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Lu Y, Day FR, Gustafsson S, et al. New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nat Commun. 2016;7:10495doi: 10.1038/ncomms10495.
Lu, Y., Day, F. R., Gustafsson, S., Buchkovich, M. L., Na, J., Bataille, V., Cousminer, D. L., Dastani, Z., Drong, A. W., Esko, T., Evans, D. M., Falchi, M., Feitosa, M. F., Ferreira, T., Hedman, �. �. K., Haring, R., Hysi, P. G., Iles, M. M., Justice, A. E., Kanoni, S., Lagou, V., Li, R., Li, X., Locke, A., Lu, C., Mägi, R., Perry, J. R., Pers, T. H., Qi, Q., Sanna, M., Schmidt, E. M., Scott, W. R., Shungin, D., Teumer, A., Vinkhuyzen, A. A., Walker, R. W., Westra, H. J., Zhang, M., Zhang, W., Zhao, J. H., Zhu, Z., Afzal, U., Ahluwalia, T. S., Bakker, S. J., Bellis, C., Bonnefond, A., Borodulin, K., Buchman, A. S., Cederholm, T., Choh, A. C., Choi, H. J., Curran, J. E., de Groot, L. C., De Jager, P. L., Dhonukshe-Rutten, R. A., Enneman, A. W., Eury, E., Evans, D. S., Forsen, T., Friedrich, N., Fumeron, F., Garcia, M. E., Gärtner, S., Han, B. G., Havulinna, A. S., Hayward, C., Hernandez, D., Hillege, H., Ittermann, T., Kent, J. W., Kolcic, I., Laatikainen, T., Lahti, J., Mateo Leach, I., Lee, C. G., Lee, J. Y., Liu, T., Liu, Y., Lobbens, S., Loh, M., Lyytikäinen, L. P., Medina-Gomez, C., Michaëlsson, K., Nalls, M. A., Nielson, C. M., Oozageer, L., Pascoe, L., Paternoster, L., Polašek, O., Ripatti, S., Sarzynski, M. A., Shin, C. S., Narančić, N. S., Spira, D., Srikanth, P., Steinhagen-Thiessen, E., Sung, Y. J., Swart, K. M., Taittonen, L., Tanaka, T., Tikkanen, E., van der Velde, N., van Schoor, N. M., Verweij, N., Wright, A. F., Yu, L., Zmuda, J. M., Eklund, N., Forrester, T., Grarup, N., Jackson, A. U., Kristiansson, K., Kuulasmaa, T., Kuusisto, J., Lichtner, P., Luan, J., Mahajan, A., Männistö, S., Palmer, C. D., Ried, J. S., Scott, R. A., Stancáková, A., Wagner, P. J., Demirkan, A., Döring, A., Gudnason, V., Kiel, D. P., Kühnel, B., Mangino, M., Mcknight, B., Menni, C., O'Connell, J. R., Oostra, B. A., Shuldiner, A. R., Song, K., Vandenput, L., van Duijn, C. M., Vollenweider, P., White, C. C., Boehnke, M., Boettcher, Y., Cooper, R. S., Forouhi, N. G., Gieger, C., Grallert, H., Hingorani, A., Jørgensen, T., Jousilahti, P., Kivimaki, M., Kumari, M., Laakso, M., Langenberg, C., Linneberg, A., Luke, A., Mckenzie, C. A., Palotie, A., Pedersen, O., Peters, A., Strauch, K., Tayo, B. O., Wareham, N. J., Bennett, D. A., Bertram, L., Blangero, J., Blüher, M., Bouchard, C., Campbell, H., Cho, N. H., Cummings, S. R., Czerwinski, S. A., Demuth, I., Eckardt, R., Eriksson, J. G., Ferrucci, L., Franco, O. H., Froguel, P., Gansevoort, R. T., Hansen, T., Harris, T. B., Hastie, N., Heliövaara, M., Hofman, A., Jordan, J. M., Jula, A., Kähönen, M., Kajantie, E., Knekt, P. B., Koskinen, S., Kovacs, P., Lehtimäki, T., Lind, L., Liu, Y., Orwoll, E. S., Osmond, C., Perola, M., Pérusse, L., Raitakari, O. T., Rankinen, T., Rao, D. C., Rice, T. K., Rivadeneira, F., Rudan, I., Salomaa, V., Sørensen, T. I., Stumvoll, M., Tönjes, A., Towne, B., Tranah, G. J., Tremblay, A., Uitterlinden, A. G., van der Harst, P., Vartiainen, E., Viikari, J. S., Vitart, V., Vohl, M. C., Völzke, H., Walker, M., Wallaschofski, H., Wild, S., Wilson, J. F., Yengo, L., Bishop, D. T., Borecki, I. B., Chambers, J. C., Cupples, L. A., Dehghan, A., Deloukas, P., Fatemifar, G., Fox, C., Furey, T. S., Franke, L., Han, J., Hunter, D. J., Karjalainen, J., Karpe, F., Kaplan, R. C., Kooner, J. S., McCarthy, M. I., Murabito, J. M., Morris, A. P., Bishop, J. A., North, K. E., Ohlsson, C., Ong, K. K., Prokopenko, I., Richards, J. B., Schadt, E. E., Spector, T. D., Widén, E., Willer, C. J., Yang, J., Ingelsson, E., Mohlke, K. L., Hirschhorn, J. N., Pospisilik, J. A., Zillikens, M. C., Lindgren, C., Kilpeläinen, T. O., & Loos, R. J. (2016). New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nature communications, 710495. https://doi.org/10.1038/ncomms10495
Lu, Yingchang, et al. "New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk." Nature communications vol. 7 (2016): 10495. doi: https://doi.org/10.1038/ncomms10495
Lu Y, Day FR, Gustafsson S, Buchkovich ML, Na J, Bataille V, Cousminer DL, Dastani Z, Drong AW, Esko T, Evans DM, Falchi M, Feitosa MF, Ferreira T, Hedman ÅK, Haring R, Hysi PG, Iles MM, Justice AE, Kanoni S, Lagou V, Li R, Li X, Locke A, Lu C, Mägi R, Perry JR, Pers TH, Qi Q, Sanna M, Schmidt EM, Scott WR, Shungin D, Teumer A, Vinkhuyzen AA, Walker RW, Westra HJ, Zhang M, Zhang W, Zhao JH, Zhu Z, Afzal U, Ahluwalia TS, Bakker SJ, Bellis C, Bonnefond A, Borodulin K, Buchman AS, Cederholm T, Choh AC, Choi HJ, Curran JE, de Groot LC, De Jager PL, Dhonukshe-Rutten RA, Enneman AW, Eury E, Evans DS, Forsen T, Friedrich N, Fumeron F, Garcia ME, Gärtner S, Han BG, Havulinna AS, Hayward C, Hernandez D, Hillege H, Ittermann T, Kent JW, Kolcic I, Laatikainen T, Lahti J, Mateo Leach I, Lee CG, Lee JY, Liu T, Liu Y, Lobbens S, Loh M, Lyytikäinen LP, Medina-Gomez C, Michaëlsson K, Nalls MA, Nielson CM, Oozageer L, Pascoe L, Paternoster L, Polašek O, Ripatti S, Sarzynski MA, Shin CS, Narančić NS, Spira D, Srikanth P, Steinhagen-Thiessen E, Sung YJ, Swart KM, Taittonen L, Tanaka T, Tikkanen E, van der Velde N, van Schoor NM, Verweij N, Wright AF, Yu L, Zmuda JM, Eklund N, Forrester T, Grarup N, Jackson AU, Kristiansson K, Kuulasmaa T, Kuusisto J, Lichtner P, Luan J, Mahajan A, Männistö S, Palmer CD, Ried JS, Scott RA, Stancáková A, Wagner PJ, Demirkan A, Döring A, Gudnason V, Kiel DP, Kühnel B, Mangino M, Mcknight B, Menni C, O'Connell JR, Oostra BA, Shuldiner AR, Song K, Vandenput L, van Duijn CM, Vollenweider P, White CC, Boehnke M, Boettcher Y, Cooper RS, Forouhi NG, Gieger C, Grallert H, Hingorani A, Jørgensen T, Jousilahti P, Kivimaki M, Kumari M, Laakso M, Langenberg C, Linneberg A, Luke A, Mckenzie CA, Palotie A, Pedersen O, Peters A, Strauch K, Tayo BO, Wareham NJ, Bennett DA, Bertram L, Blangero J, Blüher M, Bouchard C, Campbell H, Cho NH, Cummings SR, Czerwinski SA, Demuth I, Eckardt R, Eriksson JG, Ferrucci L, Franco OH, Froguel P, Gansevoort RT, Hansen T, Harris TB, Hastie N, Heliövaara M, Hofman A, Jordan JM, Jula A, Kähönen M, Kajantie E, Knekt PB, Koskinen S, Kovacs P, Lehtimäki T, Lind L, Liu Y, Orwoll ES, Osmond C, Perola M, Pérusse L, Raitakari OT, Rankinen T, Rao DC, Rice TK, Rivadeneira F, Rudan I, Salomaa V, Sørensen TI, Stumvoll M, Tönjes A, Towne B, Tranah GJ, Tremblay A, Uitterlinden AG, van der Harst P, Vartiainen E, Viikari JS, Vitart V, Vohl MC, Völzke H, Walker M, Wallaschofski H, Wild S, Wilson JF, Yengo L, Bishop DT, Borecki IB, Chambers JC, Cupples LA, Dehghan A, Deloukas P, Fatemifar G, Fox C, Furey TS, Franke L, Han J, Hunter DJ, Karjalainen J, Karpe F, Kaplan RC, Kooner JS, McCarthy MI, Murabito JM, Morris AP, Bishop JA, North KE, Ohlsson C, Ong KK, Prokopenko I, Richards JB, Schadt EE, Spector TD, Widén E, Willer CJ, Yang J, Ingelsson E, Mohlke KL, Hirschhorn JN, Pospisilik JA, Zillikens MC, Lindgren C, Kilpeläinen TO, Loos RJ. New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nat Commun. 2016 Feb 01;7:10495. doi: 10.1038/ncomms10495. PMID: 26833246; PMCID: PMC4740398.
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Nat Commun. 2016 Feb 01;7:10495. doi: 10.1038/ncomms10495.

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.

Nature communications

Yingchang Lu, Felix R Day, Stefan Gustafsson, Martin L Buchkovich, Jianbo Na, Veronique Bataille, Diana L Cousminer, Zari Dastani, Alexander W Drong, Tõnu Esko, David M Evans, Mario Falchi, Mary F Feitosa, Teresa Ferreira, Åsa K Hedman, Robin Haring, Pirro G Hysi, Mark M Iles, Anne E Justice, Stavroula Kanoni, Vasiliki Lagou, Rui Li, Xin Li, Adam Locke, Chen Lu, Reedik Mägi, John R B Perry, Tune H Pers, Qibin Qi, Marianna Sanna, Ellen M Schmidt, William R Scott, Dmitry Shungin, Alexander Teumer, Anna A E Vinkhuyzen, Ryan W Walker, Harm-Jan Westra, Mingfeng Zhang, Weihua Zhang, Jing Hua Zhao, Zhihong Zhu, Uzma Afzal, Tarunveer Singh Ahluwalia, Stephan J L Bakker, Claire Bellis, Amélie Bonnefond, Katja Borodulin, Aron S Buchman, Tommy Cederholm, Audrey C Choh, Hyung Jin Choi, Joanne E Curran, Lisette C P G M de Groot, Philip L De Jager, Rosalie A M Dhonukshe-Rutten, Anke W Enneman, Elodie Eury, Daniel S Evans, Tom Forsen, Nele Friedrich, Frédéric Fumeron, Melissa E Garcia, Simone Gärtner, Bok-Ghee Han, Aki S Havulinna, Caroline Hayward, Dena Hernandez, Hans Hillege, Till Ittermann, Jack W Kent, Ivana Kolcic, Tiina Laatikainen, Jari Lahti, Irene Mateo Leach, Christine G Lee, Jong-Young Lee, Tian Liu, Youfang Liu, Stéphane Lobbens, Marie Loh, Leo-Pekka Lyytikäinen, Carolina Medina-Gomez, Karl Michaëlsson, Mike A Nalls, Carrie M Nielson, Laticia Oozageer, Laura Pascoe, Lavinia Paternoster, Ozren Polašek, Samuli Ripatti, Mark A Sarzynski, Chan Soo Shin, Nina Smolej Narančić, Dominik Spira, Priya Srikanth, Elisabeth Steinhagen-Thiessen, Yun Ju Sung, Karin M A Swart, Leena Taittonen, Toshiko Tanaka, Emmi Tikkanen, Nathalie van der Velde, Natasja M van Schoor, Niek Verweij, Alan F Wright, Lei Yu, Joseph M Zmuda, Niina Eklund, Terrence Forrester, Niels Grarup, Anne U Jackson, Kati Kristiansson, Teemu Kuulasmaa, Johanna Kuusisto, Peter Lichtner, Jian'an Luan, Anubha Mahajan, Satu Männistö, Cameron D Palmer, Janina S Ried, Robert A Scott, Alena Stancáková, Peter J Wagner, Ayse Demirkan, Angela Döring, Vilmundur Gudnason, Douglas P Kiel, Brigitte Kühnel, Massimo Mangino, Barbara Mcknight, Cristina Menni, Jeffrey R O'Connell, Ben A Oostra, Alan R Shuldiner, Kijoung Song, Liesbeth Vandenput, Cornelia M van Duijn, Peter Vollenweider, Charles C White, Michael Boehnke, Yvonne Boettcher, Richard S Cooper, Nita G Forouhi, Christian Gieger, Harald Grallert, Aroon Hingorani, Torben Jørgensen, Pekka Jousilahti, Mika Kivimaki, Meena Kumari, Markku Laakso, Claudia Langenberg, Allan Linneberg, Amy Luke, Colin A Mckenzie, Aarno Palotie, Oluf Pedersen, Annette Peters, Konstantin Strauch, Bamidele O Tayo, Nicholas J Wareham, David A Bennett, Lars Bertram, John Blangero, Matthias Blüher, Claude Bouchard, Harry Campbell, Nam H Cho, Steven R Cummings, Stefan A Czerwinski, Ilja Demuth, Rahel Eckardt, Johan G Eriksson, Luigi Ferrucci, Oscar H Franco, Philippe Froguel, Ron T Gansevoort, Torben Hansen, Tamara B Harris, Nicholas Hastie, Markku Heliövaara, Albert Hofman, Joanne M Jordan, Antti Jula, Mika Kähönen, Eero Kajantie, Paul B Knekt, Seppo Koskinen, Peter Kovacs, Terho Lehtimäki, Lars Lind, Yongmei Liu, Eric S Orwoll, Clive Osmond, Markus Perola, Louis Pérusse, Olli T Raitakari, Tuomo Rankinen, D C Rao, Treva K Rice, Fernando Rivadeneira, Igor Rudan, Veikko Salomaa, Thorkild I A Sørensen, Michael Stumvoll, Anke Tönjes, Bradford Towne, Gregory J Tranah, Angelo Tremblay, André G Uitterlinden, Pim van der Harst, Erkki Vartiainen, Jorma S Viikari, Veronique Vitart, Marie-Claude Vohl, Henry Völzke, Mark Walker, Henri Wallaschofski, Sarah Wild, James F Wilson, Loïc Yengo, D Timothy Bishop, Ingrid B Borecki, John C Chambers, L Adrienne Cupples, Abbas Dehghan, Panos Deloukas, Ghazaleh Fatemifar, Caroline Fox, Terrence S Furey, Lude Franke, Jiali Han, David J Hunter, Juha Karjalainen, Fredrik Karpe, Robert C Kaplan, Jaspal S Kooner, Mark I McCarthy, Joanne M Murabito, Andrew P Morris, Julia A N Bishop, Kari E North, Claes Ohlsson, Ken K Ong, Inga Prokopenko, J Brent Richards, Eric E Schadt, Tim D Spector, Elisabeth Widén, Cristen J Willer, Jian Yang, Erik Ingelsson, Karen L Mohlke, Joel N Hirschhorn, John Andrew Pospisilik, M Carola Zillikens, Cecilia Lindgren, Tuomas Oskari Kilpeläinen, Ruth J F Loos

Affiliations

  1. The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  2. The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  3. MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
  4. Science for Life Laboratory, Uppsala University, 750 85 Uppsala, Sweden.
  5. Department of Medical Sciences, Molecular Epidemiology, Uppsala University, 751 85 Uppsala, Sweden.
  6. Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
  7. Department of Developmental and Regenerative Biology, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  8. West Herts NHS Trust, Herts HP2 4AD, UK.
  9. Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
  10. Institute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland.
  11. Department Epidemiology, Biostatistics and Human Genetics, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada H3T1E2.
  12. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  13. Estonian Genome Center, Univeristy of Tartu, Tartu, 51010, Estonia.
  14. Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge 2142, USA.
  15. Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
  16. Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
  17. University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Queensland 4102, Australia.
  18. MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS82BN, UKnited.
  19. Department of Genomics of Common Disease, School of Public Health, Imperial College London, London W12 0NN, UK.
  20. Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63108, USA.
  21. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
  22. European University of Applied Sciences, Faculty of Applied Public Health, 18055 Rostock, Germany.
  23. Leeds Institute of Cancer and Pathology, Cancer Research UK Leeds Centre, University of Leeds, Leeds LS9 7TF, UK.
  24. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
  25. William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
  26. Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge CB10 1SA, UK.
  27. Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK.
  28. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
  29. Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
  30. Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.
  31. Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.
  32. Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge 02142, USA.
  33. Department of Epidemiology Research, Statens Serum Institut, 2100 Copenhagen, Denmark.
  34. Department of Epidemiology and Popualtion Health, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
  35. Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
  36. Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.
  37. Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.
  38. Lund University Diabetes Centre, Department of Clinical Science, Genetic and Molecular Epidemiology Unit, Skåne University Hosptial, 205 02 Malmö, Sweden.
  39. Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, 901 87 Umeå, Sweden.
  40. Department of Odontology, Umeå University, 901 85 Umeå, Sweden.
  41. Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
  42. Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany.
  43. Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
  44. Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
  45. Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02446, USA.
  46. Partners Center for Personalized Genetic Medicine, Boston, Massachusetts 02446, USA.
  47. Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
  48. Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health and Medical Sceinces, University of Copenhagen, 2200 Copenhagen, Denmark.
  49. Danish Pediatric Asthma Center, Gentofte Hospital, The Capital Region, 2200 Copenhagen, Denmark.
  50. Steno Diabetes Center A/S, DK-2820 Gentofte, Denmark.
  51. University of Groningen, University Medical Center Groningen, Department of Medicine, 9700 RB Groningen, The Netherlands.
  52. Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78245, USA.
  53. CNRS UMR 8199, F-59019 Lille, France.
  54. European Genomic Institute for Diabetes, 59000 Lille, France.
  55. Université de Lille 2, 59000 Lille, France.
  56. National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
  57. Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois 60612, USA.
  58. Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, 751 85 Uppsala, Sweden.
  59. Lifespan Health Research Center, Wright State University Boonshoft School of Medicine, Dayton, Ohio 45420, USA.
  60. Department of Anatomy, Seoul National University College of Medicine, Seoul 03080, Korea.
  61. South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, Texas 78520.
  62. Department of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands.
  63. Harvard Medical School, Boston, Massachusetts 02115, USA.
  64. Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
  65. Department of Internal Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.
  66. California Pacific Medical Center Research Institute, San Francisco, California 94107, USA.
  67. Department of General Practice and Primary Health Care, University of Helsinki, FI-00014 Helsinki, Finland.
  68. INSERM, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France.
  69. Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France.
  70. Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France.
  71. Univ Paris Diderot, Sorbonne Paris Cité, UMR_S 1138, Centre de Recherche des Cordeliers, F-75006 Paris, France.
  72. Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland 20892, USA.
  73. Department of Medicine A, University Medicine Greifswald, 17475 Greifswald, Germany.
  74. Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do 370914, Korea.
  75. MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
  76. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
  77. University of Groningen, University Medical Center Groningen, Department of Cardiology, 9700 RB Groningen, The Netherlands.
  78. Department of Public Health, Faculty of Medicine, University of Split, Split 21000, Croatia.
  79. Hospital District of North Karelia, FI-80210 Joensuu, Finland.
  80. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, FI-70211 Kuopio, Finland.
  81. Folkhälsan Research Centre, FI-00290 Helsinki, Finland.
  82. Institute of Behavioural Sciences, University of Helsinki, FI-00014 Helsinki, Finland.
  83. Department of Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA.
  84. Research Service, Veterans Affairs Medical Center, Portland, Oregon 97239, USA.
  85. Max Planck Institute for Molecular Genetics, Department of Vertebrate Genomics, 14195 Berlin, Germany.
  86. Max Planck Institute for Human Development, 14194 Berlin, Germany.
  87. Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chaper Hill, North Carolina 27599-7280, USA.
  88. Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos, Level 5, Singapore 138648, Singapore.
  89. Department of Clinical Chemistry, University of Tampere School of Medicine, FI-33014 Tampere, Finland.
  90. Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, FI-33520 Tampere, Finland.
  91. Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam The Netherlands.
  92. Department of Epidemiology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.
  93. Department of Surgical Sciences, Orthopedics, Uppsala University, 751 85 Uppsala, Sweden.
  94. School of Public Health, Oregon Health &Science University, Portland, Oregon 97239, USA.
  95. Bone &Mineral Unit, Oregon Health &Science University, Portland, Oregon 97239, USA.
  96. Institute of Cell &Molecular Biosciences, Newcastle University, Newcastle NE1 7RU, UK.
  97. Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.
  98. Hjelt Institute, University of Helsinki, FI-00014 Helsinki, Finland.
  99. Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Los Angeles 70808, USA.
  100. Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Korea.
  101. Institute for Anthropological Research, Zagreb 10000, Croatia.
  102. The Berlin Aging Study II; Research Group on Geriatrics; Charité-Universitätsmedizin Berlin, 13347 Berlin, Germany.
  103. Lipid Clinic at the Interdisciplinary Metabolism Center, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.
  104. Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA.
  105. EMGO Institute for Health and Care Research, VU University Medical Center, 1081 BT Amsterdam, The Netherlands.
  106. VUMC, Department of Epidemiology and Biostatistics, 1081 BT Amsterdam, The Netherlands.
  107. Department of Pediatrics, University of Oulu, FI-90014 Oulu, Finland.
  108. Department of Pediatrics, Vaasa Central Hospital, FI-65100 Vaasa, Finland.
  109. Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21225, USA.
  110. Department of Epidemiology; University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
  111. Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona JMAAW15, Jamaica.
  112. Faculty of Health Sciences, Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, 70210 Kuopio, Finland.
  113. Department of Medicine, University of Eastern Finland, 70210 Kuopio, Finland.
  114. Kuopio University Hospital, 70029 Kuopio, Finland.
  115. Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
  116. Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
  117. Department of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland.
  118. Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, 3015GE Rotterdam, The Netherlands.
  119. Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
  120. Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
  121. Icelandic Heart Association, Kopavogur 201, Iceland.
  122. University of Iceland, Faculty of Medicine, Reykjavik 101, Iceland.
  123. Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115.
  124. Institute for Aging Research Hebrew Senior Life, Boston, Massachusetts 02131, USA.
  125. Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.
  126. Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA.
  127. Program in Biostatistics and Biomathematics, Divison of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
  128. Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.
  129. Program for Personalized and Genomic Medicine, Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
  130. Geriatric Research and Education Clinical Center, Vetrans Administration Medical Center, Baltimore, Maryland 21042, USA.
  131. Genetics, Projects Clinical Platforms and Sciences, GlaxoSmithKline, Philadelphia, Pennsylvania 19112, USA.
  132. Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.
  133. Center for Medical Systems Biology, 2300 Leiden, The Netherlands.
  134. Department of Internal Medicine, University Hospital Lausanne (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland.
  135. University of Leipzig, IFB Adiposity Diseases, 04103 Leipzig, Germany.
  136. University of Leipzig, Department of Medicine, 04103 Leipzig, Germany.
  137. Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 61053, USA.
  138. German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.
  139. Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK.
  140. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
  141. Faculty of Medicine, University of Aalborg, 9220 Aalborg, Denmark.
  142. Research Centre for Prevention and Health, DK2600 Capital Region of Denmark, Denmark.
  143. Department of Epidemiology and Public Health, UCL, London WC1E 6BT, UK.
  144. Research Centre for Prevention and Health, Glostrup Hospital, 2600 Glostrup, Denmark.
  145. Massachusetts General Hospital, Center for Human Genetic Research, Psychiatric and Neurodevelopmental Genetics Unit, Boston, Massachusetts 02114, USA.
  146. Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, 81377 Munich, Germany.
  147. School of Public Health, Faculty of Medicine, Imperial College London, London W6 8RP, UK.
  148. Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Integrative and Experimental Genomics, University of Lübeck, 23562 Lübeck, Germany.
  149. Ajou University School of Medicine, Department of Preventive Medicine, Suwon Kyoung-gi 443-721, Korea.
  150. Institute of Medical and Human Genetics, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.
  151. Faculty of Health Sciences, University of Southern Denmark, 5000 Odense, Denmark.
  152. Department of Clinical Physiology, Tampere University Hospital, FI-33521 Tampere, Finland.
  153. Department of Clinical Physiology, University of Tampere School of Medicine, FI-33014 Tampere, Finland.
  154. Children's Hospital, Helsinki University Hospital and University of Helsinki, FI-00029 Helsinki, Finland.
  155. Department of Obstetrics and Gynecology, MRC Oulu, Oulu University Hospital and University of Oulu, FI-90029 Oulu, Finland.
  156. Department of Medical Sciences, Uppsala University, 751 85 Uppsala, Sweden.
  157. Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
  158. MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK.
  159. Department of Kinesiology, Laval University, Québec City, Quebec, Canada G1V 0A6.
  160. Institute of Nutrition and Functional Foods, Laval University, Québec City, Quebec, Canada G1V 0A6.
  161. Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FI-20521 Turku, Finland.
  162. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, FI-20520 Turku, Finland.
  163. Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA.
  164. Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, The Capital Region, 2000 Frederiksberg, Denmark.
  165. Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, 3501 DG Utrecht, The Netherlands.
  166. Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
  167. Department of Medicine, University of Turku, FI-20521 Turku, Finland.
  168. School of Nutrition, Laval University, Québec City, Quebec, Canada G1V 0A6.
  169. DZHK (German Centre for Cardiovascular Research), partner site Greifswald, 17475 Greifswald, Germany.
  170. DZD (German Centre for Diabetes Research), partner site Greifswald, 17475 Greifswald, Germany.
  171. Institute of Cellular Medicine, Newcastle University, Newcastle NE2 4HH, UK.
  172. Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK.
  173. Analytical Genetics Group, Regeneron Genetics Center, Regeneron Pharmaceuticals, Inc., Tarrytown, New York 10591, USA.
  174. Imperial College Healthcare NHS Trust, London W12 0HS, UK.
  175. National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.
  176. Department of Epidemiology, Erasmus Medical Center, 3000CA Rotterdam/Zuidholland, The Netherlands.
  177. Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah 21589, Saudi Arabia.
  178. Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
  179. Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin and Bren Simon Cancer Center, Indianapolis, Indiana 46202, USA.
  180. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
  181. Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
  182. Oxford NIHR Biomedical Research Centre, Oxford OX3 7LJ, UK.
  183. National Heart and Lung Institute, Imperial College London, London W12 0NN, UK.
  184. Boston University School of Medicine, Department of Medicine, Section of General Internal Medicine, Boston, Massachusetts 02118, USA.
  185. NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702, USA.
  186. Department of Biostatistics, University of Liverpool, Liverpool L69 3GA, UK.
  187. Carolina Center for Genome Sciences and Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7400, USA.
  188. MRC Unit for Lifelong Health and Ageing at UCL, London WC1B 5JU, UK.
  189. Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.
  190. Department of Medicine, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada H3T1E2.
  191. Department of Twin Research, King's College London, London SE1 1E7, UK.
  192. Division of Endocrinology, Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada H3T1E2.
  193. Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  194. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  195. Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
  196. Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.
  197. Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.
  198. Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics, D-76108 Freiburg, Germany.
  199. The Big Data Institute, University of Oxford, Oxford OX3 7LJ, UK.
  200. The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, 10029, USA.
  201. The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

PMID: 26833246 PMCID: PMC4740398 DOI: 10.1038/ncomms10495

Abstract

To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.

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