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Hajjar RA, Hill CS, Samaan NA. Adrenal mediation of the effect of excess ACTH on testosterone levels in male: a study of a patient with probable ACTH secreting medullary thyroid carcinoma. Acta Endocrinol (Copenh). 1975;80(2):339-43doi: 10.1530/acta.0.0800339.
Hajjar, R. A., Hill, C. S., & Samaan, N. A. (1975). Adrenal mediation of the effect of excess ACTH on testosterone levels in male: a study of a patient with probable ACTH secreting medullary thyroid carcinoma. Acta endocrinologica, 80(2), 339-43. https://doi.org/10.1530/acta.0.0800339
Hajjar, R A, et al. "Adrenal mediation of the effect of excess ACTH on testosterone levels in male: a study of a patient with probable ACTH secreting medullary thyroid carcinoma." Acta endocrinologica vol. 80,2 (1975): 339-43. doi: https://doi.org/10.1530/acta.0.0800339
Hajjar RA, Hill CS, Samaan NA. Adrenal mediation of the effect of excess ACTH on testosterone levels in male: a study of a patient with probable ACTH secreting medullary thyroid carcinoma. Acta Endocrinol (Copenh). 1975 Oct;80(2):339-43. doi: 10.1530/acta.0.0800339. PMID: 170770.
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Acta Endocrinol (Copenh). 1975 Oct;80(2):339-43. doi: 10.1530/acta.0.0800339.

Adrenal mediation of the effect of excess ACTH on testosterone levels in male: a study of a patient with probable ACTH secreting medullary thyroid carcinoma.

Acta endocrinologica

R A Hajjar, C S Hill, N A Samaan

PMID: 170770 DOI: 10.1530/acta.0.0800339

Abstract

An adult male patient with probable ectopic ACTH production by a medullary carcinoma of the thyroid, was studied before and after bilateral adrenalectomy. Pre-operatively, the patient had low plasma testosterone levels that returned to normal after surgery. The clinical course and study of the patient showed that, 1) chronic excess of ACTH may lower plasma testosterone levels in man, and 2) that this may be mediated through its effect on the adrenals.

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