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Stein TA, Burns GP, Wise L. Diagnostic value of liver function tests in bile duct obstruction. J Surg Res. 1989;46(3):226-9doi: 10.1016/0022-4804(89)90061-9.
Stein, T. A., Burns, G. P., & Wise, L. (1989). Diagnostic value of liver function tests in bile duct obstruction. The Journal of surgical research, 46(3), 226-9. https://doi.org/10.1016/0022-4804(89)90061-9
Stein, T A, et al. "Diagnostic value of liver function tests in bile duct obstruction." The Journal of surgical research vol. 46,3 (1989): 226-9. doi: https://doi.org/10.1016/0022-4804(89)90061-9
Stein TA, Burns GP, Wise L. Diagnostic value of liver function tests in bile duct obstruction. J Surg Res. 1989 Mar;46(3):226-9. doi: 10.1016/0022-4804(89)90061-9. PMID: 2564054.
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J Surg Res. 1989 Mar;46(3):226-9. doi: 10.1016/0022-4804(89)90061-9.

Diagnostic value of liver function tests in bile duct obstruction.

The Journal of surgical research

T A Stein, G P Burns, L Wise

Affiliations

  1. Department of Surgery, Long Island Jewish Medical Center, New Hyde Park, New York 11042.

PMID: 2564054 DOI: 10.1016/0022-4804(89)90061-9

Abstract

Serological tests may be of value in differentiating acute and chronic bile duct obstruction because the rate of alteration of hepatic cellular integrity and function will affect the rate of cellular product release. In a canine model the common bile duct was obstructed either suddenly (N = 7) or gradually (N = 5). A control group (N = 5) had the common bile duct dissected free from the surrounding tissues. Blood was taken before and 1, 2, 4, 7, 11, 14, 17, 21, and 28 days after initiating obstruction. Serum alkaline phosphatase, bilirubin, aspartate aminotransferase, alanine aminotransferase, ornithine carbamyl transferase, and gamma-glutamyl transferase levels were significantly greater with sudden compared to gradual occlusion, and the values were larger than those in the control. The range of values of alkaline phosphatase, bilirubin, and aspartate aminotransferase did not overlap in the acute and chronic groups at specific times. Serum albumin and total protein were normal in all groups. The magnitude of alkaline phosphatase, aspartate aminotransferase, and bilirubin elevation may help in the differentiation of acute and chronic biliary obstruction.

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