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J Pediatric Infect Dis Soc. 2013 Sep;2(3):248-58. doi: 10.1093/jpids/pit030. Epub 2013 May 19.

Treatment of Latent Tuberculosis Infection in Children.

Journal of the Pediatric Infectious Diseases Society

Andrea T Cruz, Amina Ahmed, Anna M Mandalakas, Jeffrey R Starke

Affiliations

  1. The Tuberculosis Initiative of Texas Children's Hospital, and Sections of Infectious Diseases Emergency Medicine [email protected].
  2. Division of Infectious Diseases, Department of Pediatrics, Carolinas Medical Center, Charlotte, North Carolina.
  3. The Tuberculosis Initiative of Texas Children's Hospital, and Sections of The Tuberculosis Initiative of Texas Children's Hospital, and Sections of.
  4. The Tuberculosis Initiative of Texas Children's Hospital, and Sections of Infectious Diseases.

PMID: 26619479 DOI: 10.1093/jpids/pit030

Abstract

Treatment of latent tuberculosis infection (LTBI) is an effective way of preventing future cases of tuberculosis disease. We review pediatric and adult studies of LTBI treatment (isoniazid and rifampin monotherapy, isoniazid plus rifampin, isoniazid plus rifapentine, and rifampin plus pyrazinamide). Based upon this review and our pediatric experience, we can offer recommendations for routine (isoniazid) and alternative courses of therapy.

© The Author 2013. Published by Oxford University Press on behalf of the Pediatric Infectious Diseases Society. All rights reserved. For Permissions, please e-mail: [email protected].

Keywords: Adherence; Directly Observed Preventive Therapy; Latent Tuberculosis Infection

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