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Refaat MM, Fahed AC, Hassanieh S, et al. The Muscle-Bound Heart. Card Electrophysiol Clin. 2016;8(1):223-31doi: 10.1016/j.ccep.2015.10.034.
Refaat, M. M., Fahed, A. C., Hassanieh, S., Hotait, M., Arabi, M., Skouri, H., Seidman, J. G., Seidman, C. E., Bitar, F. F., & Nemer, G. (2016). The Muscle-Bound Heart. Cardiac electrophysiology clinics, 8(1), 223-31. https://doi.org/10.1016/j.ccep.2015.10.034
Refaat, Marwan M, et al. "The Muscle-Bound Heart." Cardiac electrophysiology clinics vol. 8,1 (2016): 223-31. doi: https://doi.org/10.1016/j.ccep.2015.10.034
Refaat MM, Fahed AC, Hassanieh S, Hotait M, Arabi M, Skouri H, Seidman JG, Seidman CE, Bitar FF, Nemer G. The Muscle-Bound Heart. Card Electrophysiol Clin. 2016 Mar;8(1):223-31. doi: 10.1016/j.ccep.2015.10.034. PMID: 26920199; PMCID: PMC6599619.
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Card Electrophysiol Clin. 2016 Mar;8(1):223-31. doi: 10.1016/j.ccep.2015.10.034.

The Muscle-Bound Heart.

Cardiac electrophysiology clinics

Marwan M Refaat, Akl C Fahed, Sylvana Hassanieh, Mostafa Hotait, Mariam Arabi, Hadi Skouri, Jonathan G Seidman, Christine E Seidman, Fadi F Bitar, Georges Nemer

Affiliations

  1. Cardiac Electrophysiology, Cardiology, Department of Internal Medicine, American University of Beirut Faculty of Medicine and Medical Center, PO Box 11-0236, Riad El-Solh, Beirut 1107 2020, Lebanon; Department of Biochemistry and Molecular Genetics, American University of Beirut Faculty of Medicine and Medical Center, PO Box 11-0236, Riad El-Solh, Beirut 1107 2020, Lebanon; Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon; Department of Internal Medicine, American University of Beirut, Beirut, Lebanon. Electronic address: [email protected].
  2. Department of Genetics, Harvard Medical School, Boston, MA, USA; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  3. Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon.
  4. Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.
  5. Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
  6. Department of Genetics, Harvard Medical School, Boston, MA, USA.
  7. Department of Genetics, Harvard Medical School, Boston, MA, USA; Division of Cardiology, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA, USA.

PMID: 26920199 PMCID: PMC6599619 DOI: 10.1016/j.ccep.2015.10.034

Abstract

Hypertrophic cardiomyopathy (HCM) is a familial cardiac disease manifested in a wide phenotype and diverse genotype and, thus, presenting unpredictable risks mainly on young adults. Extensive studies are being conducted to categorize patients and link phenotype with genotype for a better management and control of the disease with all its complications. Because the full mechanisms behind HCM are still not revealed, therapeutics are not definitive. Further research is to be conducted for the generation of a complete picture and directed therapy for HCM.

Copyright © 2016 Elsevier Inc. All rights reserved.

Keywords: Genotype; Hypertrophic cardiomyopathy; Left ventricle; Muscle-bound heart; Phenotype

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