Physiol Behav. 1971 May;6(5):577-88 - PubMed
  4. Am J Psychiatry. 2014 Mar;171(3):340-9 - PubMed
  5. Brain Cogn. 2004 Jun;55(1):220-34 - PubMed
  6. Behav Brain Res. 2012 Jun 1;231(2):234-49 - PubMed
  7. Behav Neurosci. 2001 Dec;115(6):1301-17 - PubMed
  8. Psychopharmacology (Berl). 2008 Apr;197(3):379-90 - PubMed
  9. Biol Psychiatry. 2009 Jan 1;65(1):75-83 - PubMed
  10. Biol Psychol. 2010 Oct;85(2):331-7 - PubMed
  11. Mol Psychiatry. 2009 Jan;14(1):6-9 - PubMed
  12. Psychiatry Res. 1991 Jan;36(1):1-17 - PubMed
  13. Pharmacol Biochem Behav. 2012 Apr;101(2):231-8 - PubMed
  14. Neurosci Biobehav Rev. 2014 Nov;47:393-409 - PubMed
  15. Arch Gen Psychiatry. 2004 Jun;61(6):564-76 - PubMed
  16. Rev Bras Psiquiatr. 2012 Jun;34 Suppl 1:S81-91 - PubMed
  17. Pharmacol Rev. 1999 Sep;51(3):533-91 - PubMed
  18. Pol J Pharmacol. 1999 Jan-Feb;51(1):55-61 - PubMed
  19. Behav Brain Res. 1989 Sep 1;34(3):199-211 - PubMed
  20. Pharmacol Biochem Behav. 1978 Apr;8(4):333-8 - PubMed
  21. Psychoneuroendocrinology. 2001 Feb;26(2):209-23 - PubMed
  22. Neuroimage. 2010 Jan 1;49(1):121-6 - PubMed
  23. Neuropsychopharmacology. 1995 Aug;13(1):33-9 - PubMed
  24. Neurosci Biobehav Rev. 2008;32(3):525-49 - PubMed
  25. Pharmacol Biochem Behav. 2010 Mar;95(1):72-9 - PubMed
  26. Indian J Clin Biochem. 2009 Apr;24(2):194-7 - PubMed
  27. Neuropsychobiology. 2010;61(4):210-4 - PubMed
  28. Science. 2008 Jul 18;321(5887):421-2 - PubMed
  29. PLoS One. 2012;7(1):e30586 - PubMed
  30. Psychopharmacology (Berl). 2012 Jan;219(2):647-59 - PubMed
  31. Biol Psychiatry. 2013 Feb 15;73(4):321-8 - PubMed
  32. Nat Neurosci. 2006 Jan;9(1):119-26 - PubMed
  33. Dev Psychopathol. 2008 Fall;20(4):1251-83 - PubMed
  34. Arch Gen Psychiatry. 1969 Aug;21(2):240-8 - PubMed
  35. J Clin Pharm Ther. 2016 Apr;41(2):214-9 - PubMed
  36. Behav Res Methods Instrum Comput. 2001 Aug;33(3):398-414 - PubMed
  37. Behav Brain Res. 1991 Nov 26;45(2):117-24 - PubMed
  38. Behav Brain Res. 2011 Jan 1;216(1):84-93 - PubMed
  39. J Neurochem. 2003 May;85(3):601-9 - PubMed
  40. Behav Pharmacol. 2013 Feb;24(1):65-73 - PubMed
  41. J Psychiatry Neurosci. 2008 Sep;33(5):405-12 - PubMed
  42. BMC Neurosci. 2007 Mar 26;8:23 - PubMed
  43. Eur Neuropsychopharmacol. 2015 Nov;25(11):1898-905 - PubMed
  44. Crit Rev Neurobiol. 2004;16(1-2):1-23 - PubMed
  45. Annu Rev Physiol. 2016;78:327-50 - PubMed
  46. Eur Neuropsychopharmacol. 2011 Nov;21(11):814-24 - PubMed
  47. Depress Anxiety. 2010 Jun;27(6):507-27 - PubMed
  48. Psychopharmacology (Berl). 2011 Dec;218(4):749-59 - PubMed
  49. Behav Brain Res. 2000 Apr;109(1):9-18 - PubMed
  50. Am J Psychiatry. 2009 Jun;166(6):664-74 - PubMed
  51. Psychopharmacology (Berl). 1996 Sep;127(2):95-101 - PubMed
  52. J Clin Psychopharmacol. 1993 Jun;13(3):210-3 - PubMed
  53. Prog Neuropsychopharmacol Biol Psychiatry. 2006 May;30(3):389-99 - PubMed
  54. Exp Neurol. 2008 Mar;210(1):217-28 - PubMed
  55. Depress Anxiety. 2015 Aug;32(8):550-62 - PubMed
  56. Ann N Y Acad Sci. 1969 May 15;157(2):569-93 - PubMed
  57. Am J Med Genet B Neuropsychiatr Genet. 2009 Jul 5;150B(5):710-20 - PubMed
  58. J Clin Psychiatry. 1992 Apr;53 Suppl:4-10 - PubMed
  59. Psychopharmacology (Berl). 1984;83(1):1-16 - PubMed
  60. Neurotox Res. 2006 Oct;10(2):103-12 - PubMed
  61. Behav Brain Res. 2013 Mar 1;240:52-9 - PubMed
  62. Psychol Rev. 2004 Jan;111(1):111-27 - PubMed
  63. Biol Mood Anxiety Disord. 2011 Nov 07;1(1):9 - PubMed
  64. Neuropharmacology. 1998 Jul;37(7):953-5 - PubMed
  65. Psychopharmacology (Berl). 2013 May;227(2):277-85 - PubMed
  66. Neuropsychol Rev. 2006 Mar;16(1):3-15 - PubMed
  67. Neurosci Biobehav Rev. 2012 Jan;36(1):47-63 - PubMed
  68. Pharmacol Biochem Behav. 1994 Aug;48(4):921-8 - PubMed
  69. Front Behav Neurosci. 2013 Oct 23;7:135 - PubMed
  70. Neurochem Int. 2004 Mar;44(4):281-6 - PubMed
  71. Dev Psychobiol. 1988 Nov;21(7):679-710 - PubMed
  72. Expert Opin Drug Discov. 2016;11(1):27-43 - PubMed
  73. Br J Pharmacol. 2000 May;130(1):33-40 - PubMed
  74. Neuropsychopharmacology. 1988 Sep;1(3):179-86 - PubMed
  75. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8104-9 - PubMed
  76. Soc Neurosci. 2017 Apr;12 (2):135-149 - PubMed
  77. Psychiatry Res. 2010 Jan 30;175(1-2):114-20 - PubMed
  78. Clin Psychol Rev. 2010 Feb;30(1):78-88 - PubMed
  79. Anim Behav. 1999 Sep;58(3):537-543 - PubMed
  80. Brain Behav Immun. 2013 May;30:156-67 - PubMed
  81. Int Clin Psychopharmacol. 1997 Nov;12(6):297-308 - PubMed
  82. J Clin Psychiatry. 1990 Aug;51 Suppl:36-43; discussion 55-8 - PubMed
  83. Behav Brain Res. 2011 May 16;219(1):149-58 - PubMed
  84. Psychiatry Res. 2009 Dec 30;174(3):202-9 - PubMed
  85. Am J Psychiatry. 2005 May;162(5):876-82 - PubMed
  86. Expert Rev Neurother. 2012 Feb;12(2):219-27 - PubMed
  87. Neurobiol Learn Mem. 1996 Jan;65(1):65-72 - PubMed
  88. Hum Brain Mapp. 2014 Jun;35(6):2852-60 - PubMed
  89. Neuropsychopharmacology. 2010 Mar;35(4):1026-39 - PubMed
  90. Cogn Affect Behav Neurosci. 2016 Jun;16(3):551-60 - PubMed
  91. CNS Spectr. 2008 Sep;13(9 Suppl 14):47-53 - PubMed
  92. Psychopharmacology (Berl). 1994 Jun;115(1-2):95-104 - PubMed
  93. J Pharmacol Exp Ther. 1996 Sep;278(3):1138-45 - PubMed
  94. Brain Res. 1989 Jun 26;490(2):255-67 - PubMed
  95. Eur J Neurosci. 2010 Nov;32(9):1552-63 - PubMed
  96. Psychiatry Res. 2009 Nov 30;170(1):15-21 - PubMed
  97. Eur J Neurosci. 2008 Apr;27(8):1902-11 - PubMed
  98. Psychopharmacology (Berl). 2004 Jun;174(1):111-25 - PubMed
  99. Psychopharmacology (Berl). 2013 May;227(1):55-66 - PubMed
  100. Mol Psychiatry. 2001 Jan;6(1):44-9 - PubMed
  101. N Engl J Med. 2008 Nov 13;359(20):2121-34 - PubMed
  102. J Psychiatr Res. 2012 Oct;46(10):1286-92 - PubMed
  103. Physiol Behav. 1999 Apr;66(2):355-63 - PubMed
  104. Pharmacol Biochem Behav. 1990 Aug;36(4):989-91 - PubMed
  105. Pharmacol Biochem Behav. 2009 May;92(3):514-20 - PubMed
  106. Science. 2013 Jun 7;340(6137):1234-9 - PubMed
  107. Int J Neuropsychopharmacol. 2012 Feb;15(1):69-76 - PubMed
  108. J Clin Psychopharmacol. 2012 Dec;32(6):797-803 - PubMed
  109. Br J Pharmacol. 2011 Oct;164(4):1162-94 - PubMed
  110. Behav Brain Res. 2007 Feb 27;177(2):340-6 - PubMed
  111. Biol Psychiatry. 1994 Mar 15;35(6):408-19 - PubMed
  112. Science. 2003 Oct 3;302(5642):63-72 - PubMed
  113. Psychopharmacology (Berl). 2014 May;231(9):2001-8 - PubMed
  114. Science. 1997 Aug 15;277(5328):953-5 - PubMed
  115. Neuropsychiatr Dis Treat. 2005 Sep;1(3):231-43 - PubMed
  116. Br J Psychiatry. 2009 Nov;195(5):393-402 - PubMed
  117. Behav Pharmacol. 2009 Mar;20(2):119-33 - PubMed
  118. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):348-55 - PubMed
  119. Arch Gen Psychiatry. 2009 Nov;66(11):1189-200 - PubMed
  120. Behav Brain Res. 1997 Dec;89(1-2):199-215 - PubMed
  121. J Clin Psychopharmacol. 2010 Feb;30(1):34-9 - PubMed
  122. CNS Spectr. 2005 Mar;10(3):191-202 - PubMed
  123. J Clin Psychiatry. 2004;65 Suppl 14:11-7 - PubMed
  124. Eur Neuropsychopharmacol. 2011 Jun;21(6):471-83 - PubMed
  125. Nature. 2013 Apr 11;496(7444):219-23 - PubMed
  126. Behav Brain Res. 2009 Dec 1;204(1):182-91 - PubMed
  127. Neurosci Biobehav Rev. 2006;30(4):456-71 - PubMed
  128. Brain Res Rev. 2009 Oct;61(2):210-20 - PubMed
  129. Expert Opin Emerg Drugs. 2014 Mar;19(1):67-77 - PubMed
  130. Prog Neuropsychopharmacol Biol Psychiatry. 2006 May;30(3):374-88 - PubMed
  131. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Feb 15;32(2):487-91 - PubMed
  132. Expert Opin Drug Discov. 2013 Dec;8(12):1515-27 - PubMed
  133. J Anxiety Disord. 2009 Dec;23(8):1047-52 - PubMed
  134. Neurosci Biobehav Rev. 2011 Mar;35(4):1034-41 - PubMed
  135. Biol Psychiatry. 2006 Jun 15;59(12):1198-207 - PubMed
  136. Physiol Behav. 2011 Jun 1;103(3-4):404-11 - PubMed
  137. Neuroscience. 2012 Jun 1;211:83-106 - PubMed
  138. CNS Spectr. 2010 Jul;15(7):445-55 - PubMed
  139. J Psychopharmacol. 2016 Sep;30(9):867-74 - PubMed
  140. Psychiatry Res. 2005 Oct 30;140(1):63-72 - PubMed
  141. J Anxiety Disord. 2011 Jun;25(5):680-5 - PubMed
  142. J Clin Psychol. 1988 Sep;44(5):747-52 - PubMed
  143. Semin Clin Neuropsychiatry. 2001 Apr;6(2):82-101 - PubMed
  144. Behav Brain Funct. 2005 Jul 26;1:11 - PubMed
  145. J Child Adolesc Psychopharmacol. 2003;13 Suppl 1:S61-9 - PubMed
  146. Neurobiol Learn Mem. 2004 Nov;82(3):171-7 - PubMed
  147. Behav Pharmacol. 1993;4(4):405-410 - PubMed
  148. Acta Psychiatr Scand. 2009 Oct;120(4):288-98 - PubMed
  149. Schizophr Res. 2011 Jan;125(1):93-8 - PubMed
  150. J Psychiatry Neurosci. 1996 Nov;21(5):343-5 - PubMed
  151. NeuroRx. 2006 Jan;3(1):69-81 - PubMed
  152. Biol Psychiatry. 2014 Apr 15;75(8):595-605 - PubMed
  153. Eur J Neurosci. 2014 Sep;40(6):2971-9 - PubMed
  154. Neurosci Biobehav Rev. 1992 Winter;16(4):525-34 - PubMed
  155. PLoS One. 2012;7(7):e40760 - PubMed
  156. Psychoneuroendocrinology. 2000 Apr;25(3):301-10 - PubMed
  157. Rev Bras Psiquiatr. 2016 Mar;38(1):17-23 - PubMed
  158. Psychopharmacology (Berl). 2008 Oct;200(2):157-65 - PubMed
  159. CNS Spectr. 2014 Feb;19(1):28-49 - PubMed
  160. Psychopharmacology (Berl). 2006 Jul;186(4):487-503 - PubMed
  161. Psychopharmacology (Berl). 2014 Sep;231(18):3707-18 - PubMed
  162. Behav Neurosci. 1998 Dec;112(6):1475-85 - PubMed
  163. Behav Brain Sci. 2008 Apr;31(2):109-30; discussion 130-178 - PubMed
  164. Biol Psychiatry. 1994 Nov 15;36(10):709-10 - PubMed
  165. Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1956-60 - PubMed
  166. Eur J Neurosci. 2009 Jun;29(12):2401-12 - PubMed
  167. Biol Psychiatry. 2010 Apr 1;67(7):e37-8 - PubMed
  168. Rev Bras Psiquiatr. 2007 Sep;29(3):271-8 - PubMed
  169. Arch Gen Psychiatry. 1988 Dec;45(12):1094-9 - PubMed
  170. Science. 1961 Jan 20;133(3447):195-6 - PubMed
  171. Eur Neuropsychopharmacol. 2005 Jan;15(1):69-74 - PubMed
  172. Biol Psychiatry. 2007 Oct 15;62(8):901-9 - PubMed
  173. Exp Neurol. 2009 Jan;215(1):101-9 - PubMed
  174. Science. 2009 May 22;324(5930):1080-4 - PubMed
  175. Behav Brain Res. 2015 Feb 15;279:211-7 - PubMed
  176. Behav Brain Res. 2012 Jun 1;231(2):289-96 - PubMed
  177. Lancet. 2002 Aug 3;360(9330):397-405 - PubMed
  178. Pharmacol Biochem Behav. 1997 Aug;57(4):863-8 - PubMed
  179. Neurosci Biobehav Rev. 2011 Mar;35(4):1019-33 - PubMed
  180. Behav Brain Res. 2013 Nov 1;256:545-53 - PubMed
  181. Psychopathology. 2003 Sep-Oct;36(5):255-62 - PubMed
  182. J Neural Transm (Vienna). 2007;114(12):1603-9 - PubMed
  183. Behav Pharmacol. 1993;4(4):399-403 - PubMed
  184. BMC Neurosci. 2001;2:4 - PubMed
  185. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Aug 3;61:37-43 - PubMed
  186. J Affect Disord. 2012 Dec 20;143(1-3):138-47 - PubMed
  187. Neuropsychopharmacology. 2008 Dec;33(13):3126-34 - PubMed
  188. Pharmacol Ther. 2011 Dec;132(3):314-32 - PubMed
  189. PLoS One. 2013;8(2):e56105 - PubMed
  190. Appetite. 1981 Mar;2(1):51-66 - PubMed
  191. Nature. 2007 Aug 23;448(7156):894-900 - PubMed
  192. Psychopharmacology (Berl). 2016 Jan;233(1):57-70 - PubMed
  193. Neuroscience. 2016 May 3;321:121-137 - PubMed
  194. Biol Psychiatry. 2016 Jan 1;79(1):7-16 - PubMed
  195. Prog Neuropsychopharmacol Biol Psychiatry. 2006 May;30(3):362-73 - PubMed
  196. JAMA Psychiatry. 2013 Jun;70(6):619-29 - PubMed
  197. Psychiatr Clin North Am. 2000 Sep;23(3):509-17 - PubMed
  198. Annu Rev Psychol. 1988;39:43-68 - PubMed
  199. Neurosci Biobehav Rev. 2015 Feb;49:55-70 - PubMed
  200. J Anxiety Disord. 2003;17(2):233-42 - PubMed
  201. Neuropsychopharmacology. 1998 Aug;19(2):105-13 - PubMed
  202. J Psychiatry Neurosci. 2011 Jul;36(4):E5-29 - PubMed
  203. Neuropsychobiology. 2005;52(2):90-110 - PubMed
  204. Behav Neurosci. 1993 Feb;107(1):3-22 - PubMed
  205. JAMA. 2008 Jan 9;299(2):211-3 - PubMed
  206. Psychopharmacology (Berl). 1997 Nov;134(2):193-200 - PubMed
  207. Front Hum Neurosci. 2013 Sep 09;7:556 - PubMed
  208. Biol Psychiatry. 1997 Sep 15;42(6):446-52 - PubMed
  209. Neuropsychiatr Dis Treat. 2015 Aug 04;11:1939-55 - PubMed
  210. Psychol Rev. 1994 Apr;101(2):312-7 - PubMed
  211. Curr Opin Neurobiol. 2011 Dec;21(6):842-8 - PubMed
  212. Biol Psychiatry. 2011 Dec 1;70(11):1039-48 - PubMed
  213. J Neurosci. 2002 Aug 1;22(15):6309-14 - PubMed
  214. Behav Brain Res. 2006 May 15;169(2):303-11 - PubMed
  215. Expert Opin Drug Discov. 2011 Jul;6(7):725-37 - PubMed
  216. Trends Pharmacol Sci. 2013 Mar;34(3):167-77 - PubMed
  217. CNS Spectr. 2001 Mar;6(3):206-9 - PubMed
  218. Exp Brain Res. 2008 Mar;185(3):497-507 - PubMed
  219. J Clin Neurosci. 2014 May;21(5):815-21 - PubMed
  220. Behav Brain Res. 2011 Feb 2;217(1):195-201 - PubMed

MeSH terms

Publication Types

Grant support