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Delost GR, Delost ME, Armile J, et al. Staphylococcus aureus carriage rates and antibiotic resistance patterns in patients with acne vulgaris. J Am Acad Dermatol. 2016;74(4):673-8doi: 10.1016/j.jaad.2015.11.025.
Delost, G. R., Delost, M. E., Armile, J., & Lloyd, J. (2016). Staphylococcus aureus carriage rates and antibiotic resistance patterns in patients with acne vulgaris. Journal of the American Academy of Dermatology, 74(4), 673-8. https://doi.org/10.1016/j.jaad.2015.11.025
Delost, Gregory R, et al. "Staphylococcus aureus carriage rates and antibiotic resistance patterns in patients with acne vulgaris." Journal of the American Academy of Dermatology vol. 74,4 (2016): 673-8. doi: https://doi.org/10.1016/j.jaad.2015.11.025
Delost GR, Delost ME, Armile J, Lloyd J. Staphylococcus aureus carriage rates and antibiotic resistance patterns in patients with acne vulgaris. J Am Acad Dermatol. 2016 Apr;74(4):673-8. doi: 10.1016/j.jaad.2015.11.025. Epub 2016 Jan 14. PMID: 26777099.
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J Am Acad Dermatol. 2016 Apr;74(4):673-8. doi: 10.1016/j.jaad.2015.11.025. Epub 2016 Jan 14.

Staphylococcus aureus carriage rates and antibiotic resistance patterns in patients with acne vulgaris.

Journal of the American Academy of Dermatology

Gregory R Delost, Maria E Delost, James Armile, Jenifer Lloyd

Affiliations

  1. University Hospitals Regional Hospitals, Richmond Heights, Ohio; Lake Erie College of Osteopathic Medicine, Erie, Pennsylvania. Electronic address: [email protected].
  2. Youngstown State University, Youngstown, Ohio.
  3. Lake Erie College of Osteopathic Medicine, Erie, Pennsylvania.
  4. University Hospitals Regional Hospitals, Richmond Heights, Ohio.

PMID: 26777099 DOI: 10.1016/j.jaad.2015.11.025

Abstract

BACKGROUND: Overuse of antibiotics has led to the development of antibiotic-resistant strains of Staphylococcus aureus, which are occurring more frequently within the community.

OBJECTIVE: We sought to determine whether long-term antibiotic therapy for acne alter the carriage rate and antibiotic resistance profiles of S aureus.

METHODS: This was a prospective, cross-sectional, quasiexperimental study. Samples of anterior nares were obtained from dermatology patients given a diagnosis of acne vulgaris (n = 263) who were treated with antibiotics (n = 142) or who were not treated with antibiotics (n = 121). Specimens were tested for the presence of S aureus by growth on mannitol salt agar and then isolated on 5% sheep blood agar. Identification was confirmed based on colonial morphology, Gram stain, catalase, and coagulase testing. Antibiotic susceptibility testing was performed using the VITEK 2 system (bioMerieux, Marcy-l'Étoile, France).

RESULTS: The S aureus carriage rate was significantly lower in patients with acne treated with antibiotics (6.3%) compared with those not treated with antibiotics (15.7%; P = .016). The percentage of S aureus isolates resistant to 1 or more antibiotics did not significantly differ between the 2 groups (P = .434).

LIMITATIONS: Cross-sectional study, patient compliance, and effects of prior acne treatments are limitations.

CONCLUSION: Treatment of patients with acne using antibiotics decreases the S aureus carriage rate but does not significantly alter the antibiotic resistance rates.

Copyright © 2015 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.

Keywords: Propionibacterium acnes; Staphylococcus aureus; acne vulgaris; antibiotic resistance; inducible clindamycin resistance; isotretinoin; methicillin-resistant Staphylococcus aureus; oral antibiotics; topical antibiotics

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